A5057853098- Histone Deacetylase Inhibitors Research
- Ubiquitin and proteasome pathways
- Epigenetics and DNA Methylation
- Protein Degradation and Inhibitors
- Sleep and related disorders
- Cardiovascular Health and Risk Factors
- Cancer-related gene regulation
- Computational Drug Discovery Methods
- Sleep and Work-Related Fatigue
- Environmental Impact and Sustainability
- PARP inhibition in cancer therapy
- Microtubule and mitosis dynamics
- Medical Imaging Techniques and Applications
- Peptidase Inhibition and Analysis
- Climate Change Policy and Economics
- Cancer Mechanisms and Therapy
- Cancer therapeutics and mechanisms
- SARS-CoV-2 and COVID-19 Research
- Artificial Intelligence in Healthcare
- Nuclear Physics and Applications
- Atherosclerosis and Cardiovascular Diseases
- Peroxisome Proliferator-Activated Receptors
- Pancreatic function and diabetes
- 14-3-3 protein interactions
- RNA modifications and cancer
China Pharmaceutical University
2014-2025
Xinyang College of Agriculture and Forestry
2025
Inner Mongolia University
2023-2024
Zhengzhou University
2020-2024
Shenzhen Bay Laboratory
2024
Fourth People’s Hospital of Jinan
2024
Chinese PLA General Hospital
2017-2024
Bengbu Medical College
2024
Air Force Medical University
2024
Xijing Hospital
2024
Abstract With the development of data mining, machine learning offers opportunities to improve discrimination by analyzing complex interactions among massive variables. To test ability algorithms for predicting risk type 2 diabetes mellitus (T2DM) in a rural Chinese population, we focus on total 36,652 eligible participants from Henan Rural Cohort Study. Risk assessment models T2DM were developed using six algorithms, including logistic regression (LR), classification and tree (CART),...
The application of peptide drugs in cancer therapy is impeded by their poor biostability and weak cell permeability. Therefore, it imperative to find biostable cell-permeable for treatment. Here, we identified a potent, selective, biostable, cyclic d-peptide, NKTP-3, that targets NRP1 KRASG12D using structure-based virtual screening. NKTP-3 exhibited strong cellular uptake ability. Importantly, significantly inhibited the growth A427 cells with mutation. Moreover, showed antitumor activity...
Multitarget medications represent an appealing therapy against the disease with multifactorial abnormalities─cancer. Therefore, simultaneously targeting son of sevenless 1 (SOS1) and epidermal growth factor receptor (EGFR), two aberrantly expressed proteins crucial for oncogenesis progression prostate cancer, may achieve active antitumor effects. Here, we discovered dual SOS1/EGFR-targeting compounds via pharmacophore-based docking screening. The most prominent compound SE-9 exhibited...
The human microbiome plays an important role in autoimmune diseases. However, there is limited knowledge regarding the microbiota individuals with primary Sjögren's syndrome (pSS). Here, we perform 16S ribosomal RNA gene sequencing of fecal, oral, and vaginal samples from a cohort 133 pSS, 56 non-pSS, 40 healthy control (HC) individuals. Dysbiosis gut, evident patients oral demonstrate greatest extent microbial variation. Multiple key indicator bacteria clinical characteristics are...
Social support has been identified as a key factor influencing adolescents' engagement in physical activities. However, the relationship between middle school girls' activity levels and actual social they receive remains unclear. This study aims to explore mechanisms that promote increased participation among girls. A survey was conducted with 1,371 girls from 16 regions cities China. The questionnaire included Physical Activity Questionnaire (PAQ), Support Exercise Survey, Rank Scale,...
HoxB9, as a Hox family member, is known to play important roles in embryonic development. Recent studies showed that HoxB9 engaged cancer progression. However, the role of Hoxb9 lung adenocarcinoma unknown. The purpose this study investigate expression and prognostic value patients with adenocarcinoma.The localization were examined by immunohistochemistry. correlation between levels patient survival was assessed Kaplan-Meier analysis. epithelial-mesenchymal transition (EMT) markers migratory...
DNA methylation, the most intensively studied epigenetic modification, plays an important role in understanding molecular basis of diseases. Furthermore, epigenome-wide association study (EWAS) provides a systematic approach to identify variants underlying common diseases/phenotypes. However, there is no comprehensive database archive results EWASs. To fill this gap, we developed EWASdb, which part 'The EWAS Project', store methylation from In its current version (v 1.0, up July 2018),...
