A5019213801- Synthesis of heterocyclic compounds
- Multicomponent Synthesis of Heterocycles
- Synthesis and Biological Evaluation
- Natural product bioactivities and synthesis
- Synthesis and biological activity
- DNA and Nucleic Acid Chemistry
- Chemical Synthesis and Reactions
- Metal complexes synthesis and properties
- Synthesis and Characterization of Heterocyclic Compounds
- Microbial Natural Products and Biosynthesis
- Advanced biosensing and bioanalysis techniques
- Chemical Synthesis and Analysis
- Electrochemical Analysis and Applications
- Traditional and Medicinal Uses of Annonaceae
- Synthesis and Reactivity of Heterocycles
- Gold and Silver Nanoparticles Synthesis and Applications
- Catalytic C–H Functionalization Methods
- Synthesis and Characterization of Pyrroles
- Hydrology and Watershed Management Studies
- Environmental and Agricultural Sciences
- Marine Sponges and Natural Products
- Molecular Sensors and Ion Detection
- Spectroscopy and Quantum Chemical Studies
- Oxidative Organic Chemistry Reactions
- Liquid Crystal Research Advancements
Guangxi Normal University
2024-2025
Yunnan Agricultural University
2010-2025
Yunnan University
2015-2024
Chinese Academy of Sciences
2020-2024
Tianjin Institute of Industrial Biotechnology
2024
Intelligent Synthetic Biology Center
2024
Hubei University
2024
Army Medical University
2024
Chongqing Medical University
2024
Second Affiliated Hospital of Chongqing Medical University
2024
When p-aminothiophenol (PATP) is used as a probe molecule and adsorbs on silver gold nanogaps, significant change of relative SERS intensities can be observed. Our DFT calculations show that surface photocatalytic coupling reactions yield new species p,p′-dimercaptoazobenzene (DMAB) causing the in spectra.
Dams are often regarded as greenhouse gas (GHG) emitters. However, our study indicated that the world's largest dam, Three Gorges Dam (TGD), has caused significant drops in annual average emissions of CO2, CH4 and N2O over 4300 km along Yangtze River, accompanied by remarkable reductions export CO2 (79%), (50%) (9%) to sea. Since commencement its operation 2003, TGD altered carbonate equilibrium reservoir area, enhanced methanogenesis upstream, restrained denitrification via modifying anoxic...
A cascade oxidative annulation reaction of heterocyclic ketene aminals (HKAs) with internal alkynes catalyzed by [Cp*RhCl2]2 and oxidized Cu(OAc)2·H2O was developed to efficiently synthesize highly functionalized benzo[de]chromene derivatives in good excellent yields. The proceeded the sequential cleavage C(sp2)-H/O-H C(sp2)-H/C(sp2)-H bonds. These multicomponent reactions were regioselective. In addition, all products exhibited intense fluorescence emission solid state, they demonstrated...
A concise and efficient one-pot regio- stereoselective synthesis of structurally diverse spirooxindoles was constructed by simply refluxing a mixture different types heterocyclic ketene aminals, isatins ethyl trifluoroacetate using catalytic piperidine. The advantages this method include high efficiency, mild reaction conditions environmentally benign reagents. These are promising candidates for drug discovery; consequently, library rapidly the present protocol.
Abstract Mitochondrial DNA (mtDNA) is known to play a critical role in cellular functions. However, the fluorescent probe enantio-selectively targeting live-cell mtDNA rare. We recently found that well-known ‘light-switch’ [Ru(phen)2dppz]Cl2 can image nuclear live-cells with chlorophenolic counter-anions via forming lipophilic ion-pairing complex. Interestingly, after washing fresh-medium, was re-localize from nucleus mitochondria ABC transporter proteins. Intriguingly, two enantiomers of...
The adsorption mechanism of aromatic amines on noble metal surfaces and the amine−metal interaction effects Raman spectroscopy are studied by density functional theory. We find that donation nitrogen lone-paired electrons plays an important role in interaction. will be enhanced when aniline adsorbs positively charged clusters because electrostatic attraction. It is observed signal NH2 group sensitive to A significant frequency shift abnormal giant enhancement wagging (ωNH2) mode predicted...
New polycatenar liquid crystals containing two 1,3,4-oxadiazole rings interconnected by a bent 1,3-substituted benzene ring as the central linking unit and three alkoxy chains at each terminal have been synthesized investigated polarizing microscopy, DSC, XRD scattering, UV-vis spectroscopy photoluminescence measurements. All compounds form enantiotropic hexagonal columnar phases broader mesophase ranges than corresponding para substituted analogues show strong blue fluorescence emission...
A efficient and concise one-pot procedure has been developed for the synthesis of highly functional morphan derivatives 3 based on diastereoselective double Michael addition reactions various quinone monoketals 1 with a variety heterocyclic ketene aminals (HKAs) 2 in green solvent water at 60 °C. This protocol is especially suitable rapid parallel syntheses N-containing bridged heterocycles possessing pharmacological activities. As result, library was easily synthesized using this reported...
