A5052311485- Radiopharmaceutical Chemistry and Applications
- Synthesis and Biological Evaluation
- Medical Imaging Techniques and Applications
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Lanthanide and Transition Metal Complexes
- Molecular Junctions and Nanostructures
- Angiogenesis and VEGF in Cancer
- RNA Interference and Gene Delivery
- Nanoplatforms for cancer theranostics
- Fibroblast Growth Factor Research
- Cancer therapeutics and mechanisms
- Cancer-related Molecular Pathways
- Structural and Chemical Analysis of Organic and Inorganic Compounds
- Cancer, Hypoxia, and Metabolism
- Surface and Thin Film Phenomena
- Nanoparticle-Based Drug Delivery
- Cardiac Imaging and Diagnostics
- Click Chemistry and Applications
- Cell death mechanisms and regulation
- Catalytic C–H Functionalization Methods
- Advanced MRI Techniques and Applications
- Cancer Treatment and Pharmacology
- Chronic Lymphocytic Leukemia Research
- Synthesis and bioactivity of alkaloids
Nanjing University of Chinese Medicine
2016-2024
Jiangsu Provincial Academy of Traditional Chinese Medicine
2015-2024
China Pharmaceutical University
2011-2023
Jiangsu Province Hospital
2016-2023
Florida International University
1996-1999
From the perspective of philology, this study is first to explore author information,manuscript content,and literary value unpublished and unique manuscript He Yao Zong Bu. Firstly, by examining physician's birth year, residence, social interactions handwriting style, it can be determined that manuscript's Yang Shoushan, a renowned doctor Shicai School Wumen Medical during Qing Dynasty. Bu one two traceable manuscripts currently known have been handed down Yang. Secondly,the main content...
A series of 1-H-pyrazole-3-carboxamide derivatives have been designed and synthesized that exhibit excellent FLT3 CDK inhibition antiproliferative activities. structure-activity-relationship study illustrates the incorporation a pyrimidine-fused heterocycle at position 4 pyrazole is critical for inhibition. Compound 50 (FN-1501), which possesses potent inhibitory activities against FLT3, CDK2, CDK4, CDK6 with IC50 values in nanomolar range, shows MV4-11 cells (IC50: 0.008 μM), correlates...
The formation and structure of 2,2'-bipyridine (22BPY) 4,4'-bipyridine (44BPY) monolayers on Au(111) substrate have been studied as a function the potential. At high potentials, both molecules adsorb onto stand vertically with their nitrogen atoms facing Au(111). standing stack, like rolls coins, into polymer-like chains which pack closely in parallel to form ordered monolayers. Decreasing potential critical value, 22BPY become randomly oriented via reversible order−disorder phase...
A [3 + 4] annulation of isatin N,N′-cyclic azomethine imine 1,3-dipole 1 with in situ-generated aza-oQMs has been established for the synthesis spirooxindole seven-membered scaffolds. These highly functionalized scaffolds were assembled moderate to good yields (up 96% yield). The novel displayed antitumor activities, which represented promising lead compounds drug discovery.
Abnormal expression of programmed death-ligand 1 (PD-L1) on cancer cells contributes to immune escape in hepatocellular carcinoma (HCC). Paeoniflorin has been shown inhibit the growth HCC; however, whether its inhibitory effect involves reducing PD-L1 HCC remains unknown. We investigated antitumor effects paeoniflorin and potential regulatory mechanisms HCC. The tumor immunity were determined H22-xenografted mice DEN-induced rats. Small interfering RNA against suppressor cytokine signaling 3...
Paris polyphylla, a traditional antipyretic-detoxicate chinese medicinal herb, has been applied extensively in cancer treatments for nearly 2000 years. The purpose of the present study is to evaluate potential anti-osteosarcoma effects polyphylla ethanol extract (PPEE) and investigate its underlying mechanisms. antiproliferation activity PPEE was tested on 143B, MG-63, U-2 OS hFOB1.19 cells using MTT assay. pro-apoptotic cell cycle arrest were confirmed by Hoechst 33342 staining flow...
Assessment of myocardial viability is deemed necessary to aid in clinical decision making whether recommend revascularization therapy for patients with infarction (MI). Dianthraquinones such as hypericin (Hyp) selectively accumulate necrotic myocardium, but were unsuitable early imaging after administration assess viability. Since dianthraquinones can be composed by coupling two molecules monomeric anthraquinone and the active center found splitting chemical structure, we propose that...
