A5077835349- Natural product bioactivities and synthesis
- Plant-derived Lignans Synthesis and Bioactivity
- Wound Healing and Treatments
- Phytochemistry and Bioactive Compounds
- Diabetic Foot Ulcer Assessment and Management
- Pressure Ulcer Prevention and Management
- Phytochemistry and Biological Activities
- Biological and pharmacological studies of plants
- Plant biochemistry and biosynthesis
- Traditional and Medicinal Uses of Annonaceae
- Berberine and alkaloids research
- Industrial Vision Systems and Defect Detection
- Biochemical effects in animals
- Plant tissue culture and regeneration
- Parallel Computing and Optimization Techniques
- Polymer Foaming and Composites
- Biological Activity of Diterpenoids and Biflavonoids
- Bone Tissue Engineering Materials
- Antioxidant Activity and Oxidative Stress
- Machine Learning in Materials Science
- Advanced Data Storage Technologies
- Bioactive natural compounds
- Nicotinic Acetylcholine Receptors Study
- Oral and Maxillofacial Pathology
- Microbial Metabolic Engineering and Bioproduction
Hunan University
2024-2025
Guangdong Academy of Medical Sciences
2023-2024
Southern Medical University
2023-2024
Guangdong Provincial People's Hospital
2023-2024
Guangdong Pharmaceutical University
2014-2024
Beibu Gulf University
2023-2024
Guangdong Institute of Biological Products and Drugs
2021
State Administration of Traditional Chinese Medicine of the People's Republic of China
2021
Due to the complex microenvironment and healing process of diabetic wounds, developing wound dressing with good biocompatibility, mechanical stability, breathability, exudate management, antibacterial ability, immunomodulatory property is highly desired but remains a huge challenge. Herein, multifunctional cryogel designed prepared bio-friendly bacterial cellulose, gelatin, dopamine under condition sodium periodate oxidation. Bacterial cellulose can enhance stability by improving skeleton...
Abstract The integration of hydrogels with bio‐friendly functional components through simple and efficient strategies to construct wound dressings broad‐spectrum antibacterial immunomodulatory properties promote the healing infected diabetic wounds is highly desirable but remains a major challenge. Here, wormwood essential oil (WEO) effectively encapsulated in hydrogel via an O/W‐Pickering emulsion during polymerization methacrylic anhydride gelatin (GelMA), acrylamide (AM), acrylic acid N...
Abstract Large-scale atomic/molecular massively parallel simulator (LAMMPS) is a prevalent software package employed for molecular dynamics simulations, enabling the study of materials at atomic and scale. Its performance paramount in numerous industrial applications, driving need ongoing enhancements simulation speed efficiency. Previous works heavily rely on hardware accelerators, which lead to limited high costs. To address this, this work optimizes message passing interface (MPI) memory...
A new flavonoid, 8-(3-hydroxymethyl-2-butenyl)-5,7,2′,4′-tetrahydroxyflavanone (1), along with seven known compounds, (2R)-3α,7,4′-Trihydroxy -5-methoxy-8-prenylflavanone (2), (2R)-3β,7,4′- Trihydroxy-5-methoxy-8-prenylflavanone (3), 3,7-dihydroxycoumarin (4), Shandougenines B (5), Specionin (6), Kushenol N (7) and I (8) were isolated from the roots of Sophora flavescens. Among them, Compound 5 was Leguminous plants, compounds 4 6 flavescens for first time. Their structures elucidated by aid...
Inflammation is a key mediator in the progression of atherosclerosis (AS). Benzoinum, resin secreted from bark Styrax tonkinensis, has been widely used as form traditional Chinese medicine clinical settings to enhance cardiovascular function, but active components responsible for those pharmaceutical effects remain unclear. To better clarify these components, new phenylpropane derivative termed stybenpropol A was isolated benzoinum and characterized via comprehensive spectra nalysis. We...
The precise combination of conflicting biological properties through sophisticated structural and functional design to meet all the requirements anastomotic healing is great demand but remains challenging. Here, we develop a smart responsive staple (Ti-OH-MC) by integrating porous titanium with multifunctional polytannic acid/tannic acid coating. This achieves dynamic sequential regulation antibacterial, anti-inflammatory, cell proliferation properties. During inflammatory phase stoma, our...
A new neolignan compound, tonkinensisin (1), and two phenylpropanoid compounds, B (2) C (3), were isolated from the resin of Styrax tonkinensis (Pierre) Craib ex Hartw. The structures these compounds determined by spectroscopic analysis, relative configurations 1 3 J-based configuration analysis (JBCA) method. All assayed for cytotoxic activities against five tumor cell lines (HepG-2, A549, Hela, MCF-7, PC-3) CCK-8 test in vitro.
An integrated technology for the competitive affinity of two targets using three-phase laminar flow chips. A method rapid screening active components with high efficiency and low toxicity from an extract a traditional Chinese medicine.
The roots of Raphanus sativus L . , also called radish, has been used as a traditional anti-migraine drug in China for hundreds years. However, its bioactive substances and pharmacological mechanism were still not very clear. In this study, two new natural products isolated from the by successive chromatographic procedures, such open silica gel, Sephadex LH-20 RP-18 column chromatograph. structures compounds elucidated Cis-(1-methylazetidin-2-yl) methanol cyclo- (4-methyl-Val-4-methyl-Val)...
Liquidambarines A - C (1-3), three new abietane-type diterpenoids, together with five known compounds (4-8) were isolated from the resin of Liquidambar formosana Hance. Their structures elucidated by combination spectroscopic and computational methods. We explored their anti-inflammatory potential analyzing protein expression iNOS COX-2. Compounds 1 3 exhibit significant activities without cytotoxicity. These experimental studies suggest these diterpenoids have to be candidates for...
G-quadruplex DNA has become an important target for tumor therapy and anti-tumor development. Modern pharmacology proved that Macleaya cordata anti-inflammatory, antibacterial, other pharmacological effects. Affinity ultrafiltration method can screen active ingredients from compounds rapidly, but ligands are difficult to dissociate, which is a key step in conventional method. In this paper, the filtrates after were determined by HPLC-MS substitution. The peaks with 20% reduction of MS...
Simultaneous infection and exudate management remain a great challenge in wound treatment. As one of the most promising approaches, current asymmetric dressings are basically prepared through electrospinning with different kinds materials, interfacial interaction remains unexplored. Herein, first single‐substrate‐based dressing well‐entangled interface, large absorptive capacity, effective fluid reflux prevention, excellent antibacterial, antipenetration properties is developed. The composed...