A5016076700- Sperm and Testicular Function
- Reproductive Biology and Fertility
- Reproductive Health and Technologies
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Climate Change and Health Impacts
- Air Quality and Health Impacts
- Epigenetics and DNA Methylation
- Renal and related cancers
- Male Reproductive Health Studies
- Sexual Differentiation and Disorders
- Ovarian function and disorders
- Hormonal and reproductive studies
- Demographic Trends and Gender Preferences
- Urologic and reproductive health conditions
- Prenatal Screening and Diagnostics
- COVID-19 Impact on Reproduction
- Cancer-related molecular mechanisms research
- Urban Green Space and Health
- Urological Disorders and Treatments
- Urinary Bladder and Prostate Research
- Selenium in Biological Systems
- RNA modifications and cancer
- MicroRNA in disease regulation
- Energy and Environment Impacts
- Extracellular vesicles in disease
National Health and Family Planning Commission
2018-2024
Florida Fertility Institute
2022
Guangdong Provincial Family Planning Hospital
2019-2021
Rathenau Instituut
2019
Planned Parenthood
2014
Yunnan Population and Family Planning Research Institute
2013
Shanghai Institute of Planned Parenthood Research
2007-2013
Huazhong University of Science and Technology
2011-2012
Union Hospital
2012
First Affiliated Hospital Zhejiang University
2007
Exposure to fine particulate matter (PM < 2.5 μm in diameter [PM2.5]) may accelerate human sperm quality decline, although research on this association is limited. Our objective was investigate the relationship between exposure chemical constituents of PM2.5 air pollution and decreased further explore exposure-response relationship. We conducted a multicenter population-based cohort study including 78,952 semen samples from 33,234 donors at 6 provincial banks (covering central, northern,...
Abstract Rare coding variants have been proven to be one of the significant factors contributing spermatogenic failure in patients with non-obstructive azoospermia (NOA) and severe oligospermia (SO). To delineate molecular characteristics idiopathic NOA SO, we performed whole-exome sequencing 314 unrelated Chinese Han origin verified our findings by comparing 400 fertile controls. We detected six pathogenic/likely pathogenic four unknown significance, genes known cause NOA/SO, 9 which had...
Global fertility rates continue to decline and sperm quality is a prime factor affecting male fertility. Both extreme cold heat have been demonstrated be associated with decreased quality, but no epidemiological studies considered human adaptation long-term temperature. Our aim was conduct multi-center retrospective cohort study investigate exposure-response relationship between temperature anomaly (TA) that deviate from climate patterns quality.
Abstract STUDY QUESTION Whether the testis-specific extracellular vesicle (EV) long noncoding RNAs (lncRNAs) in seminal plasma could be utilized to predict presence of testicular spermatozoa nonobstructive azoospermia (NOA) patients? SUMMARY ANSWER Our findings indicate that panel based on EV lncRNAs was a sensitive and specific method predicting may improve clinical decision-making NOA. WHAT IS KNOWN ALREADY The adoption sperm retrieval techniques, especially microdissection extraction...
Abstract Spermatogenesis is precisely controlled by sophisticated gene expression programs and driven epigenetic reprogramming, including histone modification alterations histone-to-protamine transition. Nuclear receptor binding SET domain protein 2 (Nsd2) the predominant methyltransferase catalyzing H3K36me2 its role in male germ cell development remains elusive. Here, we report that NSD2 abundant spermatogenic cells. Conditional loss of Nsd2 postnatal cells impaired fertility owing to...
Potential adverse effects of non-optimum temperatures on human semen quality have drawn much concern worldwide; however, the exposure-response relationship remains less understood.To quantitatively assess association between exposure to ambient temperature and in South China, identify potential critical windows.We conducted a longitudinal study investigate 11,050 volunteers who lived Guangdong province, China intended donate sperm provincial bank during 2016-2021. Exposure 0-90 days before...
Abstract Extensive studies have identified potential adverse effects on semen quality of obesity, based body mass index, but the association between fat distribution, a more relevant indicator for and remains less clear. We conducted longitudinal study 4304 sperm donors from Guangdong Provincial Human Sperm Bank (Guangzhou, China) during 2017–2021. A composition analyzer was used to measure total local percentage each participant. Generalized estimating equations were employed assess count,...
Background It has long been proposed that early embryos and reproductive organs exhibit similar gene expression profiles. However, whether this similarity is propagated to the protein level remains largely unknown. We have previously characterised promiscuous pattern of cell surface proteins on mouse embryonic stem (mES) cells. As also play critical functions in human (hES) cells germ cells, it important reveal a exists for these Methods Principal Findings Surface hES mature sperms (hSperms)...
Summary In this study, we assessed the effect of seasonal variation on semen quality in C hinese by using average highest temperature ( AHT ) ejaculation day for partitioning season periods. A total 13 635 samples were collected and analysed according to day. Semen volume, sperm concentration percentage spermatozoa with normal morphology midsummer > 30 °C) significantly lower than those other periods year. Sperm motility 10–20 °C winter spring was higher that seasons. The head defects...
Sperm donation in China is different from that other countries due to cultural, social and political factors.This research presents the current status of sperm Mainland highlights some problems.Between January 2003 December 2009, 19 471 donors were screened totally 6467 (33.2%) recruited.The primary reasons for non-recruitment either inadequate semen parameters (55.0%) or positive results sexually transmitted diseases (7.9%).There 327 (1.7%) qualified who withdrew program because frustration...
Multiple morphological abnormalities of the sperm flagella (MMAF) is a severe type teratozoospermia. In this study, whole-exome sequencing was conducted on 55 patients with MMAF, and biallelic mutations CFAP58 were identified in two patients. The variants are rare pathogenic, absent CFAP58-mutated sperm. F037/II:1 couple benefited from intracytoplasmic injection (ICSI). This study further indicated that pathogenic gene associated MMAF ICSI an effective treatment.
Abstract Asthenoteratospermia is an important cause of male infertility. Here, we report two infertile patients with severe asthenoteratospermia accompanied by new genetic abnormality. Whole-exome sequencing and bioinformatics analysis suggested that compound heterozygous mutations in DNAH8 (MIM:603337) may be responsible for multiple morphological abnormalities the sperm flagella (MMAF). Immunofluorescence assay showed protein expression was significantly decreased tail patients, electron...
Because of focal spermatogenesis in some nonobstructive azoospermia (NOA) patients, testicular spermatozoa can be retrieved by microdissection sperm extraction (micro-TESE) for intracytoplasmic injection (ICSI) to achieve successful fertilization. Currently, biopsy is widely performed the prognosis micro-TESE; however, it might miss foci with active because 'blind manner' puncture, highlighting needs biomarkers that could indicate actual conditions testis. Thus, we screened microRNAs seminal...