Although cytochrome P450 enzymes are the most versatile biocatalysts in nature, there is insufficient comprehension of molecular mechanism underlying their functional innovation process. Here, by combining ancestral sequence reconstruction, reverse mutation assay, and progressive forward accumulation, we identified 5 founder residues catalytic pocket flavone 6-hydroxylase (F6H) proposed a “3-point fixation” model to elucidate mechanisms P450s nature. According this design principle pocket,...
An I2/cumene hydroperoxide (CHP)‐mediated tandem cyclization of 2‐aminoaryl ketone oximes with isocyanides has been developed. Various 2‐aminoquinazolines were obtained in 49‐96% yields under transition‐metal‐free conditions, and the resulting 4‐phenylquinazolin‐2‐amines show typical fluorescent emission properties. The key to success this strategy involves formation iminyl radical via N‐O bond cleavage hydroxy oxime.
The garment-to-person virtual try-on (VTON) task, which aims to generate fitting images of a person wearing reference garment, has made significant strides. However, obtaining standard garment is often more challenging than using the already worn by person. To improve ease use, we propose MFP-VTON, Mask-Free framework for Person-to-Person VTON. Recognizing scarcity person-to-person data, adapt model and dataset construct specialized this task. Our approach builds upon pretrained diffusion...
Uptake of purine and pyrimidine nucleosides in astrocytes is important for several reasons: (1) uptake contributes to nucleic acid synthesis; (2) synthesize AMP, ADP, ATP from adenosine GTP guanosine; (3) guanosine function as neuromodulators, whose effects are partly terminated by cellular uptake. It has previously been shown that rapidly accumulated active (Hertz Matz, Neurochem Res 14:755-760, 1989), but the ratio between metabolism-driven unknown, characteristics guanosine. The present...
Abstract A simple, straightforward and versatile multicomponent protocol for the synthesis of indanone‐fused spirooxindole derivatives has been developed. The strategy involves one‐pot three‐component reaction heterocyclic ketene aminals, 1 H ‐indene‐1,3(2 )‐dione dicarbonyl compounds isatins or acenaphthenequinone in an ethanol/water medium catalysed by p ‐TSA at reflux. Mild conditions, operational simplicity, wide substrate scope overall excellent yields make this method highly efficient...
Griseusins F (1) and G (2), two 2a-hydro-8a-(2-oxopropyl)-substituted spiro-naphthoquinones with a previously undescribed C23 polyketide skeleton, were isolated from Yunnan tin mine tailings-derived alkalophilic actinomycete, Nocardiopsis sp. YIM DT266. Their complete structure assignments the absolute stereochemistry elucidated by spectroscopic data, X-ray crystal diffraction, calculation of optical rotation, CD analysis. Compounds 1 2 exhibited strong cytotoxicity (IC50 0.37-0.82 μM)...
Over the past few years, ricin has been discussed frequently because of letters sent to high-ranking government officials containing easily extracted protein native castor beans. Ricin B chain, commercially available and not dangerous when separated from A enables development sensors while minimizing hazards working with a bioterror agent that does have known antidote. Recent events increased risk exposure for civilians, there is need rapid, real-time detection ricin. To this end, aptamers...
An efficient and concise one-pot procedure was developed based on a cascade reaction of 3-formylchromones 1 different types 1,1-enediamines (EDAMs) 2 with alcohols or amines 3 by site-selective synthesis 5H-chromeno[4,3-b]pyridines in an environmentally friendly solvent. This protocol is especially suitable for the rapid parallel 5H-chromeno[4,3-b]pyridine compounds. It also has some advantages, such as convenience operation, short times, use green solvent, ease purification washing crude...
The chemical enhancement effects in surface-enhanced Raman scattering of p-aminothiophenol (PATP, it is also called p-mercaptoaniline or p-aminobenzenthiol) adsorbed on coinage metal surfaces with single thiol end trapped into metal-molecule-metal junctions both and amino groups have been studied by density functional theory (DFT). We focus the influence photon-driven charge transfer (PDCT) bonding interaction (ground-state transfer) intensity frequency shift surface spectra PATP. For...
The interaction of adenine with silver surfaces has been investigated using density functional method. Two isomers N9H and N7H were included to model surface species. Considering the complexity in surface-enhanced Raman spectroscopy, neutral positive clusters used mimic substrate. Following bonding principle, we consider adenine-approached different configurations their relation spectra. For Agn (n = 4, 7, 9) complexes, N9H–Agn complexes are more stable than N7H–Agn ones. corresponding...
A concise and eco-friendly route for the synthesis of highly functionalized bicyclic pyridinium derivatives (3) via a one-pot reaction chromone-3-carboxaldehydes (1) N-benzyl nitro ketene aminals (NBNKAs) (2) under reflux in ethanol media has been developed. The targeted compound was efficiently obtained by filtration without further post-treatment. In two step reaction, C—C C═N bonds were constructed, while at same time one C—O bond cleaved. This protocol represents valuable to obtain...