A5043605467- Climate Change and Health Impacts
- Air Quality and Health Impacts
- Global Health Care Issues
- Lipoproteins and Cardiovascular Health
- Cancer-related molecular mechanisms research
- Sperm and Testicular Function
- MicroRNA in disease regulation
- Reproductive Biology and Fertility
- Wound Healing and Treatments
- Bone Metabolism and Diseases
- Energy and Environment Impacts
- Cancer, Hypoxia, and Metabolism
- Air Quality Monitoring and Forecasting
- Ovarian function and disorders
- RNA Research and Splicing
- Thermoregulation and physiological responses
- Circular RNAs in diseases
- RNA modifications and cancer
- Fibroblast Growth Factor Research
- Diabetes, Cardiovascular Risks, and Lipoproteins
- NF-κB Signaling Pathways
- Diabetes Management and Research
- Pressure Ulcer Prevention and Management
- Oral and Maxillofacial Pathology
- Occupational and environmental lung diseases
Sun Yat-sen University
2020-2025
Tongren Hospital
2018-2025
Shanghai Jiao Tong University
2018-2025
South China University of Technology
2023-2024
Guangdong Academy of Medical Sciences
2023-2024
Southern Medical University
2023-2024
Guangdong Provincial People's Hospital
2023-2024
Jiangsu University
2011-2024
Shanghai Sixth People's Hospital
2015-2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2015-2020
Extreme temperature events (ETEs), including heat wave and cold spell, have been linked to myocardial infarction (MI) morbidity; however, their effects on MI mortality are less clear. Although ambient fine particulate matter (PM
Short-term exposure to ambient air pollution has been linked increased risk of stroke mortality, but its adverse effects on mortality from specific types including ischemic and hemorrhagic remain poorly understood.Using the China National Mortality Surveillance System, we conducted a time-stratified case-crossover study among 412,567 deaths in Jiangsu province, during 2015-2019. Residential daily PM2.5 , PM10 SO2 NO2 CO, O3 concentrations were extracted ChinaHighAirPollutants dataset for...
Due to the complex microenvironment and healing process of diabetic wounds, developing wound dressing with good biocompatibility, mechanical stability, breathability, exudate management, antibacterial ability, immunomodulatory property is highly desired but remains a huge challenge. Herein, multifunctional cryogel designed prepared bio-friendly bacterial cellulose, gelatin, dopamine under condition sodium periodate oxidation. Bacterial cellulose can enhance stability by improving skeleton...
BACKGROUND:MicroRNAs (miRNAs) play a crucial role in regulating diverse biological processes, including drug resistance. We investigated the potential roles of miR-29 family methotrexate (MTX) resistance osteosarcoma. MATERIAL AND METHODS:Two MTX-resistant osteosarcoma cell lines, MG-63/MTX and U2OS/MTX, were generated by continuous exposure to stepwise increasing concentrations MTX. miR-29abc, COL3A1, MCL1 mRNA expression levels determined using quantitative real-time PCR (qRT-PCR). Protein...
Abstract Objectives This study aims to reveal the roles and related mechanisms of Lnc RNA B4 GALT 1‐ AS 1 in osteosarcoma ( OS ) cells stemness migration. Materials methods Real‐time quantitative PCR RT ‐ qPCR was used detect expression several s tissues normal adjacent mammospheres cells. Cell viability, transwell migration, tumour spheres formation vivo assays were examine effects on progression. In addition, immunoprecipitation RIP Luciferase reporter performed determine binding site...
The acute effects of exposure to ambient particulate matter with an aerodynamic diameter ≤1 μm (PM1) on cardiovascular disease (CVD) mortality remain unclear. To investigate whether short-term PM1 was associated from total and/or cause-specific CVDs, and estimate the excess mortality. A time-stratified case-crossover study conducted among 1,081,507 CVD deaths in Jiangsu province, China 2015 2020. We assessed daily residential exposures using a validated grid dataset for each subject....
Exposure to non-optimum ambient temperature has been linked increased risk of total cardiovascular disease (CVD) mortality; however, the adverse effects on mortality from specific types CVD remain less understood.To comprehensively investigate association with cause-specific mortality, and estimate compare corresponding burden.We conducted a time-stratified case-crossover study 1000,014 deaths in Jiangsu province, China during 2015-2019 using data National Mortality Surveillance System....
A case-crossover study among 511,767 cardiovascular disease (CVD) deaths in Jiangsu province, China, during 2015–2021 was conducted to assess the association of exposure ambient ozone (O3) and heat wave with CVD mortality explore their possible interactions. Heat defined as extreme high temperature for at least two consecutive days. Grid-level waves were by multiple combinations apparent thresholds durations. Residential O3 exposures assessed using grid data sets (spatial resolution: 1 km ×...
