A5101461430- Air Quality and Health Impacts
- Climate Change and Health Impacts
- MicroRNA in disease regulation
- Heavy Metal Exposure and Toxicity
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Sperm and Testicular Function
- Global Health Care Issues
- Effects and risks of endocrine disrupting chemicals
- Thermoregulation and physiological responses
- Toxic Organic Pollutants Impact
- Trace Elements in Health
- Heme Oxygenase-1 and Carbon Monoxide
- Reproductive Biology and Fertility
- Air Quality Monitoring and Forecasting
- Extracellular vesicles in disease
- Liver Disease Diagnosis and Treatment
- Gout, Hyperuricemia, Uric Acid
- Diet and metabolism studies
- COVID-19 epidemiological studies
- Adipokines, Inflammation, and Metabolic Diseases
- Heart Rate Variability and Autonomic Control
- COVID-19 Clinical Research Studies
- Alcohol Consumption and Health Effects
- Carcinogens and Genotoxicity Assessment
Shenzhen Center for Disease Control and Prevention
2016-2025
Shenzhen University
2023-2025
Shenzhen University Health Science Center
2024-2025
Ningbo University of Technology
2024
Gannan Normal University
2024
Toronto Metropolitan University
2024
Shantou University
2023
Shantou University Medical College
2023
Nanchang University
2023
Second Affiliated Hospital of Nanchang University
2023
Abstract Background Rapid spread of SARS-CoV-2 in Wuhan prompted heightened surveillance Shenzhen and elsewhere China. The resulting data provide a rare opportunity to measure key metrics disease course, transmission, the impact control. Methods CDC identified 391 cases from January 14 February 12, 2020 1286 close contacts. We compare through symptomatic contact tracing, estimate time symptom onset confirmation, isolation, hospitalization. transmission analyze factors influencing risk....
Extreme temperature events (ETEs), including heat wave and cold spell, have been linked to myocardial infarction (MI) morbidity; however, their effects on MI mortality are less clear. Although ambient fine particulate matter (PM
Background Air pollution has been associated with an increased risk of cardiopulmonary mortality and decreased heart rate variability (HRV). However, it is unclear whether coke oven emissions (COEs) polycyclic aromatic hydrocarbons (PAHs) are HRV. Objectives Our goal in the present study was to investigate association exposure COEs urinary metabolite profiles PAHs HRV workers. Methods We measured benzene soluble matter, carbon monoxide, sulfur dioxide, particulate matters, at different...
BackgroundEpidemiological studies have suggested an association between external estimates of exposure to metals in air particles and altered heart rate variability (HRV). However, on the internal assessments HRV are limited.ObjectivesThe purpose this study was examine potential urinary among residents urban community Wuhan, China.MethodsWe performed a cross-sectional analysis 23 5-min indices (SDNN, standard deviation normal-to-normal intervals; r-MSSD, root mean square successive...
Reprogrammed energy metabolism as an emerging hallmark of cancer has recently drawn special attention since it facilitate cell growth and proliferation. Recently, long noncoding RNAs (lncRNAs) have been served key regulators implicated in tumor development progression by promoting proliferation, invasion metastasis. However, the associations lncRNAs with cellular lung (LC) need to be clarified. Here, we conducted bioinformatics analysis found insulin-like factor binding protein 4–1...
Ischemic stroke (IS) is a major cause of morbidity and mortality globally. Environmental exposure to metals may be linked the risk IS, but association remains uncertain in Chinese populations. The present study aimed examine associations between concentrations 11 (aluminum, arsenic, cadmium, cobalt, copper, iron, manganese, molybdenum, selenium, thallium, zinc) plasma IS population. A total 1277 pairs newly diagnosed patients controls matched on age (±3 years) sex were recruited our study....
Abstract Background Stroke, especially ischemic stroke (IS), has been a severe public health problem around the world. However, association between air pollution and remains ambiguous. Methods A total of 63, 997 IS cases aged 18 years or above in Shenzhen were collected from 2008 to 2014. We used time-stratified case-crossover design combining with distributed lag nonlinear model (DLNM) estimate onset. Furthermore, this study explored variability across gender age groups. Results The...
Background and Purpose- Circulating metals synchronously reflect multiple metal exposures from both natural anthropogenic sources, which may be linked with the risk of stroke. However, there is a lack prospective studies investigating associations incident Methods- We performed nested case-control study within ongoing Dongfeng-Tongji cohort launched in 2008. A total 1304 stroke cases (1035 ischemic strokes 269 hemorrhagic strokes) were prospectively identified by December 31, 2016, matched...
