A5101932943- Traditional Chinese Medicine Analysis
- Metabolomics and Mass Spectrometry Studies
- Plant Pathogens and Fungal Diseases
- Nanoparticle-Based Drug Delivery
- Nematode management and characterization studies
- Fungal Biology and Applications
- Advanced biosensing and bioanalysis techniques
- Food Quality and Safety Studies
- Antioxidant Activity and Oxidative Stress
- RNA Interference and Gene Delivery
- Microbial Natural Products and Biosynthesis
- Phytochemicals and Antioxidant Activities
- Free Radicals and Antioxidants
- Prenatal Screening and Diagnostics
- Neurological Disease Mechanisms and Treatments
- Hemoglobinopathies and Related Disorders
- Parvovirus B19 Infection Studies
- Fungal Plant Pathogen Control
- Nanoplatforms for cancer theranostics
- Nephrotoxicity and Medicinal Plants
- Medicinal Plant Pharmacodynamics Research
- Natural Compounds in Disease Treatment
- Smart Grid Energy Management
- Plant-Microbe Interactions and Immunity
- Histiocytic Disorders and Treatments
Chinese Academy of Medical Sciences & Peking Union Medical College
2010-2024
Affiliated Hospital of Youjiang Medical University for Nationalities
2023-2024
Weifang Chinese Medicine Hospital
2023
Jiangxi University of Traditional Chinese Medicine
2008-2019
Beijing Academy of Agricultural and Forestry Sciences
2008-2014
Xiamen University
2012-2013
China Agricultural University
2012
Shanxi Medical University
2007
Portable devices with the advantages of rapid, on-site, user-friendly, and cost-effective assessment are widely applied in daily life. However, only a limited number quantitative portable commercially available, among which personal glucose meter (PGM) is most successful example has been used. PGMs can detect blood as unique target. Here we describe novel design that combines glucoamylase-trapped aptamer-cross-linked hydrogel PGM for detection non-glucose targets. Upon target introduction,...
The current study was performed to investigate mitochondrial protection and anti-aging activity of Astragalus polysaccharides (APS) the potential underlying mechanism. Lipid peroxidation liver brain mitochondria induced by Fe(2+)-Vit C in vitro. Thiobarbituric acid (TBA) colorimetry used measure content thiobarbituric reactive substances (TBARS). Mouse permeability transition (PT) calcium overload vitro spectrophotometry it. scavenging activities APS on superoxide anion (O(2) (•-)) hydroxyl...
Because of their ability to greatly enhance the low natural peroxidase activity hemin, G-quadruplex-based DNAzymes have been widely used as an alternative peroxidases for many colorimetric, chemiluminescent, or visual detections metal ions, small molecules, nucleic acids, proteins, and cancer cells. To obtain with better activity, we designed three 81-nt ssDNA libraries containing 25%, 35%, 45% guanine bases, respectively, at 45-nt random regions evolve hemin-binding DNA aptamers using...
Paclitaxel (PTX) is currently the only botanical drug that can control growth of cancer cells. widely used in treatment breast cancer, ovarian uterine non-small cell lung and other cancers.Folate receptor integrin αvβ3 are highly expressed on surface human cells MCF-7. Folic acid arginine-glycine-aspartate (Arg-Gly-Asp, RGD) tripeptide sequence have a high affinity for folate αvβ3, respectively. To enhance effect we constructed RGD peptide dual-targeted (MSNs-NH2-FA-RGD) drug-carrier based...
Introduction: Parkinson's disease (PD) is a common neurodegenerative disorder characterized by the degeneration of dopaminergic neurons in substantia nigra.The precise molecular mechanisms underlying neuronal loss PD remain unknown, and there are currently no effective treatments for PD-associated neurodegeneration.Echinacoside (ECH) known its neuroprotective effects, which include scavenging cellular reactive oxygen species promoting mitochondrial fusion.However, blood-brain barrier (BBB)...