Abstract Polo‐like kinase 1 (PLK1) and polo‐like 4 (PLK4) are closely associated with the progression of several cancers, their bispecific inhibitors can kill tumor cells effectively. Herein, a redox‐responsive supramolecular nanomedicine based on self‐assembly cyclic peptide, termed as C‐1, targeting both PLK1 PLK4 potent anticancer agent is reported. C‐1 peptide in response to reducing agents such glutathione (GSH), which constructed by combined approach pharmacophore modeling, molecular...
Carbon neutrality has increasingly become a crucial agenda within global climate governance. Meanwhile, recent observations show that the governance architecture for carbon is transforming to polycentricity. However, there still lack of systematic investigation on under polycentric approach. Against this background, study attempts investigate emergence and structure governance, figure out what extent evolving system can contribute change towards neutrality. The results efforts made by actors...
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To investigate the clinical value of MRI modified water-lipid separation technique (mDIXON-Quant) in terms T2* values and fat fraction (FF) for evaluating degree cervical intervertebral disc degeneration. A total 118 patients who underwent routine vertebra mDIXON-Quant examination Fuyang People's Hospital from March 2019 to January 2024 were collected. The C2/3 C6/7 discs FF upper lower vertebral bodies measured. Cervical degeneration was graded according Pfirrmann criteria. different...
Concurrent inhibition of bromodomain-containing protein 4 (BRD4) and signal transductor activator transcription 3 (STAT3) could potentially be an effective strategy against renal cell carcinoma (RCC). Here, we successfully identified five dual-targeted BRD4/STAT3 inhibitors (BSTs 1-5) using a combinatorial screening protocol. Particularly, BST-4 was the most potent inhibitor simultaneously targeting BRD4 (IC50 = 2.45 ± 0.11 nM) STAT3 8.07 0.51 nM). MD simulation indicated that stably bound...
Acute myeloid leukemia (AML) is a highly aggressive hematological malignancy with significant unmet clinical need for new therapeutic agents. Lysine-specific demethylase 1 (LSD1), key regulator of stem cell self-renewal, has emerged as promising epigenetic target AML treatment. Herein, we employed an innovative multi-step integrated screening protocol, encompassing pharmacophore modeling, docking screening, molecular dynamics simulation, and biological evaluation, to identify novel LSD1...
PLK1 is essential for cell cycle regulation and proliferation, its elevated expression in prostate cancer associated with high tumour grade. Therefore, inhibition considered a promising strategy the treatment of cancer. Here, we identified five compounds (Hits 1-5) targeting kinase domain (KD) using combined virtual screening approach. Hits 1-5 all had picomolar (pM) inhibitory potency against PLK1. Notably, Hit-4 showed strongest activity (IC50 = 22.61 ± 1.12 pM) displayed selectivity...
Nucleic acid sequences carry the most fundamental information about life, and gene detection plays a crucial role in studying applying function. Here, we present novel probe design that utilizes cleavage capillary electrophoresis for detection, termed ProbeCE which detects genes by measuring relative fluorescence signal intensity. Through evaluation of probes with varying lengths modifications, is believed to support simultaneous hundreds genes. Additionally, assessment low-concentration...
Postpartum hypoxia is a significant concern among clinicians due to its association with fatal diseases such as amniotic fluid embolism. This study analyzed the clinical characteristics of patients different etiologies postpartum hypoxia. Ninety-two cases hypoxia, defined oxygen saturation (SpO2) < 95% within 48 h without supplemental inhalation, and 100 normal gravidas were enrolled. All underwent 24 vital sign monitoring relevant examinations, including hematological tests, chest computed...
Abstract Supramolecular nanomedicines based on self‐assembly of D‐peptides have been great interest as potential candidates for cancer therapy. Neuropilin‐1 (NRP1) and mouse double minute 2 (MDM2) considered the anticancer targets because their overexpression in cancers. However, NRP1/MDM2‐targeted D‐peptide supramolecular remain unreported. Here, a potent nanomedicine targeting NRP1 MDM2, termed NMTP‐5, is identified by using structure‐based virtual screening techniques. NMTP‐5 exhibits...
Dual inhibition of tubulin and poly(ADP-ribose) polymerase-1 (PARP-1) may become an attractive approach for cancer therapy. Here, we discover a dual tubulin/PARP-1 inhibitor (termed as TP-3) using structure-based virtual screening. TP-3 shows strong inhibitory effects on both PARP-1. Cellular assays reveal that superior antiproliferative activities against human cells, including breast, liver, ovarian, cervical cancers. Further studies indicate plays antitumor role through multiple...