Metal exposures have been reported to be related the progress of metabolic syndrome (MetS), however, currents results were still controversial, and evidence about effect multi-metal exposure on MetS limited. In this study, we intended evaluate relationships between metal mixture prevalence in a mid-aged older population China.The plasma levels 13 metals (aluminum, magnesium, calcium, iron, manganese, cobalt, copper, arsenic, zinc, selenium, cadmium, molybdenum thallium) detected by...
Plasma lipid levels are important risk factors for cardiovascular disease and influenced by genetic environmental factors. Recent genome wide association studies (GWAS) have identified several lipid-associated loci, but these loci been primarily in European populations. In order to identify markers a Chinese population analyze the heterogeneity between Europeans Asians, especially Chinese, we performed meta-analysis of two on four common traits including total cholesterol (TC), triglycerides...
All humans are now co-exposed to multiple toxic chemicals, among which metals and polycyclic aromatic hydrocarbons (PAHs) of special concern as they often present at high levels in various human environments. They can also induce similar early health damage, such genetic oxidative stress, heart rate variability (HRV). Exposure metals, PAHs, their combined pollutants alter microRNA (miRNA) expression patterns. To explore the associations metal-PAH co-exposure with miRNA expression, associated...
Ubiquitous polycyclic aromatic hydrocarbons (PAHs) have been shown to alter gene expression patterns and elevate micronuclei (MN) frequency, but the underlying mechanisms are largely unknown. MicroRNAs (miRNAs) key regulators that may be influenced by PAH exposures mediate their effects on MN frequency.We sought identify PAH-associated miRNAs evaluate associations with performed a two-stage study in healthy male coke oven workers associated quantified using urinary monohydroxy-PAHs plasma...
A case-crossover study among 511,767 cardiovascular disease (CVD) deaths in Jiangsu province, China, during 2015–2021 was conducted to assess the association of exposure ambient ozone (O3) and heat wave with CVD mortality explore their possible interactions. Heat defined as extreme high temperature for at least two consecutive days. Grid-level waves were by multiple combinations apparent thresholds durations. Residential O3 exposures assessed using grid data sets (spatial resolution: 1 km ×...
Uric acid (UA) is a complex phenotype influenced by both genetic and environmental factors as well their interactions. Current genome-wide association studies (GWASs) have identified variety of determinants UA in Europeans; however, such Asians, especially Chinese populations remain limited.A two-stage GWAS was performed to identify single nucleotide polymorphisms (SNPs) that were associated with serum uric population 12,281 participants (GWAS discovery stage included 1452 from the...
Di(2-ethylhexyl) phthalate (DEHP) is reported to cause obesity and hypothyroidism in both humans rodents, but the underlying mechanisms were largely unknown. This study was designed clarify effects of DEHP on pathogenesis discover relationship between them.Male C3H/He mice treated with for 5 weeks, body weight, food intake, temperature recorded during exposure. After exposure, key organs serum analyzed by Q-PCR, Western blot, ELISA.DEHP induced significant weight gain adipogenesis all...
Background— Circulating microRNAs ( miRNAs) are emerging as novel disease biomarkers. We aimed to explore the association between circulating miRNAs and occurrence of acute myocardial infarction (AMI) in Chinese populations. Methods Results— In discovery stage, plasma 20 patients with AMI controls were pooled respectively profiled by massively parallel sequencing. Seventy-seven showed differential expression. Selected validated 178 198 using quantitative reverse transcriptase polymerase...
Circulating microRNAs (miRNAs) are emerging as novel disease biomarkers. Using a miRNA microarray, we previously showed that the whole blood level of let-7e-5p was significantly higher in ischemic stroke patients than control subjects. However, association between expression and occurrence remains unknown. In this study, validated levels two case-control populations using TaqMan assays further investigated potential targets let-7e-5p. The results suggest with controls (p<0.05). Higher were...
microRNA (miRNA) plays a role in the pathogenesis of ischemic stroke, and single nucleotide polymorphisms miRNA genes may contribute to disease susceptibility. However, effect miR-146a, miR-196a2, miR-499 on stroke susceptibility has been rarely reported. Using TaqMan assay, we evaluated association hsa-miR-146a/rs2910164, hsa-miR-196a2/rs11614913, hsa-miR-499/rs3746444 with risk Chinese population 531 patients control subjects. Rs2910164 C/G genotypes were significantly associated increased...