A5044853072- Cancer-related gene regulation
- Immune cells in cancer
- Wnt/β-catenin signaling in development and cancer
- Glioma Diagnosis and Treatment
- Renal and related cancers
- Cancer Immunotherapy and Biomarkers
- Ferroptosis and cancer prognosis
- Sperm and Testicular Function
- Alzheimer's disease research and treatments
- Cancer-related molecular mechanisms research
- Neuroinflammation and Neurodegeneration Mechanisms
- Epigenetics and DNA Methylation
- Histone Deacetylase Inhibitors Research
- Caveolin-1 and cellular processes
- Helicobacter pylori-related gastroenterology studies
- Gastric Cancer Management and Outcomes
- Acute Myeloid Leukemia Research
- Bladder and Urothelial Cancer Treatments
- Reproductive System and Pregnancy
- Reproductive Biology and Fertility
- Single-cell and spatial transcriptomics
- Advanced biosensing and bioanalysis techniques
- Cancer Mechanisms and Therapy
- Computational Drug Discovery Methods
- Protein Structure and Dynamics
Jilin Electric Power Research Institute (China)
2024-2025
Cornell University
2016-2024
Lander Institute
2018-2024
Weill Cornell Medicine
2018-2024
Rancho BioSciences (United States)
2024
People's Liberation Army 401 Hospital
2022
Chinese People's Liberation Army
2022
University of Calgary
2020-2021
Second Xiangya Hospital of Central South University
2020-2021
Central South University
2020-2021
Recent studies have shown the importance of dynamic tumor microenvironment (TME) in high-grade gliomas (HGGs). In particular, myeloid cells are known to mediate immunosuppression glioma; however, it is still unclear if play a role low-grade glioma (LGG) malignant progression. Here, we investigate cellular heterogeneity TME using single-cell RNA sequencing murine model that recapitulates progression LGG HGG. LGGs show increased infiltrating CD4
Aging manifests with architectural alteration and functional decline of multiple organs throughout an organism. In mammals, aged skin is accompanied by a marked reduction in hair cycling appearance bald patches, leading researchers to propose that follicle stem cells (HFSCs) are either lost, differentiate, or change epidermal fate during aging. Here, we employed single-cell RNA-sequencing interrogate aging-related changes the HFSCs. Surprisingly, although numbers declined, aging HFSCs were...
Abstract Glioblastoma (GBM), an incurable tumor, remains difficult to model and more importantly treat due its genetic/epigenetic heterogeneity plasticity across cellular states. The ability of current tumor models recapitulate the states found in primary tumors unexplored. To address this issue, we compared single-cell RNA sequencing cells from 5 patients four patient-specific glioblastoma stem cell (GSC)–derived types, including glioma spheres, organoids, cerebral organoids (GLICO),...
Spermatogenesis is the process by which male gametes are formed from a self-renewing population of spermatogonial stem cells (SSCs) residing in testis. SSCs represent less than 1% total testicular cell adults, but must achieve stable balance between self-renewal and differentiation. Once differentiation has occurred, newly highly proliferative spermatogonia then enter meiotic program DNA content doubled, halved twice to create haploid gametes. While much known about critical cellular...
Abstract Hormone receptor (HR) + breast cancer (BC) causes most BC-related deaths, calling for improved therapeutic approaches. Despite expectations, immune checkpoint blockers (ICBs) are poorly active in patients with HR BC, part reflecting the lack of preclinical models that recapitulate disease progression immunocompetent hosts. We demonstrate mammary tumors driven by medroxyprogesterone acetate (M) and 7,12-dimethylbenz[a]anthracene (D) several key features human luminal B HER2 −...
Triggering receptor expressed on myeloid cells-2 (TREM2) is a transmembrane of the immunoglobulin superfamily and crucial signaling hub for multiple pathological pathways that mediate immunity. Although increasing evidence supports vital role TREM2 in tumorigenesis some cancers, no systematic pan-cancer analysis available. Thus, we aimed to explore prognostic value, investigate potential immunological functions, across 33 cancer types. Based datasets from The Cancer Genome Atlas, Cell Line...
The activity and survival of retinal photoreceptors depend on support functions performed by the pigment epithelium (RPE) oxygen nutrients delivered blood vessels in underlying choroid. By combining single-cell bulk RNA sequencing, we categorized mouse RPE/choroid cell types characterized tissue-specific transcriptomic features choroidal endothelial cells. We found that endothelium adjacent to RPE expresses high levels Indian Hedgehog identified its downstream target as stromal GLI1+...
Growing evidence correlated changes in bioactive sphingolipids, particularly S1P (sphingosine-1-phosphate) and ceramides, with coronary artery diseases. Furthermore, specific plasma ceramide species can predict major cardiovascular events. Dysfunction of the endothelium lining lesion-prone areas plays a pivotal role atherosclerosis. Yet, how sphingolipid metabolism signaling change contribute to endothelial dysfunction atherosclerosis remain poorly understood.
The WNT pathway is a fundamental regulator of intestinal homeostasis, and hyperactivation signaling the major oncogenic driver in colorectal cancer. To date, there are no described mechanisms that bypass dependence tumors. Here, we show although suppression blocks tumor growth most organoid vivo cancer models, accumulation cancer-associated genetic alterations enables drug resistance WNT-independent growth. In epithelial cells harboring mutations KRAS or BRAF, together with disruption TP53...