Abstract The integration of hydrogels with bio‐friendly functional components through simple and efficient strategies to construct wound dressings broad‐spectrum antibacterial immunomodulatory properties promote the healing infected diabetic wounds is highly desirable but remains a major challenge. Here, wormwood essential oil (WEO) effectively encapsulated in hydrogel via an O/W‐Pickering emulsion during polymerization methacrylic anhydride gelatin (GelMA), acrylamide (AM), acrylic acid N...
Abstract Mesenchymal stem cells (MSCs) have drawn great attention because of their therapeutic potential. It has been suggested that intra‐venous infused MSCs could migrate the site injury to help repair damaged tissue. However, mechanism for MSC migration is still not clear so far. In this study, we reported hypoxia increased chemotaxis MSCs. At 4 and 6 hours after culturing in hypoxic (1% oxygen) conditions, number migrated was significantly increased. Meanwhile, also expression HIF‐1α...
Abstract Extensive studies have identified potential adverse effects on semen quality of obesity, based body mass index, but the association between fat distribution, a more relevant indicator for and remains less clear. We conducted longitudinal study 4304 sperm donors from Guangdong Provincial Human Sperm Bank (Guangzhou, China) during 2017–2021. A composition analyzer was used to measure total local percentage each participant. Generalized estimating equations were employed assess count,...
In the context of global warming, frequency heat wave and concentration fine particulate matter (PM2.5) have increased, more people are co-exposed to air pollution extreme heat. However, interaction between PM2.5 on cardiovascular disease (CVD) mortality remained largely unknown. We conducted a time-stratified case-crossover study 40,169 CVD deaths in Shenzhen, China 2013 2022. Meteorological data pollutants information were obtained based residential addresses from validated grid datasets....
Percutaneous vertebral augmentation is an effective and commonly surgical treatment for osteoporotic compression fractures, but the problem of bone cement leakage still cannot be prevented. It has been reported that occurs in approximately 20% vertebroplasty procedures, with symptomatic manifestations 1.6% cases. Leakage into spinal canal increases risk cord nerve injury. The objective this study was to introduce a smart assistive device specifically designed facilitate both injection...
Abstract Objectives This work aims to reveal the roles and related mechanisms of RNA binding protein PUM 2 in osteosarcoma progression. Materials methods Transcriptome analysis based on sequencing data, real‐time quantitative PCR ( RT ‐ qPCR ), western blot were used detect expression RBP s mi OS normal adjacent tissues, correlation between them tissues. , blot, cell viability, transwell migration, tumour spheres formation vivo assays examine effects Additionally, immunoprecipitation RIP )...
Secondary brain damage plays an important role in Traumatic injury (TBI) and inhibition of this has benefit for TBI treatment. However, the pathogenesis secondary remains largely unknown. Here, we tried to explore influence microRNAs (miRNAs) on neuron apoptosis inflammatory response after TBI. Firstly, miRNA expression profiles were analyzed cerebral cortex tissues from mice model (controlled cortical impact) using microarray. miR-23a-3p (miR-23a) attracted our attention as its suppressive...
Potential adverse effects of non-optimum temperatures on human semen quality have drawn much concern worldwide; however, the exposure-response relationship remains less understood.To quantitatively assess association between exposure to ambient temperature and in South China, identify potential critical windows.We conducted a longitudinal study investigate 11,050 volunteers who lived Guangdong province, China intended donate sperm provincial bank during 2016-2021. Exposure 0-90 days before...
Background: MicroRNAs are known to regulate carcinogenesis of osteosarcoma. Although, miR-16-5p is exert inhibitory effects on several forms cancers, its the growth and invasion osteosarcoma have not been studied. Methods: We collected human specimens adjacent tissues detect expression by real-time polymerase chain reaction, immunoblotting, immunohistochemistry. The proliferation, migration, MG63 HOS cells following overexpression inhibition were detected with cell counting kit-8, wound...
To study the association between short-term exposure to air pollutants and mortality of Chronic Ischemic Heart Disease (CIHD).Using a case-crossover design, we investigated 148,443 CIHD deaths from 2015 2020 in Jiangsu Province, China. Exposure six ambient pollutants, including PM10, PM2.5, NO2, CO, SO2, O3, was assessed by extracting daily concentrations validated 10 km × pollutant grids at each subject's residential address. A conditional logistic regression approach used explore...