A5102739225- COVID-19 Clinical Research Studies
- Heat shock proteins research
- Long-Term Effects of COVID-19
- Cardiac Ischemia and Reperfusion
- Traditional Chinese Medicine Analysis
- COVID-19 and healthcare impacts
- SARS-CoV-2 and COVID-19 Research
- Endoplasmic Reticulum Stress and Disease
- Calpain Protease Function and Regulation
- Cardiovascular Function and Risk Factors
- Apelin-related biomedical research
- Biomarkers in Disease Mechanisms
- Atherosclerosis and Cardiovascular Diseases
- Cardiac Imaging and Diagnostics
- Regulation of Appetite and Obesity
- Parathyroid Disorders and Treatments
- NF-κB Signaling Pathways
- Mitochondrial Function and Pathology
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Cerebrovascular and Carotid Artery Diseases
- Cardiovascular Issues in Pregnancy
- Galectins and Cancer Biology
- Sepsis Diagnosis and Treatment
- Cardiac Arrest and Resuscitation
- Adipokines, Inflammation, and Metabolic Diseases
Huazhong University of Science and Technology
2015-2024
Tongji Hospital
2015-2024
Chongqing Medical University
2023
Second Affiliated Hospital of Chongqing Medical University
2023
Dalian Medical University
2023
Union Hospital
2014
Harvard University
2008-2014
Ministry of Ecology and Environment
2014
University of Sheffield
2008
Union Hospital
2008
Objective: To analyze the clinical characteristics of severe or critically ill patients with novel coronavirus pneumonia (COVID-19), and evaluate impact complicated myocardial injury on prognosis these patients. Methods: A retrospective study was conducted in 54 who admitted to Tongji hospital from February 3, 2020 24, met criteria critical conditions COVID-19. The mortality rate were analyzed compared between without injury, which defined 3 times higher serum cardiac troponin value....
Background— Although heat shock protein 60 (Hsp60) is implicated in the pathogenesis of atherosclerosis, its role coronary heart disease (CHD) uncertain. This study explored influence circulating Hsp60 on CHD a large case-control study, as well impact acute myocardial infarction levels prospective study. Methods and Results— Plasma anti-Hsp60 antibody were determined by immunoassay. In (1003 patients with CHD, 1003 matched control subjects), higher related to (OR comparing extreme...
Leptin is a peptide hormone primarily involved in the regulation of food intake and energy expenditure. Recent studies have suggested that leptin one risk factors for cardiovascular diseases including atherosclerosis hypertension. Vascular smooth muscle cells (VSMCs) play vital role arterial intimal thickening vascular remodeling. In this study, we investigated effect on VSMC cell-cycle possible pathway. We found stimulated proliferation increased cell progression to S G2/M phases. The...
Background— Circulating microRNAs ( miRNAs) are emerging as novel disease biomarkers. We aimed to explore the association between circulating miRNAs and occurrence of acute myocardial infarction (AMI) in Chinese populations. Methods Results— In discovery stage, plasma 20 patients with AMI controls were pooled respectively profiled by massively parallel sequencing. Seventy-seven showed differential expression. Selected validated 178 198 using quantitative reverse transcriptase polymerase...
Background HSP70 plays crucial roles in endothelial cell apoptosis, which is involved the early phase and progress of coronary heart disease (CHD). However, association between polymorphisms genes risk CHD still remains unclear. Our aim was to determine whether genetic variants HSPA1A gene are associated with CHD. Methodology/Principal Findings By resequencing genotyping, associations 2 single nucleotide (SNPs) +190G/C (rs1043618) −110A/C (rs1008438) were determined a 1,003 pairs...
Acute aortic dissection (AAD) is a life-threatening disease. Despite the higher risk of mortality, currently there are no effective therapies that can ameliorate AAD development or progression. Identification meaningful clusters co-expressed genes representative biomarkers for may help to identify new pathomechanisms and foster therapies. To this end, we performed weighted gene co-expression network analysis (WGCNA) calculated module-trait correlations based on public microarray dataset (GSE...
Abstract Idiopathic pulmonary arterial hypertension (IPAH) is a severe cardiovascular disease that serious threat to human life. However, the specific diagnostic biomarkers have not been fully clarified and candidate regulatory targets for IPAH identified. The aim of this study was explore potential possible IPAH. We performed weighted gene coexpression network analysis calculated module‐trait correlations based on public microarray data set (GSE703) six modules were found be related Two...
Cytochrome P450 epoyxgenase 2J2 and epoxyeicosatrienoic acids (EETs) are known to protect against cardiac hypertrophy heart failure, which involve the activation of 5'-AMP-activated protein kinase (AMPK) Akt. Although functional roles AMPK Akt well established, significance cross talk between them in development antihypertrophy CYP2J2 EETs remains unclear. We investigated whether its metabolites protected by activating AMPKα2 Akt1. Moreover, we tested enhanced phosphorylated Akt1 (p-Akt1),...
