A5062105716- Bone health and osteoporosis research
- Bone Metabolism and Diseases
- Bone health and treatments
- Connective tissue disorders research
- Parathyroid Disorders and Treatments
- Vitamin K Research Studies
- Adipose Tissue and Metabolism
- Bone fractures and treatments
- Anodic Oxide Films and Nanostructures
- Metabolism, Diabetes, and Cancer
- Advanced Image and Video Retrieval Techniques
- Diabetes and associated disorders
- Adipokines, Inflammation, and Metabolic Diseases
- Fluorine in Organic Chemistry
- Estrogen and related hormone effects
- Bone Tissue Engineering Materials
- Pancreatic function and diabetes
- Metal and Thin Film Mechanics
- Mobile Crowdsensing and Crowdsourcing
- Multimodal Machine Learning Applications
- Organic Chemistry Cycloaddition Reactions
- Hydrogen embrittlement and corrosion behaviors in metals
- Concrete Corrosion and Durability
- Hip and Femur Fractures
- Titanium Alloys Microstructure and Properties
University of Indianapolis
2020-2025
Indiana University – Purdue University Indianapolis
2020-2025
Indiana University
2024
Lake Erie College of Osteopathic Medicine
2024
Kohler (United States)
2023
Purdue University West Lafayette
2020-2021
Virginia Tech
2017-2019
Airbus (United Kingdom)
1983
Ministry of Defence
1983
Expert investigators bring advanced skills and deep experience to analyze visual evidence, but they face limits on their time attention. In contrast, crowds of novices can be highly scalable parallelizable, lack expertise. this paper, we introduce the concept shared representations for crowd--augmented expert work, focusing complex sensemaking task image geolocation performed by professional journalists human rights investigators. We built GroundTruth, an online system that uses three...
As international incidence of diabetes and diabetes-driven comorbidities such as chronic kidney disease (CKD) continue to climb, interventions are needed that address the high-risk skeletal fragility what is a complex state. Romosozumab (Romo) an FDA-approved sclerostin inhibitor has been shown increase bone mineral density decrease fracture rates in osteoporotic patients with mild severe CKD, but its effect on diabetes-weakened unknown. We aimed test Romo's performance model combined CKD....
ABSTRACT Micro‐computed tomography is a critical assessment tool for bone‐related preclinical research, especially in murine models. To expedite the scanning process, researchers often image multiple bones simultaneously; however, it unknown if this impacts scan quality and alters ability to detect differences between experimental groups. The purpose of study was assess effect multibone on detecting disease‐induced changes bone microarchitecture mineral density by group two models with known...
Methodology is described for the synthesis of C6 derivatives raloxifene, a prescribed drug treatment and prevention osteoporosis. Studies have explored incorporation electron-withdrawing substituents at benzothiophene core. Efficient processes are also examined to introduce hydrogen bond donor acceptor functionality. Raloxifene evaluated with in vitro testing determine estrogen receptor (ER) binding affinity gene expression MC3T3 cells.
Osteogenesis imperfecta (OI) is a hereditary bone disease where gene mutations affect Type I collagen formation resulting in osteopenia and increased fracture risk. There are several established mouse models of OI, but some severe result spontaneous fractures or early animal death. The Amish Col1a2 G610C/+ (G610C) model newer, moderate OI that currently being used variety intervention studies, with differing background strains, sexes, ages, endpoints. This study comprehensive mechanical...
Skeletal fragility leading to fracture is an American public health crisis resulting in 1.5 million fractures each year and $18 billion direct care costs. The ability understand the mechanisms underlying bone disease response treatment not only desired, but critical. Mechanical testing of serves as a valuable technique for understanding quantifying bone's susceptibility fracture. While this method appears simple perform, inappropriate inaccurate conclusions may be reached if governing...
Geolocation, the process of identifying precise location in world where a photo or video was taken, is central to many types investigative work, from debunking fake news posted on social media locating terrorist training camps. Professional geolocation often manual, time-consuming that involves searching large areas satellite imagery for potential matches. In this paper, we explore how crowdsourcing can be used support expert image geolocation. We adapt an diagramming technique overcome...
Summary Understanding of surface evolution is important in applications that require engineering prescribed structures. Novel crystalized formations have been observed on titanium specimens etched with sulfuric acid as part an ongoing implantology research. Crystal resembling rosettes were discovered via scanning electron microcopy near the edges several commercially pure by immersion 18M (98%) at 60° C for 30 minutes to 1 hour. These crystallized composed numerous thin sheets (in...
Abstract In the USA, as many 20 % of recruits sustain stress fractures during basic training. addition, approximately one-third female develop Fe deficiency upon completion is a cofactor in bone collagen formation and vitamin D activation, thus we hypothesised may be contributing to altered microarchitecture mechanics 12-weeks increased mechanical loading. Three-week old Sprague Dawley rats were assigned one four groups: Fe-adequate sedentary, Fe-deficient exercise exercise. Exercise...
The Coronary Artery Risk Detection in Appalachian Communities (CARDIAC) project surveyed cardiometabolic risk factors to identify for adult heart disease through a school-based program.(1) This current investigation determined follow-up status of children who were identified with elevated LDL-C level that suggests diagnosis Familial Hypercholesterolemia (FH). We hypothesize deficient persons probable FH from screening WV fifth grade classes. Other markers suggested ongoing health care many...
Abstract The R47H variant of the triggering receptor expressed on myeloid cells 2 (TREM2) is a risk factor for Alzheimer’s disease in humans and leads to lower bone mass accrual female but not male 12-mo-old mice. To determine whether, as with aging, gonadectomy results sex-specific musculoskeletal effects, gonad removal or SHAM surgery was performed 4-mo-old TREM2R47H/+ mice WT littermates (n = 10-12/group), sexes analyzed separately. Body weight males, higher females after gonadectomy,...
Methodology is described for synthesis of C6 derivatives raloxifene, a prescribed drug the treatment and prevention osteoporosis. Studies explore incorporation electron-withdrawing substituents at benzothiophene core. Efficient processes are also examined to introduce hydrogen bond donor acceptor functionality. Raloxifene evaluated with in vitro testing determine estrogen receptor (ER) binding affinity gene expression MC3T3 cells.
Many types of investigative work involve verifying the legitimacy visual evidence by identifying precise geographic location where a photo or video was taken. Professional geolocation is often manual, time-consuming process that can searching large areas satellite imagery for potential matches. In this paper, we explore how crowdsourcing be used to support expert image geolocation. We adapt an diagramming technique overcome spatial reasoning limitations novice crowds so they expert's search....
Patients with chronic kidney disease (CKD) have high risk of fracture in part due to cortical bone deterioration. The goal this study was assess the impact two different bisphosphonates and dosing regimens on microstructure (porosity, thickness, area) mechanical properties animal models CKD. In experiment 1, Male Cy/+ rats were treated either a single dose or ten fractionated doses zoledronate at 18 weeks age. Fractionated animals received 1/10th given weekly for 10 weeks, endpoint 28 2,...
Problem: West Virginia perennially leads the US in child obesity and adult heart disease. We had screened over 100,000 school children for cardiometabolic risk factors (CMRF) Coronary Artery Risk Detection Appalachian Communities (CARDIAC) program 20 years until 2017 economic downturn. 60,000 lipid panels. WVU Health System includes encounters with 200,000 WV children. hypothesize that CMRF screening has decreased without statewide CARDIAC Program. Methods: queried our instance of Epic...