A5101537052- Traditional Chinese Medicine Analysis
- Pharmacological Effects of Natural Compounds
- Flavonoids in Medical Research
- Advanced biosensing and bioanalysis techniques
- Synthesis and biological activity
- Traditional Chinese Medicine Studies
- Natural product bioactivities and synthesis
- Nanoplatforms for cancer theranostics
- Gout, Hyperuricemia, Uric Acid
- Synthesis and Biological Evaluation
- Nanoparticle-Based Drug Delivery
- Diabetes Treatment and Management
- Food Quality and Safety Studies
- Civil and Geotechnical Engineering Research
- Tryptophan and brain disorders
- Chalcogenide Semiconductor Thin Films
- Long-Term Effects of COVID-19
- Kruppel-like factors research
- Drug Solubulity and Delivery Systems
- Diet and metabolism studies
- COVID-19 Clinical Research Studies
- Diabetes and associated disorders
- Genomics, phytochemicals, and oxidative stress
- Biological Activity of Diterpenoids and Biflavonoids
- Cell Adhesion Molecules Research
Kunming Medical University
2025
Indiana University Health
2024
Indiana University – Purdue University Indianapolis
2024
Indiana University Melvin and Bren Simon Comprehensive Cancer Center
2024
First Affiliated Hospital of Henan University
2021-2024
Southwest Jiaotong University
2016-2024
First Affiliated Hospital of Fujian Medical University
2023-2024
Fujian Medical University
2023-2024
Nanjing Medical University
2024
Chengdu Third People's Hospital
2018-2024
Paclitaxel (PTX) is currently the only botanical drug that can control growth of cancer cells. widely used in treatment breast cancer, ovarian uterine non-small cell lung and other cancers.Folate receptor integrin αvβ3 are highly expressed on surface human cells MCF-7. Folic acid arginine-glycine-aspartate (Arg-Gly-Asp, RGD) tripeptide sequence have a high affinity for folate αvβ3, respectively. To enhance effect we constructed RGD peptide dual-targeted (MSNs-NH2-FA-RGD) drug-carrier based...
Purpose: Obesity is currently a major global public health issue. It has been shown by many that gut microbiota and microbial factors regulate the pathogenesis of obesity metabolic abnormalities, but little known about their roles in different degrees obesity. Here, we sought to investigate signatures various severities. Patients Methods: We did this characterizing intestinal microbiome signature Chinese cohort obese patients healthy controls using 16S rRNA gene sequencing. To end, was...
This study aims to establish a comprehensive evaluation system for assessing public health practice teaching quality, addressing the shortcomings of traditional methods. The framework integrates Context, Input, Process, and Product (CIPP) model with Analytic Hierarchy Process (AHP) Entropy Weight Method provide precise balanced weightings indicators. AHP was selected its ability incorporate expert judgment consistency checks, ensuring structured decision-making, while enhances objectivity by...
Unique oil-soluble InP/ZnSe/ZnS QDs with strong visible excitonic and NIR surface defect emissions were synthesized used in multi-scale bioimaging.
Cancer metastasis is a major cause of high mortality in breast cancer. Despite the progress achieved nanomaterial-based treatments, cure rate remains unsatisfactory, owing to their poor biocompatibility and non-specific recognition. Inspired by cell-mimetic strategy, this work, we fabricated an intelligent cell-like nano-prodrug (Dox-MPK@MDL) for lung Specifically, DNA tetrahedron dendrimer was selected act as rigid internal cytoskeleton, then sequentially coated with liposome macrophage...
Concerns associated with the nondegradability of silica (SiO2)-based nanoplatforms have hindered their potential clinical translation as drug carriers. Hence, in this work, by embedding (doxorubicin (DOX) or methylene blue (MB), etc.) molecules into SiO2 nanoparticles (NPs), self-decomposable drug-embedded NPs were prepared. Importantly, we found that intermediate morphology during decomposition depends on type embedded molecules, (e.g., DOX results mesoporous nanostructures; MB...
We aimed to prospectively evaluate the associations between baseline and changes in high-density C-reactive protein (hs-CRP) incident metabolic syndrome (MetS) China update evidence based on a meta-analysis of cohort studies different populations.Data from Health Retirement Longitudinal Study among adults aged 45 years or older were analyzed. Participants who recruited study 2011-2012 without MetS successfully followed up 2015-2016 included our final analysis. Logistic regressions applied...