Two rare N-β-D-glucopyranosyl-1H-indole-3-acetic acid conjugates, N-[2-(1-β-D-glucopyranosyl)-1H-indol-3-yl)acetyl]-L-glutamic (1) and N-[2-(1-β-D-glucopyranosyl)-1H-indol-3-yl)acetyl]-L-aspartic (2) were isolated from Ginkgo biloba. The structures elucidated by analyses of HRMS NMR spectroscopic data. In addition, a simplified efficient synthetic route for compounds 1 2 is also disclosed to determine the absolute configurations them. This concise syntheses may facilitate studies biology...
To explore the optimum conditions for extraction of anthocyanins and flavonols from bog bilberry (Vaccinium uliginosum L.) marc on a single-factor experimental basis, response surface methodology was adopted this intensive study. The procedure carried out in Waring blender followed an ultrasonic bath, natural antioxidant carnosic acid added to inhibit oxidation. were as follows: volume fraction ethanol 70%, content 0.02% (the mass sample) acid, liquid-solid ratio 16 mL/g, homogenization time...
Glioblastoma is considered the most fatal malignant brain tumor that starts from central nervous system (CNS), where blood-brain barrier (BBB) remains biggest challenge for active targeting of drugs in tumor. Thereby, we have designed a paclitaxel PTX@ANG/FA-NPs hybrid novel nanodrug delivery can overcome clinical BBB. The structural and morphological characterization confirmed successful synthesis nanomicelles with size range about 160 to 170 nm. overall repressive effect on human...
Abstract Salt-processed Alismatis Rhizoma (SAR) is extensively used in clinical practice and exhibits a more robust urination-promoting effect than (AR). This study employed ultra-performance liquid chromatography–quadrupole-time-of-flight mass spectrometry (UPLC-Q-TOF-MS) pattern analysis to compare the terpenoids between AR SAR. Additionally, this compared effects of SAR on gene expression kidneys rat model edema (syndrome kidney Yin deficiency) by transcriptomics decipher mechanism salt...
The paclitaxel-loaded and folic acid-modified poly(lactic-co-glycolic acid) nano-micelles(PTX@FA-PLGA-NMs) were prepared by the emulsion solvent evaporation method, parameters of nano-micelles optimized with particle size PDI as evaluation indexes. morphology was observed transmission electron microscopy(TEM), stability, drug loading encapsulation efficiency systematically investigated. In vitro experiments performed to study cytotoxic effects nano-micelles, apoptosis, cellular uptake. Under...
In this study, an HPLC method was developed for simultaneous determination of seven alkaloids (cytosine, oxymatrine, N-oxysophocarpine, N-methylcytisine, sophoranol, matrine, and sophocarpine) three flavonoids (trifolirhizin, fermononetin, maackiain) from different samples Sophorae Tonkinensis Radix et Rhizoma. Samples were analyzed on a Welch XtimateTM C₁₈ column (4. 6 mm× 250 mm, 5 μm) eluted with the mobile phase acetonitrile (A) 0.01 mol•L⁻¹ ammonium acetate solution (pH 8.0) (B) in...
To explore a noninvasive method for diagnosis of SEA-thalassemia and to investigate whether the regional factors affect accuracy this method. The involved using public database bioinformatics software construct parental haplotypes proband predicting fetal genotypes relative haplotype dosage. We screened downloaded sequencing data couples who were both carriers from China National Genebank platform, matched format with that reference panel Ubuntu system tools. then used Beagle haplotypes,...
The index weight coefficients were determined by comparing the analytic hierarchy process(AHP), criteria importance through inter-criteria correlation(CRITIC), and AHP-CRITIC mixed weighting method. comprehensive scores of components(echinacoside, salvianolic acid B, paeoniflorin, ointment yield) each group in orthogonal test compared to optimize extraction process Congrong Shujing Granules. results showed that method scientifically optimized process. To be specific, decoction pieces should...
With the continuous exploration of microemulsions as solvents for traditional Chinese medicine extraction, polyoxyethy-lene(35) castor oil(CrEL), a commonly used surfactant, is being utilized by researchers. However, problem detecting residues this surfactant in microemulsion extracts has greatly hampered further development solvents. Based on chemical structures components CrEL and content determination method oil 2020 edition Pharmacopoeia(Vol. Ⅳ), study employed gas chromatography(GC)...