A5101859886- Gastrointestinal Tumor Research and Treatment
- Gastric Cancer Management and Outcomes
- Colorectal Cancer Surgical Treatments
- Gastrointestinal disorders and treatments
- Colorectal and Anal Carcinomas
- Colorectal Cancer Treatments and Studies
- Wound Healing and Treatments
- Electrospun Nanofibers in Biomedical Applications
- Sarcoma Diagnosis and Treatment
- Metastasis and carcinoma case studies
- Diabetic Foot Ulcer Assessment and Management
- Colorectal Cancer Screening and Detection
- Esophageal Cancer Research and Treatment
- Pressure Ulcer Prevention and Management
- Intraperitoneal and Appendiceal Malignancies
- Anorectal Disease Treatments and Outcomes
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Bone Tissue Engineering Materials
- Inflammatory Bowel Disease
- Transplantation: Methods and Outcomes
- Foreign Body Medical Cases
- Antimicrobial agents and applications
- Hydrogels: synthesis, properties, applications
- biodegradable polymer synthesis and properties
- RNA Research and Splicing
Guangdong Academy of Medical Sciences
2016-2025
Guangdong Provincial People's Hospital
2019-2025
Southern Medical University
2023-2025
Shantou University
2016-2025
Shantou University Medical College
2025
Renmin Hospital of Wuhan University
2024-2025
Wuhan University
2024-2025
Sixth Affiliated Hospital of Sun Yat-sen University
2020-2021
Sun Yat-sen University
2020-2021
Guangdong General Hospital
2016-2018
Treatment of wounds in special areas is challenging due to inevitable movements and difficult fixation. Common cotton gauze suffers from incomplete joint surface coverage, confinement movement, lack antibacterial function, frequent replacements. Hydrogels have been considered as good candidates for wound dressing because their flexibility biocompatibility. Nevertheless, the adhesive, mechanical, properties conventional hydrogels are not satisfactory. Herein, cationic polyelectrolyte brushes...
MXenes are very promising emerging materials for diverse applications because of their outstanding properties. However, the effect MXene on cell growth and differentiation had barely been studied. Here, we fabricated titanium carbide (Ti3C2) composite nanofibers as smart biomaterials culture tissue engineering. The were by electrospinning doping displayed excellent hydrophilicity a large number introduced functional hydrophilic groups. nanosurface groups provide good microenvironment...
Due to the complex microenvironment and healing process of diabetic wounds, developing wound dressing with good biocompatibility, mechanical stability, breathability, exudate management, antibacterial ability, immunomodulatory property is highly desired but remains a huge challenge. Herein, multifunctional cryogel designed prepared bio-friendly bacterial cellulose, gelatin, dopamine under condition sodium periodate oxidation. Bacterial cellulose can enhance stability by improving skeleton...
Abstract The integration of hydrogels with bio‐friendly functional components through simple and efficient strategies to construct wound dressings broad‐spectrum antibacterial immunomodulatory properties promote the healing infected diabetic wounds is highly desirable but remains a major challenge. Here, wormwood essential oil (WEO) effectively encapsulated in hydrogel via an O/W‐Pickering emulsion during polymerization methacrylic anhydride gelatin (GelMA), acrylamide (AM), acrylic acid N...
Nonalcoholic fatty liver disease (NAFLD) is the most prevalent chronic without specific FDA-approved drugs. Recent advances suggest that chromatin remodeling and epigenetic alteration contribute to development of NAFLD. The functions corresponding molecular modulator in NAFLD, however, are still elusive. KDM1A, commonly known as LSD1 (lysine-specific histone demethylase 1), has been reported increase glucose uptake hepatocellular carcinoma. In addition, a recent study suggests inhibition...
Yang, Yuesheng M.M.; Zifeng M.D.; Li, Yong , On behalf of the authors Author Information
Colorectal cancer (CRC) is often diagnosed at later stages after it has metastasized to other organs. The development of chemoresistance also contributes a poor prognosis. Therefore, an increased understanding the metastatic properties CRC and could improve patient survival. CUGBP elav-like family member 1 (CELF1) RNA-binding protein, which overexpressed in many human malignant tumors. However, influence CELF1 unclear. V-ets erythroblastosis virus E26 oncogene homologue 2 (ETS2)...
AIMTo evaluate the short-term and long-term outcomes following laparoscopic vs open surgery for pathological T4 (pT4) colorectal cancer.