A rapid and accurate identification of necrotic myocardium is great importance for diagnosis, risk stratification, clinical decision-making, prognosis evaluation myocardial infarction. Here, we explored technetium-99m labeled rhein derivatives imaging the myocardium. Three hydrazinonicotinic acid-linker-rhein (HYNIC-linker-rhein) were synthesized, then, these synthetic compounds with using ethylenediaminediacetic acid (EDDA) tricine as coligands [99mTc(EDDA)-HYNIC-linker-rhein]. The necrosis...
A base-mediated [2 + 4] annulation of <italic>in situ</italic> formed azaoxyallyl cations with generated aza-<italic>o</italic>QMs has been realized.
Cell death plays important roles in living organisms and is a hallmark of numerous disorders such as cardiovascular diseases, sepsis acute pancreatitis. Moreover, cell also pivotal role the treatment certain for example, cancer. Noninvasive visualization contributes to gained insight into development individualized plans, evaluation responses, prediction patient prognosis. On other hand, can be targeted diseases. Although there are many ways die, only apoptosis necrosis have been extensively...
This study aimed to assess the effects of triterpene extract Cyclocarya paliurus (Batal.) Iljinskaja (CPT) on diabetes-induced hepatic inflammation, and unveil underlying mechanisms. Diabetes in db/db mice was alleviated after CPT administration, as assessed by oral glucose tolerance test. In addition, treatment with dramatically reduced serum insulin, aspartate amino-transaminase, alanine aminotransferase, triglyceride total cholesterol amounts. Besides, levels interleukin (IL)-1β, IL-6...
Myocardial infarction (MI) leads to substantial morbidity and mortality around the world. Accurate assessment of myocardial viability is essential assist therapies improve patient outcomes. (131)I-hypericin dicarboxylic acid ((131)I-HDA) was synthesized evaluated as a potential diagnostic agent for earlier myocardium compared its preceding counterpart ((131)I-Hyp) with strong hydrophobic property, long plasma half-life, high uptake in mononuclear phagocyte system (MPS). Herein, HDA...
Metal-free C(sp<sup>3</sup>)–H alkylation of an isatin <italic>N</italic>,<italic>N</italic>′-cyclic azomethine imine 1,3-dipole.
A one-pot, two-step protocol for the synthesis of libraries remarkable functionalized sulfone analogues 9b,10,10a,10b-tetrahydro-1H-cyclopropa[c][1,4]thiazino[4,3-a]quinolines is described. class various molecular skeletons was obtained by cyclopropanation quinolinium zwitterionic thiolates. The reaction pathway involves formation a [2 + 1] cycloaddition intermediate followed [5 cycloaddition.
Four novel 1H-pyrazole-3-carboxamide derivatives were synthesized, and their antiproliferative effect on cancer cells, kinase inhibition, in particular, the DNA-binding interaction investigated to interpret antitumor mechanisms. A DNA minor groove binding model was developed, energy predicted for compounds. In consistence with prediction, ability determined by electronic absorption spectroscopy under physiological conditions compounds, further verified viscosity measurement. One compound...
Early and accurate assessment of therapeutic response to anticancer therapy plays an important role in determining treatment planning patient management clinic. Magnetic rseonance imaging (MRI) necrosis that occurs after cancer therapies provides chances for that. Here, we reported three novel MRI contrast agents, GdL1, GdL2, GdL3, by conjugating rhein with gadolinium 2-[4,7,10-tris(carboxymethyl)-1,4,7,10-tetraazacyclododec-1-yl]acetic acid (Gd-DOTA) through different linkers. The T1...
A facile and efficient cyclization of <italic>N</italic>-alkoxy α-halogenoacetamides with <italic>N</italic>-(2-chloromethyl)aryl amides has been achieved for rapid access to 1,2,4,5-tetrahydro-1,4-benzodiazepine-3-one derivatives (up 95% yield).
A [3 + 2] annulation/C-arylation of isatin N,N'-cyclic azomethine imine 1,3-dipole 1 with in situ generated arynes has been established for the synthesis 3,3-disubstituted oxindole scaffolds. These highly functionalized scaffolds were assembled moderate yields (up to 85% yield). The novel spirooxindole displayed antitumor activities, which represented promising lead compounds drug discovery.
An innovative anticancer approach targeted to necrotic tissues, which serves as a noncancerous and generic anchor, may present breakthrough. Necrosis avid agents with flat conjugate aromatic structure selectively accumulate in but they easily form aggregates that undesirably distribute normal tissues. In this study, skyrin, dianthraquinone compound smaller distorted π-cores thus decreased compared hypericin (Hyp), was designed target necrosis for tumor therapy. Aggregation studies of skyrin...