A5089780338- Immunotherapy and Immune Responses
- Cancer Immunotherapy and Biomarkers
- Advanced Breast Cancer Therapies
- Immune Cell Function and Interaction
- Cancer-related Molecular Pathways
- CAR-T cell therapy research
- Autophagy in Disease and Therapy
- Cancer Cells and Metastasis
- PARP inhibition in cancer therapy
- Cancer Research and Treatments
- RNA Interference and Gene Delivery
- interferon and immune responses
- Cell death mechanisms and regulation
- Breast Cancer Treatment Studies
- Virus-based gene therapy research
- Immune Response and Inflammation
- Endoplasmic Reticulum Stress and Disease
- Cancer, Stress, Anesthesia, and Immune Response
- Monoclonal and Polyclonal Antibodies Research
- Effects of Radiation Exposure
- Adenosine and Purinergic Signaling
- RNA regulation and disease
- Bacteriophages and microbial interactions
- DNA Repair Mechanisms
- Lung Cancer Research Studies
Cornell University
2019-2025
Weill Cornell Medicine
2021-2025
Centre de Recherche des Cordeliers
2014-2021
Inserm
2014-2021
Institut Gustave Roussy
2014-2021
Université Paris-Saclay
2014-2021
Université Paris Cité
2014-2021
Sorbonne Université
2015-2021
La Ligue Contre le Cancer
2014-2020
Délégation Paris 5
2014-2018
Caspase 3 (CASP3) has a key role in the execution of apoptosis, and many cancer cells are believed to disable CASP3 as mechanism resistance cytotoxic therapeutics. Alongside, regulates stress-responsive immunomodulatory pathways, including secretion type I interferon (IFN). Here, we report that mouse mammary carcinoma TSA lacking Casp3 or subjected chemical caspase inhibition were sensitive cytostatic effects radiation therapy (RT) vitro their control counterparts, yet secreted increased...
Abstract Hormone receptor (HR) + breast cancer (BC) causes most BC-related deaths, calling for improved therapeutic approaches. Despite expectations, immune checkpoint blockers (ICBs) are poorly active in patients with HR BC, part reflecting the lack of preclinical models that recapitulate disease progression immunocompetent hosts. We demonstrate mammary tumors driven by medroxyprogesterone acetate (M) and 7,12-dimethylbenz[a]anthracene (D) several key features human luminal B HER2 −...
Abstract Purpose: Recent preclinical data suggest that cyclin-dependent kinase 4/6 (CDK4/6) inhibition may be harnessed to sensitize estrogen receptor–positive (ER+) breast cancer radiotherapy. However, these findings were obtained in human ER+ cell lines exposed subclinical doses of CDK4/6 inhibitors with limited attention treatment schedule. We investigated the activity radiotherapy combined prototypic inhibitor palbociclib placing emphasis on therapeutic Experimental Design: and various...
Oncolytic viruses are natural or genetically modified viral species that selectively infect and kill neoplastic cells. Such an innate exogenously conferred specificity has generated considerable interest around the possibility to employ oncolytic as highly targeted agents would mediate cancer cell-autonomous anticancer effects. Accumulating evidence, however, suggests therapeutic potential of virotherapy is not a simple consequence cytopathic effect, but strongly relies on induction...
In a series of 248 tumor samples obtained from image-guided biopsies patients diagnosed with ductal carcinoma in situ the breast, we attempted to identify biomarkers that predict microinfiltration at definitive surgery or relapse during follow-up. For this, used immunohistochemical methods, followed by automated image analyses, measure mean diameter nuclei (which correlates ploidy), phosphorylation eukaryotic initiation factor 2α (eIF2α, which reflects endoplasmic reticulum stress) as well...
Cholangiocarcinoma (CCA) results from the malignant transformation of cholangiocytes. Primary sclerosing cholangitis (PSC) and primary biliary (PBC) are chronic diseases in which cholangiocytes primarily damaged. Although PSC is an inflammatory condition predisposing to CCA, CCA almost never found autoimmune context PBC. Here, we hypothesized that PBC might favor immunosurveillance. In preclinical murine models challenged with syngeneic (but not PSC) reduced frequency development delayed...
One type of anticancer vaccine relies on the administration DNA constructs encoding one or multiple tumor-associated antigens (TAAs). The ultimate objective these preparations, which can be naked vectored by non-pathogenic viruses, bacteria yeast cells, is to drive synthesis TAAs in context an immunostimulatory milieu, resulting (re-)elicitation a tumor-targeting immune response. In spite encouraging preclinical results, clinical efficacy DNA-based vaccines employed as standalone...
Abstract Background Preclinical evidence from us and others demonstrates that the anticancer effects of cyclin-dependent kinase 4/6 (CDK4/6) inhibitors can be enhanced with focal radiation therapy (RT), but only when RT is delivered prior to (rather than after) CDK4/6 inhibition. Depending on tumor model, cellular senescence (an irreversible proliferative arrest associated secretion numerous bioactive factors) has been attributed beneficial or detrimental response treatment. As both elicit...