A5062472653- Diabetes and associated disorders
- Diabetes Management and Research
- Pancreatic function and diabetes
- Bone Metabolism and Diseases
- Metabolism, Diabetes, and Cancer
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Bone health and treatments
- Neurobiology and Insect Physiology Research
- Intramuscular injections and effects
- Diabetes Treatment and Management
- Agricultural and Food Sciences
- Genetics and Physical Performance
- Genetic Associations and Epidemiology
- Circadian rhythm and melatonin
- Anesthesia and Sedative Agents
- Inflammation biomarkers and pathways
- Muscle Physiology and Disorders
- Apelin-related biomedical research
- Cancer, Stress, Anesthesia, and Immune Response
- Blood disorders and treatments
- Heavy Metals in Plants
- Connexins and lens biology
- Radioactivity and Radon Measurements
- Stress Responses and Cortisol
- Bone health and osteoporosis research
Consejo Nacional de Investigaciones Científicas y Técnicas
1982-2024
Indiana University School of Medicine
2023-2024
Indiana University – Purdue University Indianapolis
2023-2024
National University of Rosario
2023-2024
Indiana University
2024
Centro Científico Tecnológico - San Juan
2024
University of California, San Francisco
1985-2007
University of Michigan
1985
University of Buenos Aires
1982
Patients with non-insulin-dependent diabetes mellitus (NIDDM) who have chronic hyperglycemia lose acute incremental insulin responses to glucose but are able briskly respond other β-cell secretagogues. To investigate whether this is a defect specific for or represents more general phenomenon, we measured the intravenous tolbutamide in 10 obese patients NIDDM both before and during sulfonylurea therapy tolazamide. Comparable glycemia was achieved oral dextrose 2 h testing. assess...
Yerba mate (YM, Ilex paraguariensis) consumption beneficially affects the bones. However, whether YM components exert their effect on bone cells directly remains elusive. We evaluated how main affect osteoblastic (MC3T3-E1) and osteocytic (MLO-Y4) in vitro when administered separately or an aqueous extract. MC3T3-E1 MLO-Y4 were exposed to three different experimental conditions: (1) Caffeine, chlorogenic acid, combinations; (2) rutin, (3) Aqueous All polyphenol caffeine concentrations as...
Abstract Vertebrate sexual dimorphism is ascribed to the presence of testes or ovaries, and, hence, secretion gonad-specific hormones. However, mounting evidence indicates that sex differences in tissues and organs also stem from chromosomes (XX XY). To tease out contribution gonads musculoskeletal system, we used Four-Core Genotypes (FCG) mouse model, which Sry gene, dictates testis formation, was either deleted Y chromosome, resulting XY mice with ovaries (XY-SryO), overexpressed XX mice,...
Recurrent episodes of spontaneous hypoglycemia developed in a 30-yr-old woman who had received brief course insulin therapy 10 yr previously. She denied surreptitious administration, and the autoimmune syndrome was considered. Her levels could not be reliably measured because presence circulating antiinsulin antibodies, which interfere with standard RIA techniques. Reverse phase high performance liquid chromatographic analysis serum obtained during hypoglycemic episode revealed mixture beef...
Abstract The R47H variant of the triggering receptor expressed on myeloid cells 2 (TREM2) is a risk factor for Alzheimer’s disease in humans and leads to lower bone mass accrual female but not male 12-mo-old mice. To determine whether, as with aging, gonadectomy results sex-specific musculoskeletal effects, gonad removal or SHAM surgery was performed 4-mo-old TREM2R47H/+ mice WT littermates (n = 10-12/group), sexes analyzed separately. Body weight males, higher females after gonadectomy,...
The presence of gap junction intercellular communication structures in bone cells has been known since the early 1970s, further confirmed by Doty and Marotti at structural level 1980-1990s. Work Civitelli, Donahue, others showed expression Cx43 mRNA protein levels all cell types: osteoclasts (bone resorbing cells), osteoblasts forming osteocytes (mature embedded matrix that regulate function both osteoblasts). While Cx45, Cx46, Cx37 were also shown to be expressed cells, most studies have...