Objective: Glucagon-like peptide 1 receptor agonists (GLP-1 RAs) and dipeptidyl peptidase-4 inhibitors (DPP-4i) profoundly affect the gastrointestinal motor system, which may increase incidence of inadequate bowel cleaning symptoms. Hence, this observational study mainly aimed to assess influence GLP-1 RAs liraglutide DPP-4i sitagliptin on preparation in type 2 diabetes (T2DM). Method: This consecutively enrolled T2DM scheduled for a colonoscopy. Participants were prospectively separated...
Abstract Valeriana jatamansi is widely used in Chinese folk medicine and contains iridoids as important active ingredients. The brain-gut axis describes a complex bidirectional system between the central nervous gastrointestinal tract. Herein, we evaluated antidepressant effects of total (TIV) preliminarily investigated gut microbiota on their using chronic, unpredictable mild-stress mouse model. Mice were given 5.7, 11.4, or 22.9 mg/kg TIV for 1 week. Fluoxetine (2.6 mg/kg) served positive...
The benchmark dose (BMD) method has been increasingly used to assess the health risks of cadmium (Cd) in epidemiological studies. aim our study was estimate threshold levels urinary Cd (UCd) using BMD a general population Jiangshan City, Zhejiang Province China. In study, total 934 people (469 men, 465 women) were recruited and morning urine samples collected from all participants. Levels Cd, creatinine, renal dysfunction indicators such as retinol binding protein (RBP), β2-microglobulin...
As a typical human pathogenic fungus, Cryptococcus neoformans is life-threatening invasive fungal pathogen with worldwide distribution causing ∼700,000 deaths annually. Cryptococcosis not just an infection multi-organ involvement, intracellular survival and extracellular multiplication of the fungus also play important roles in pathogenesis C. infections. Because adequate accumulation drugs at target organs cells still difficult to achieve, effective delivery strategy desperately required...
Abstract Background Platinum-based chemotherapy regimens are a mainstay in the management of ovarian cancer (OC), but emergence chemoresistance poses significant clinical challenge. The persistence stem cells (OCSCs) at end primary treatment contributes to disease recurrence. Here, we hypothesized that extracellular matrix protects CSCs during and supports their tumorigenic functions by activating integrin-linked kinase (ILK), key enzyme drug resistance. Methods TCGA datasets OC models were...
This study aimed to clarify the mechanism by which Krüppel-like factor 12 (KLF12) affects progesterone sensitivity in endometrial cancer (EC) through receptor PGR signaling pathway.
The cytotoxicities of the elements current quantum dots (QDs) greatly restrict their applications in biomedical fields.
Fibulin-3 has been reported as a potential biomarker for mesothelioma. However, little is known about the diagnostic efficacies of fibulin-3 asbestos-related diseases (ARDs) in China. This study was to investigate utility asbestos exposure and ARDs. A total 430 subjects were recruited from Southeast China, including healthy individuals, asbestos-exposed (AE) patients with pleural plaques (PP), asbestosis, malignant mesothelioma (MPM). Plasma measured using enzyme-linked immunosorbent assay....
We prospectively examined the association between serum uric acid (SUA) levels and chronic kidney disease (CKD) in China updated evidence through a comprehensive meta-analysis of prospective studies worldwide.Our original analyses were based on data from Health Retirement Longitudinal Study. The primary exposure interest was SUA at baseline, main outcome incident CKD. Logistic regression models used to examine A performed pool our effect estimate those other cohort studies.During 4-year...
Ethno Pharmacological Relevance: Acetylharpagide is a monomeric compound extracted from Ajuga decumbens, widely used for remedying infectious and inflammatory diseases in Southern China. Aim of the Study: The present study designed investigated formulation colon-targeted acetylharpagide tablets according to dual controlled release mechanisms time-delay pH-sensitivity. Materials Methods: core were coated with material systems such as ethyl cellulose suitable channeling agent, followed by...
Emerging evidence suggests that increased perirenal adipose tissue (PAT) may trigger systemic inflammation and oxidative stress, potentially contributing to hyperuricemia (HUA). This study aimed explore the link between PAT HUA risk, potential mediating role of stress. recruited 903 participants with T2DM. Monocyte high-density lipoprotein cholesterol ratio (MHR) was computed assess Perirenal fat thickness (PrFT) measured by unenhanced abdominal CT, indicating mass. Weighted binomial...
Abstract Objectives The main aim of our study is to observe clinical characteristics and effects antihypertensive drugs in different hospitalized populations, further provide evidence explore causes specific markers the aggravation COVID-19 patients with underlying hypertension. Design This was a retrospective cohort focusing on data inpatients admitted at early stage pandemic. Setting A single center conducted Tongji Hospital, Medical College Huazhong university Science Technology (Wuhan,...