A5101557016- Sperm and Testicular Function
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Reproductive Biology and Fertility
- Male Reproductive Health Studies
- Sexual Differentiation and Disorders
- Testicular diseases and treatments
- Herpesvirus Infections and Treatments
- Metabolism and Genetic Disorders
- Bladder and Urothelial Cancer Treatments
- Hormonal and reproductive studies
- Neonatal Respiratory Health Research
- Reproductive tract infections research
- Single-cell and spatial transcriptomics
- Gastrointestinal disorders and treatments
- Ferroptosis and cancer prognosis
- Selenium in Biological Systems
- Cervical Cancer and HPV Research
- Renal and Vascular Pathologies
- Vascular Malformations and Hemangiomas
- Optimism, Hope, and Well-being
- Urologic and reproductive health conditions
- Congenital Diaphragmatic Hernia Studies
- Metastasis and carcinoma case studies
- Gastric Cancer Management and Outcomes
- TGF-β signaling in diseases
Dalian Medical University
2025
Chongqing Medical University
2025
Second Affiliated Hospital of Chongqing Medical University
2025
Suzhou Traditional Chinese Medicine Hospital
2023-2024
Nanjing University of Chinese Medicine
2022-2023
Guangdong Provincial People's Hospital
2022
Guangdong Provincial Family Planning Hospital
2010-2021
Affiliated Hospital of Jining Medical University
2021
National Health and Family Planning Commission
2017-2018
Kunming Institute of Zoology
2014
From the perspective of philology, this study is first to explore author information,manuscript content,and literary value unpublished and unique manuscript He Yao Zong Bu. Firstly, by examining physician's birth year, residence, social interactions handwriting style, it can be determined that manuscript's Yang Shoushan, a renowned doctor Shicai School Wumen Medical during Qing Dynasty. Bu one two traceable manuscripts currently known have been handed down Yang. Secondly,the main content...
To investigate the effects and mechanisms of MFGE8 on LPS-induced endothelial-to-mesenchymal transition (EndoMT) pulmonary fibrosis in human lung microvascular endothelial cells (HLMECs) a mouse model acute injury. Serum levels were compared between ARDS patients controls. In vitro, HLMECs treated with LPS, siRNA targeting MFGE8, recombinant (rhMFGE8).HLMEC morphology, invasion, migration, EndoMT markers (CD31, ɑ-SMA) evaluated. BMP/Smad1/5-Smad4 signaling Snail expression assessed via...
Because of focal spermatogenesis in some nonobstructive azoospermia (NOA) patients, testicular spermatozoa can be retrieved by microdissection sperm extraction (micro-TESE) for intracytoplasmic injection (ICSI) to achieve successful fertilization. Currently, biopsy is widely performed the prognosis micro-TESE; however, it might miss foci with active because 'blind manner' puncture, highlighting needs biomarkers that could indicate actual conditions testis. Thus, we screened microRNAs seminal...
ABSTRACT The pathophysiology of acute respiratory distress syndrome (ARDS) involves cytokine storms, alveolar-capillary barrier destruction, and fibrotic progression. Pulmonary interstitial fibrosis is an important factor affecting the prognosis ARDS patients. Endothelial-to-mesenchymal transition (EndMT) plays role in development diseases, occurrence EndMT has been observed experimental models LPS-induced lung injury (ALI). Apelin endogenous active polypeptide that maintaining endothelial...
Abstract Background Morphological and functional alterations in aging reproductive organs result decreased male fertility. The epididymis functions as the transition region for post-testicular sperm maturation. And we have previously demonstrated that epididymal initial segment (IS), a of tract essential maturation capacitation, undergoes considerable histological changes chronic immune activation mice during aging. However, local aging-associated cellular molecular aged IS are poorly...
Objective To elucidate the mechanism underlying how Ureaplasma urealyticum (UU) affects sperm quality and identify a therapeutic target. Methods In this prospective observational study, differences in relationships among semen volume, pH, viscosity, liquefaction time, concentration, motility [progressive (PR)], seminal polymorphonuclear (PMN) elastase were analyzed 198 normal samples (control group) UU-infected (observation group). The treated above parameters compared between two groups....
