A5028880252- Acute Myeloid Leukemia Research
- Chronic Myeloid Leukemia Treatments
- Pituitary Gland Disorders and Treatments
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- CAR-T cell therapy research
- Multiple Myeloma Research and Treatments
- Glioma Diagnosis and Treatment
- Oral and Maxillofacial Pathology
- Pharmacogenetics and Drug Metabolism
- Telomeres, Telomerase, and Senescence
- Reproductive Biology and Fertility
- Adrenal and Paraganglionic Tumors
- Sperm and Testicular Function
- Prostate Cancer Treatment and Research
- Effects of Radiation Exposure
- Neurological Complications and Syndromes
- Research in Cotton Cultivation
- Adenosine and Purinergic Signaling
- Cancer, Hypoxia, and Metabolism
- Tissue Engineering and Regenerative Medicine
- Renal Transplantation Outcomes and Treatments
- Bioenergy crop production and management
- Salivary Gland Tumors Diagnosis and Treatment
- Insect Resistance and Genetics
- Glutathione Transferases and Polymorphisms
Xuzhou Medical College
2023-2025
Second People’s Hospital of Huai’an
2023-2025
Xi'an Jiaotong University
2025
Xian Central Hospital
2024-2025
Memorial Sloan Kettering Cancer Center
2024
Wuhan University
2023
Henan University of Science and Technology
2009
Northwest A&F University
2007
University of Wisconsin System
1993
Normal cells require adhesion to extracellular matrix for survival. Cell detachment causes a drastic increase in reactive oxygen species (ROS) that promotes anoikis. In the present study, we observed upon from matrix, human mammary epithelial strongly upregulate manganese superoxide dismutase (MnSOD, or SOD2), principal mitochondrial antioxidant enzyme detoxifies ROS through dismutation of superoxide. Induction MnSOD by cell is dependent on NFκB transcription factor. Detachment potently...
Abstract Pituitary neuroendocrine tumors (PitNETs) exhibiting aggressive, treatment-refractory behavior are the rare subset that progress after surgery, conventional medical therapies, and an initial course of radiation characterized by unrelenting growth and/or metastatic dissemination. Two groups patients with PitNETs were sequenced: a prospective group ( n = 66) who consented to sequencing prior surgery retrospective 26) comprised aggressive/higher risk PitNETs. A higher mutational burden...
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Acute myeloid leukemia (AML) is a highly aggressive hematological malignancy with significant unmet clinical need for new therapeutic agents. Lysine-specific demethylase 1 (LSD1), key regulator of stem cell self-renewal, has emerged as promising epigenetic target AML treatment. Herein, we employed an innovative multi-step integrated screening protocol, encompassing pharmacophore modeling, docking screening, molecular dynamics simulation, and biological evaluation, to identify novel LSD1...
We report here that (-)-gossypol significantly inhibits the proliferation of stromal cells derived from human breast adipose tissues (human cells) in a dose-dependent manner. The mechanisms involved anti-proliferative action on were also investigated. (-)-Gossypol stimulated transforming growth factor (TGFbeta1) secretion after 24 h, and RNase protection assay showed TGFbeta1 mRNA levels increased as well. observed inhibited When co-incubated with 5 microM 50 microgram/ml...
Abstract Background: Pertuzumab is a recombinant humanized monoclonal antibody targeting the extracellular dimerization domain II of HER2. On September 30, 2013, FDA have granted accelerated approval pertuzumab regimen for neoadjuvant treatment patients (pts) with high-risk, HER2-positive early stage breast cancer. TQB2440 (Perjeta®, Roche) biosimilar. This study aimed to compare efficacy and safety reference combined trastuzumab docetaxel in pts or locally advanced Methods: In this...
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)
Although rice has many pests, brown planthopper (BPH) in particular is known to cause substantial damage. The pyramiding application of BPH-resistance genes BPH14 and BPH15 proven effective enhancing defense against BPH. However, the molecular mechanisms underlying / -conferred resistance remain unexplained. In this investigation, we analyzed transcriptomes near isogenic lines (NILs) containing either (B14), (B15), or BPH14/BPH15 (B1415), as well their recurrent parent (RP) ‘Wushansimiao’....
The aim of this study was to determine whether the human telomerase catalytic reverse transcriptase (hTERT) could express in bovine mammary epithelial cells (BMEC) and examine effects hTERT on life span growth characteristics BMEC.We tested one hTERT-transferred cell lines (HBM3), Western Blotting Assay showed that HBM3 had activity, moreover, a prolonged demonstrated extensive proliferative capacity as evidenced by their ability continuously grow even when seeded at low dilutions.In...