Rationale: Toothpicks are widely used as a tooth cleaning tool after meals in China. Most of the Chinese toothpicks made wood or bamboo with hard texture and sharp ends. This characteristic has proven to be potentially dangerous when accidentally ingested, they can cause damage perforation digestive tract other subsequent complications. Patient concerns: The main clinical complaints 5 patients this study were mainly acute chronic abdominal pain, duration from 2 days months, 1 case vomiting,...
Synchronous peritoneal metastasis (S-PM) is considered a poor prognostic factor for colorectal cancer (CRC) and there no nomogram to predict the survival of these patients. In this study, we aimed use multicenter data identify factors associated with S-PM CRC construct predicting overall (OS) patients.CRC patients from two medical centers were enrolled between September 2007 June 2017. Multivariate analysis was used independent OS 1-, 2-, 3-year rates in development group. The concordance...
Rectal gastrointestinal stromal tumor (GIST) is a rare digestive disease that has distinct malignant tendency compared to of gastric-derived GIST. At present, there still no standard, and the surgical approach rectal GIST controversial.The clinicopathological data prognosis patients admitted Sixth Affiliated Hospital Sun Yat-sen University from 1998.01.01 2018.12.31 were collected retrospectively. All cases divided into either transanal (TA) group or nontransanal (NTA) group.A total 537...
Pelvic organ prolapse (POP) has become one of the most common serious diseases affecting parous women. Weakening pelvic ligaments plays an essential role in pathophysiology POP. Currently, synthetic materials are widely applied for reconstructive surgery. However, nondegradable meshes POP therapy cannot meet clinical requirements due to its poor biocompatibility. Herein, we fabricated electrospun core–shell nanofibers poly(l-lactic acid)-hyaluronic acid (PLLA/HA). After that, combined them...
BACKGROUND: Variations in survival outcomes are observed the American Joint Committee on Cancer’s 8th edition TNM staging system. OBJECTIVE: Machine learning ensemble methods were used to develop and evaluate effectiveness of a pathological-features-modified tumor node metastasis system predicting for patients with rectal cancer by using commonly reported pathological features, such as histological grade, deposits, perineural invasion, improve prognostic accuracy. DESIGN: This was...
The surgical approach (transthoracic or transabdominal) for patients with Siewert type II adenocarcinoma of the esophagogastric junction (AEG) still remains controversial.Data AEG were collected in Guangdong General Hospital from 2004 to 2014 and we compared their clinicopathological outcome prognosis regard transthoracic (TT) transabdominal (TA) approach.A total 158 analyzed our results demonstrated that overall medium survival was 52 months. Also, 5-year rate 39.1%, which comparable...
Creation of a temporary diverting stoma during rectal cancer surgery is used widely to prevent undesirable outcomes related anastomotic leakage (AL). The transition from (TS) permanent (PS) frequent outcome. Elderly patients may have greater probability PS. We aimed identify risk factors PS and developed nomogram predict the rate for elderly patients.We enrolled (≥70 years) who underwent with TS between January 2014 December 2017 at our hospital. divided into two groups: group group. then...
The transsacrococcygeal (TSC) approach in rectal gastrointestinal stromal tumour (GIST) resection is clinically challenging and controversial, we evaluated its value the present study.We enrolled patients who underwent GIST by TSC during 2008-2018. clinicopathological index, surgical outcome, prognosis were analysed. Prognostic information was obtained from medical records follow-up data. Anal function low anterior syndrome (LARS) score.Among 88 over 10-year study period, 17 median age 55...
Treatment of colorectal cancer (CRC) with synchronous peritoneal metastases (SPM) is controversial, and its prognosis remains poor. Here, we analysed the association between treatment strategies outcomes patients SPM devised a nomogram to improve their prediction. We retrospectively treated at The Sixth Affiliated Hospital, Sun Yat-sen University from June 2007 2018. Kaplan-Meier method log-rank tests was used compare overall survival (OS) among undergoing different therapeutic regimens. Cox...
The biological behavior of primary small gastric gastrointestinal stromal tumor (gGIST) is indolent. cutoff size categorizing gGIST continues to be controversial. To date, there no consensus regarding whether it should 1 cm, 2 or another size. We aimed find a new size.Retrospective clinicopathological and prognosis data patients with from January 1998 2015 were collected among five medical centers in southern China. Tumor was divided into two groups: <1 cm (Mirco group) 1-2 (Small group)....