Abstract Tumor heterogeneity is common in cancer, however recent studies have applied single gene expression signatures to classify bladder cancers into distinct subtypes. Such stratification assumes that a predominant transcriptomic signature sufficient predict progression kinetics, patient survival and treatment response. We hypothesize such static classification ignores intra-tumoral the potential for cellular plasticity occurring during disease development. conducted cell transcriptome...
Abstract IRE1α-XBP1 signaling is emerging as a central orchestrator of malignant progression and immunosuppression in various cancer types. Employing computational XBP1s detection method applied to TCGA datasets, we demonstrate that expression the mRNA isoform predicts poor survival non-small cell lung (NSCLC) patients. Ablation IRE1α cells delays tumor extends mouse models NSCLC. This protective effect accompanied by alterations intratumoral immune subsets eliciting durable adaptive...
In the operational planning of electric power communication networks, a well-structured service scheduling scheme based on established network topology can significantly enhance risk prevention capabilities these networks. Since routing policies directly influence data transmission paths, optimization serves as an effective strategy for improving performance by mitigating risks and threats. This paper introduces Intelligent Tuning Method Service Scheduling in Electric Power Communication...
Abstract Aggregation of β‐amyloid (Aβ) is implicated in the pathology Alzheimer's disease. Development a robust strategy to detect Aβ oligomeric intermediates, which have been identified as significant toxic agents, would be highly beneficial screening drug candidates well enhancing our understanding oligomerization. Rapid, specific and quantitative detection, currently unavailable, preferred for accurate reliable probing transient oligomers. Here, we report development novel peptide probe,...
Abstract T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive and often incurable disease. To uncover therapeutic vulnerabilities, we first developed T-ALL patient–derived tumor xenografts (PDXs) exposed PDX cells to a library of 433 clinical-stage compounds in vitro. We identified 39 broadly active drugs with antileukemia activity. Because endothelial (ECs) can alter drug responses T-ALL, EC/T-ALL coculture system. found that ECs provide protumorigenic signals mitigate PDXs. Whereas...
Abstract Background Morphological and functional alterations in aging reproductive organs result decreased male fertility. The epididymis functions as the transition region for post-testicular sperm maturation. And we have previously demonstrated that epididymal initial segment (IS), a of tract essential maturation capacitation, undergoes considerable histological changes chronic immune activation mice during aging. However, local aging-associated cellular molecular aged IS are poorly...
Aggregation of β-amyloid (Aβ) is implicated in the pathology Alzheimer's disease (AD). A considerable amount data has identified soluble Aβ oligomers as potentially significant toxic agents. Rapid, specific and quantitative detection preferred for accurate profiling structurally unstable well implementation high-throughput assays pharmaceutical applications. PG46 an engineered variant, constructed by integrating self-recognition sequences with conformation-sensitive biarsenical fluorescent...
We engineered the structural flexibility of an α synuclein (αS) variant, PG65, together with conformation-sensitive fluorescence to create a molecular probe for rapid, specific and quantitative detection αS oligomers, which are major toxic aggregate forms in Parkinson's disease.
Quercetin is a bioflavonoid with potential antioxidant properties. However, the mechanisms underlying its effects remain unclear. Herein, we focused on integrating long noncoding RNA (lncRNA), microRNA (miRNA), and messenger (mRNA) sequencing of PC-12 cells treated quercetin. We hydrogen peroxide to generate validated oxidative damage model. evaluated quercetin established lncRNA, miRNA, mRNA profiles these cells. Gene Ontology Kyoto Encyclopedia Genes Genomes analyses RNAs were conducted...
Abstract Background Triacylglycerol (TAG) is an important storage lipid in organisms, depending on the degree of unsaturation fatty acid molecules attached to glycerol; it usually used as feedstock for nutrition or biodiesel. However, mechanism assembly saturated acids (SFAs) polyunsaturated (PUFAs) into TAGs remains unclear industrial oleaginous microorganism. Results Diacylglycerol acyltransferase (DGAT) a key enzyme TAG synthesis. Hence, ex vivo (in yeast), and functions four DGAT2s...
In order to explore the high performance bivalent DNA-based vaccine against schistosomes, SjFABP and Sj26GST were selected used construct a vaccine. Two strategies DNA first strategy, plasmid encoding antigen in secreted form was used, while other, truncated of targeted cell surface used. Various parameters, including antibody cytokine response, proliferation, histopathological examination, characterization T subsets evaluate type immune response level protection challenge infection....
luxS-mediated autoinducer-2 (AI-2) directly or indirectly regulates important physiologic function in a variety of bacteria, including bioluminescent effect, antimicrobial resistance, virulence factor control, biofilm structure stability and so on. In this study, the regulation susceptibility to antimicrobials by luxS/AI-2 was investigated Streptococcus agalactiae. A luxS- knockout mutant strain named SX1 constructed homologous recombination from S. agalactiae CNEP110823 (wild type strain),...
Niche-derived growth factors support self-renewal of mouse spermatogonial stem and progenitor cells through ERK MAPK signaling other pathways. At the same time, dysregulated factor-dependent has been associated with loss cell activity aberrant differentiation. We hypothesized that factor pathway in is tightly regulated within a narrow range distinct intracellular negative feedback regulators. Evaluation candidate extracellular signal-regulated kinase (ERK) mitogen-activated protein...