Objective. To explore the risk of Ureaplasma urealyticum (UU) affecting sperm quality. Methods. Prospective cross-sectional study was conducted. In total, 340 semen samples were collected. According to whether they infected with UU, divided into UU-positive group (observation group) and UU-negative (control group). The patients followed up obtain treatment collected again after treatment. characteristics parameters detected compared, relationship UU quality analyzed by mathematical models....
Background Klinefelter’s syndrome (KS) was once considered infertile due to congenital chromosomal abnormalities, but the presence of focal spermatozoa changed this. The key predict and promote spermatogenesis is find targets that regulate spermatogenesis. Objective To explore trend fertility changes in KS patients at different ages identify potential therapeutic targets. Methods Bibliometric analysis used collect clinical research data on from Web Science Core Collection (WoSCC) 1992 2022....
The risk factors for No. 12p and 12b lymph node (LN) metastases in advanced gastric cancer (GC) remain controversial. aim of this study was to investigate the LN GC.From January 1999 December 2005, a retrospective analysis 163 patients with GC who underwent D2 lymphadenectomy addition dissections conducted. Potential clinicopathological that could influence were statistically analyzed.There 15 cases (9.2%) 5 (3.1%) synchronous metastases. A logistic regression revealed Borrmann type (III/IV...
Abstract The influence of varicocele and microsurgical varicocelectomy on semen quality remains unclear. Few studies have investigated the relationship between metabolism abnormalities in reproductive function caused by varicocele, however, there is no study changes after varicocelectomy. Here, we used non-targeted targeted metabolic analysis to investigate different metabolites seminal plasma within normal, groups. We clearly showed that significantly affects metabolism, can reverse this...
Objective Reproductive hormones are a traditional good method to evaluate spermatogenesis but might not accurately represent local spermatogenesis. To find more accurate method, seminal reproductive were studied. Methods A bidirectional cohort study was performed. total of 126 infertile men from 2018 2019 retrospectively analyzed. They divided into nonobstructive azoospermia (NOA), oligozoospermia (OLZ) and normal (NOR) groups. prospective conducted on patients in the NOA OLZ groups for 2...
Endosymbionts influence many aspects of their hosts' health conditions, including physiology, development, immunity, metabolism, etc. Tree shrews (Tupaia belangeri chinensis) have attracted increasing attention in modeling human diseases and therapeutic responses due to close relationship with primates. To clarify the situation symbiotic bacteria from body surface, oral cavity, anus, 12 wild third generation captive tree were examined. Based on morphological cultural characteristics,...
Abstract Background The prevalence and mortality of bladder cancer (BLCA) present a significant medical challenge. While the function senescence-related genes in tumor development is recognized, their prognostic significance BLCA has not been thoroughly explored. Methods transcriptome datasets were sourced from TCGA GEO repositories. Gene groupings determined through differential gene expression non-negative matrix factorization (NMF) methodologies. Key senescence-linked isolated using...
Objective: The aim of the study was to explore evidence JWRJD in treatment cryptozoospermia. Methods: A total 162 cryptozoospermia patients with varicocele who refused undergo surgery were included from January 2021 December 2021. They divided into Jiawei Runjing Decoction group (group A), tamoxifen B), and no C), after follow-up for 3 months, therapeutic effectiveness compared. Network pharmacology used analyze validate effects mechanisms JWRJD. Results: Fifty-eight treated JWRJD, 55...
Microsurgery of andrology always brings unexpected findings. Scrotal calculi are rare and unique, which easily confused with tumor. To understand its etiology harm, our study retrospectively analyzed the clinical characteristics men scrotal to provide a reference for practice.The data patients who underwent microscopic testicular sperm extraction (MTESE) epididymal aspiration (MESA) from January 1, 2018 December 31, 2021 were analyzed. Data screening was performed on cases in found or not,...