A5069471551- Wound Healing and Treatments
- Hair Growth and Disorders
- Mesenchymal stem cell research
- Ovarian cancer diagnosis and treatment
- Ferroptosis and cancer prognosis
- Dermatologic Treatments and Research
- Asthma and respiratory diseases
- Dermatology and Skin Diseases
- Renal cell carcinoma treatment
- Cancer, Hypoxia, and Metabolism
- RNA modifications and cancer
- Cellular Mechanics and Interactions
- Skin and Cellular Biology Research
- Cell Adhesion Molecules Research
- Neurogenetic and Muscular Disorders Research
- Immune Response and Inflammation
- Allergic Rhinitis and Sensitization
- Parkinson's Disease Mechanisms and Treatments
- Cancer Mechanisms and Therapy
- Apelin-related biomedical research
- Cancer-related molecular mechanisms research
- Amyotrophic Lateral Sclerosis Research
- Galectins and Cancer Biology
- Signaling Pathways in Disease
- Caveolin-1 and cellular processes
Cleveland Clinic Lerner College of Medicine
2021-2024
Cleveland Clinic
2024
University of Illinois Chicago
2023
Cleveland Research (United States)
2023
Huazhong University of Science and Technology
2017-2022
Tongji Hospital
2017-2022
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease, with poor prognosis and no cure. Substantial evidence implicates inflammation associated oxidative stress as potential mechanism for ALS, especially in patients carrying the SOD1 mutation and, therefore, lacking anti-oxidant defense. The brain particularly vulnerable to oxidation due abundance of polyunsaturated fatty acids, such docosahexaenoic acid (DHA), which can give rise several oxidized metabolites....
Acute aortic dissection (AAD) is a life-threatening disease. Despite the higher risk of mortality, currently there are no effective therapies that can ameliorate AAD development or progression. Identification meaningful clusters co-expressed genes representative biomarkers for may help to identify new pathomechanisms and foster therapies. To this end, we performed weighted gene co-expression network analysis (WGCNA) calculated module-trait correlations based on public microarray dataset (GSE...
Abstract Background Ovarian cancer has greatly endangered and deteriorated female health conditions worldwide. Refinement of predictive biomarkers could enable patient stratification help optimize disease management. Methods RAD51 expression profile, target-disease associations, fitness scores were analyzed in ovarian using bioinformatic analysis. To further identify its role, gene enrichment analysis was performed, a regulatory network constructed. Survival drug sensitivity assay performed...
The etiology of hair loss remains enigmatic, and current remedies remain inadequate. Transcriptome analysis aging follicles uncovered changes in immune pathways, including Toll-like receptors (TLRs). Our findings demonstrate that the maintenance follicle homeostasis regeneration capacity after damage depend on TLR2 stem cells (HFSCs). In healthy follicles, is expressed a cycle-dependent manner governs HFSCs activation by countering inhibitory BMP signaling. Hair obesity exhibit decrease both...
Clear cell renal carcinoma (ccRCC) is the most prevalent kidney cancer worldwide, and appropriate biomarkers facilitate early diagnosis, treatment, prognosis prediction in management. However, an accurate biomarker for ccRCC lacking. This study identified 356 differentially expressed genes tissues compared with normal by integrative analysis of eight datasets. Enrichment unveiled improved adaptation to hypoxia metabolic reprogramming tumor cells. Aldehyde oxidase 1 ( AOX1 ) gene was as a...
Activation of IL-4R (IL-4 receptor) signaling in airway epithelial cells leads to hyperresponsiveness and mucus overproduction asthma. CDH26 (cadherin-26), a cadherin implicated the polarization cells, is upregulated However, role asthma remains unknown. In this study, we demonstrated that Cdh26 deficiency significantly reduced overproduction, hyperresponsiveness, eosinophilia murine model allergic disease. Interestingly, allergen-induced Il-4Rα upregulation epithelium was markedly Cdh26-/-...
Abstract Background Owing to the high morbidity and mortality, ovarian cancer has seriously endangered female health. Development of reliable models can facilitate prognosis monitoring help relieve distress. Methods Using data archived in TCPA TCGA databases, proteins having significant survival effects on patients were screened by univariate Cox regression analysis. Patients with complete information concerning protein expression, survival, clinical variables included. A risk model was then...
The etiology of hair loss remains enigmatic, and current remedies remain inadequate. Transcriptome analysis aging follicles uncovered changes in immune pathways, including Toll-like receptors (TLRs). Our findings demonstrate that the maintenance follicle homeostasis regeneration capacity after damage depends on TLR2 stem cells (HFSCs). In healthy follicles, is expressed a cycle-dependent manner governs HFSCs activation by countering inhibitory BMP signaling. Hair obesity exhibit decrease...
Abstract The etiology of hair loss remains enigmatic, and current remedies remain inadequate. Transcriptome analysis aging follicles uncovered changes in immune pathways, including Toll-like receptors (TLRs). Our findings demonstrate that the maintenance follicle homeostasis regeneration capacity after damage depends on TLR2 stem cells (HFSCs). In healthy follicles, is expressed a cycle-dependent manner governs HFSCs activation by countering inhibitory BMP signaling. Hair obesity exhibit...
The etiology of hair loss remains enigmatic, and current remedies remain inadequate. Transcriptome analysis aging follicles uncovered changes in immune pathways, including Toll-like receptors (TLRs). Our findings demonstrate that the maintenance follicle homeostasis regeneration capacity after damage depend on TLR2 stem cells (HFSCs). In healthy follicles, is expressed a cycle-dependent manner governs HFSCs activation by countering inhibitory BMP signaling. Hair obesity exhibit decrease both...
Abstract Objective It is unclear why adhesion‐dependent cells such as epithelium undergo anoikis without anchorage, while adhesion‐independent blood thrive in suspension. The adhesive machinery of these similar, with the exception Kindlin orthologs, 2 (K2) and 3 (K3). Here we address how Kindlins control cell survival proliferation anchorage‐dependent independent cells. Material Methods To demonstrate opposite roles Kindlin's utilized vivo vitro models K3 K2 knockdown knockin We used human...
The etiology of hair loss remains enigmatic, and current remedies remain inadequate. Transcriptome analysis aging follicles uncovered changes in immune pathways, including Toll-like receptors (TLRs). Our findings demonstrate that the maintenance follicle homeostasis regeneration capacity after damage depends on TLR2 stem cells (HFSCs). In healthy follicles, is expressed a cycle-dependent manner governs HFSCs activation by countering inhibitory BMP signaling. Hair obesity exhibit decrease...