A5103219341- Cancer Immunotherapy and Biomarkers
- Cell Adhesion Molecules Research
- Immunotherapy and Immune Responses
- CAR-T cell therapy research
- 14-3-3 protein interactions
- Kruppel-like factors research
- vaccines and immunoinformatics approaches
- Caveolin-1 and cellular processes
- Inflammation biomarkers and pathways
- Epigenetics and DNA Methylation
- Bone Metabolism and Diseases
- Monoclonal and Polyclonal Antibodies Research
- Apelin-related biomedical research
- Ubiquitin and proteasome pathways
- Reproductive Biology and Fertility
- Cancer Cells and Metastasis
- Immune Cell Function and Interaction
- Renal and related cancers
CRUK Lung Cancer Centre of Excellence
2023-2025
University College London
2023-2025
London Cancer
2025
Indiana University – Purdue University Indianapolis
2024
Indiana University School of Medicine
2024
Indiana University
2024
University of Indianapolis
2024
University School
2024
Cardiff University
2023
The T cells of the immune system can target tumors and clear solid cancers following tumor-infiltrating lymphocyte (TIL) therapy. We used combinatorial peptide libraries a proteomic database to reveal antigen specificities persistent cancer-specific cell receptors (TCRs) successful TIL therapy for stage IV malignant melanoma. Remarkably, individual TCRs could multiple different tumor types via HLA A∗02:01-restricted epitopes EAAGIGILTV, LLLGIGILVL, NLSALGIFST from Melan A, BST2, IMP2,...
Abstract Neoantigen vaccines are under investigation for various cancers, including epidermal growth factor receptor ( EGFR )-driven lung cancers 1,2 . We tracked the phylogenetic history of an mutant cancer treated with erlotinib, osimertinib, radiotherapy and a personalized neopeptide vaccine (NPV) targeting ten somatic mutations, exon 19 deletion (ex19del). The ex19del mutation was clonal, but is likely to have appeared after whole-genome doubling (WGD) event. Following osimertinib NPV...
Protamines (PRM1 and PRM2) are small, arginine-rich, nuclear proteins that replace histones in the final stages of spermiogenesis, ensuring chromatin compaction remodeling. Defects protamination lead to increased DNA fragmentation reduced male fertility. Since efficient sperm production requires translocation protamines from cytoplasm nucleus, we investigated whether SPAG17, a protein crucial for intracellular trafficking during participates protamine transport. Initially, assessed...
Abstract Background Platinum-based chemotherapy regimens are a mainstay in the management of ovarian cancer (OC), but emergence chemoresistance poses significant clinical challenge. The persistence stem cells (OCSCs) at end primary treatment contributes to disease recurrence. Here, we hypothesized that extracellular matrix protects CSCs during and supports their tumorigenic functions by activating integrin-linked kinase (ILK), key enzyme drug resistance. Methods TCGA datasets OC models were...
Abstract Background: Effective treatment of ovarian cancer (OC) is greatly impacted by advanced, late-stage diagnosis which usually presents with intra-peritoneal metastases, chemoresistance and high recurrence. The development metastases correlated the formation multicellular spheroids disseminated in peritoneal fluid. Spheroid promoted a change cell adhesion properties, enhanced secretion extracellular matrix (ECM) components that stiffen tumor stroma promote aberrant activation oncogenic...
<title>Abstract</title> Background Platinum-based chemotherapy regimens are a mainstay in the management of ovarian cancer (OC), but emergence chemoresistance poses significant clinical challenge. The persistence stem cells (OCSCs) at end primary treatment contributes to disease recurrence. Here, we hypothesized that extracellular matrix protects CSCs during and supports their tumorigenic functions by activating integrin-linked kinase (ILK), key enzyme drug resistance. Methods TCGA datasets...
Abstract The R47H variant of the triggering receptor expressed on myeloid cells 2 (TREM2) is a risk factor for Alzheimer’s disease in humans and leads to lower bone mass accrual female but not male 12-mo-old mice. To determine whether, as with aging, gonadectomy results sex-specific musculoskeletal effects, gonad removal or SHAM surgery was performed 4-mo-old TREM2R47H/+ mice WT littermates (n = 10-12/group), sexes analyzed separately. Body weight males, higher females after gonadectomy,...
<h3>Background</h3> Advanced lung cancer kills 90% of patients within a decade, underscoring an urgent need for improved early detection and prevention technologies. T cell responses are initiated dysregulated during carcinogenesis <i>in vivo</i>, providing potential basis immune-focused interception. Here we examined cross-tissue dynamics human murine squamous to assess their utility in immune-interception. <h3>Methods</h3> Over decade ago clinical autofluorescence bronchoscopy surveillance...
<h3>Background</h3> Adoptive transfer of ex-vivo expanded tumor-infiltrating lymphocytes (TIL) has shown promise in the clinic. However, non-specific expansion TIL and lack understanding active component resulted poor correlation between clinical response dose as well resistance mechanisms. The VELOS<sup>TM</sup> manufacturing process generates a precision personalized treatment modality by targeting clonal neoantigens with incorporation an antigen-specific step to enrich product for these...