Background There is ample evidence that Hsp70 takes part in the progress of coronary heart disease (CHD). This implies genetic variants genes such as HSPA8 (HSC70) gene might contribute to development CHD. The present study aimed investigate whether certain are associated with CHD Han Chinese people. Methodology/Principal Findings A total 2006 subjects (1003 cases and 1003 age- sex- matched healthy controls) were recruited. Genetic identified by sequencing 60 unrelated Chinese. Four tag...
Abstract To determine the incidence of acute cardiac injury (ACI), factors associated with ACI and in-hospital mortality in patients COVID-19, especially severe patients. All consecutive in-patients laboratory-confirmed COVID-19 from Tongji Hospital Wuhan during February 1 March 29, 2020 were included. The demographic, clinical characteristics, laboratory, radiological treatment data collected. Univariate Firth logistic regression analyses used to identify mortality, Kaplan–Meier method was...
Previous published prognostic models for COVID-19 patients have been suggested to be prone bias due unrepresentativeness of patient population, lack external validation, inappropriate statistical analyses, or poor reporting. A high-quality and easy-to-use model predict in-hospital mortality could support physicians make better clinical decisions. Fine-Gray were used derive a (treating discharged alive from hospital as the competing event) in using two retrospective cohorts (n = 1008) Wuhan,...
Abstract Aims Transthyretin cardiac amyloidosis (ATTR‐CA) has been realized as an important cause of heart failure with preserved ejection fraction (HFpEF). We aim to provide insights into its prevalence in Chinese HFpEF patients, which is not known date, using increased wall thickness (IWT) score by echocardiography. Methods Consecutive patients (EF ≥ 40%) and IWT (≥12 mm) were prospectively screened. Echocardiography was performed, the incorporated relative thickness, E/e′ ratio,...
Abstract OBJECTIVE To develop and validate a prognostic model for in-hospital mortality in COVID-19 patients using routinely collected demographic clinical characteristics. DESIGN Multicenter, retrospective cohort study. SETTING Jinyintan Hospital, Union Tongji Hosptial Wuhan, China. PARTICIPANTS A pooled derivation of 1008 from Hospital Wuhan an external validation 1031 MAIN OUTCOME MEASURES Outcome interest was mortality, treating discharged alive hospital as the competing event. Fine-Gray...
Oxysterols induce apoptosis in vascular endothelial cells vitro, but it is not clear whether they do so vivo. We intravenously injected an oxysterol, cholestan-3β, 5α, 6β-triol, into rats and quantitatively analyzed cell the aorta. Oxysterol significantly promoted a time- dose-dependent fashion. The had increased 4.5-fold 6 hrs after injection, returned to background level at 48 hrs. An extract of Chinese herb Danshen as well probucol abolished triol-induced vitro Since apoptotic are quickly...
High levels of circulating heat shock protein 60 (Hsp60) and antibody to human Hsp60 have been associated with greater risk coronary heart disease (CHD) in several studies, but associations between polymorphisms the hsp60 gene CHD not investigated. By resequencing DNA from 30 unrelated Han Chinese using HapMap Phase I data gene, we selected four tagging single nucleotide (tagSNPs) named rs2340690, rs788016, rs2305560, rs2565163, determined their frequencies 1,003 patients age-...
Several studies have suggested an association between antibody to human heat shock protein 60 (anti-Hsp60) and coronary atherosclerosis, but the results been inconsistent. The aim of this study was investigate anti-Hsp60 heart disease (CHD) determine whether anti-Hsp60, hypertension, diabetes joint effects on CHD risk.We measured concentrations in 1003 patients age- sex-matched control subjects without events.Concentrations were significantly higher than controls. Increasing associated with...
Abstract Objectives The main aim of our study is to observe clinical characteristics and effects antihypertensive drugs in different hospitalized populations, further provide evidence explore causes specific markers the aggravation COVID-19 patients with underlying hypertension. Design This was a retrospective cohort focusing on data inpatients admitted at early stage pandemic. Setting A single center conducted Tongji Hospital, Medical College Huazhong university Science Technology (Wuhan,...
Objective: To investigate the role of Maresin1 (MaR1) in hepatic ischemia-reperfusion injury (HIRI). Methods: The HIRI model was established and randomly divided into a sham operation group (Sham group), an (IR MaR1 (MaR1+IR group). 80ng intravenously injected each mouse's tail veins 0.5h before anesthesia. left middle lobe arteries portal were opened clamped. blood supply restored after 1h ischemia. After 6h reperfusion, mice sacrificed to collect liver tissue samples. Sham's abdominal wall...
Abstract Rationale Coronavirus disease 2019 (COVID-19) can cause a viral pneumonia together with other extrapulmonary complications. Acute cardiac related injury (ACRI) is common in hospitalized COVID-19 patients. Objective To explain the pathological mechanism of ACRI and improve treatment strategy by retrospectively observing factors associated affecting prognosis at an early stage. Methods 619 patients were from Tongji Hospital, Wuhan. Student’s t test was used for continuous variables...