A5003063631- Bone health and osteoporosis research
- Bone Metabolism and Diseases
- Bone health and treatments
- Parathyroid Disorders and Treatments
- Bone fractures and treatments
- Connective tissue disorders research
- Orthopaedic implants and arthroplasty
- Vitamin D Research Studies
- Collagen: Extraction and Characterization
- Bone Tissue Engineering Materials
- Down syndrome and intellectual disability research
- Genetics and Neurodevelopmental Disorders
- Bone and Dental Protein Studies
- Orthopedic Infections and Treatments
- Adipose Tissue and Metabolism
- Vitamin K Research Studies
- Genetics and Physical Performance
- Total Knee Arthroplasty Outcomes
- Medical Imaging Techniques and Applications
- Osteoarthritis Treatment and Mechanisms
- Elasticity and Material Modeling
- Cellular Mechanics and Interactions
- Trace Elements in Health
- Heat shock proteins research
- Estrogen and related hormone effects
Indiana University – Purdue University Indianapolis
2016-2025
University of Indianapolis
2016-2025
Purdue University West Lafayette
1968-2025
Richard L. Roudebush VA Medical Center
2020-2025
Indiana University School of Medicine
2013-2024
Atlanta VA Health Care System
2018-2024
Weldon City Schools
2024
Indiana Hemophilia and Thrombosis Center
2020-2023
Emory University
2018-2022
American Society For Engineering Education
2020
The energetics, stoichiometry, and structure of poly(amidoamine) (PAMAM) dendrimer−phospholipid interactions were measured with isothermal titration calorimetry (ITC), transmission electron microscopy (TEM), atomic force (AFM), dynamic light scattering (DLS), molecular dynamics (MD) simulations. Dendrimers sixth-generation smaller interacted the lipids at an average stoichiometry enthalpy proportional to number primary amines per dendrimers (4.5 ± 0.1 lipids/primary amine 6.3 0.3 kJ/mol...
Water constitutes roughly a quarter of the cortical bone by volume yet can greatly influence mechanical properties and tissue quality. There is growing appreciation for how water dynamically change due to age, disease, treatment. A key emerging area related lies in differentiating role its four different compartments, including free/pore water, loosely bound at collagen/mineral interfaces, tightly within collagen triple helices, structural mineral. This review summarizes our current...
Tissue mechanical properties reflect extracellular matrix composition and organization, as such, their changes can be a signature of disease. Examples such diseases include intervertebral disk degeneration, cancer, atherosclerosis, osteoarthritis, osteoporosis, tooth decay. Here we introduce the tissue diagnostic instrument (TDI), device designed to probe normal diseased soft hard tissues not only in laboratory but also patients. The TDI distinguish between nucleus annulus spinal disks,...
This study demonstrates that collagen, the most abundant protein in animals, exists as a distribution of nanoscale morphologies teeth, bones, and tendons. fundamental characteristic Type I collagen has not previously been reported provides new understanding architecture this ubiquitous important biological nanomaterial. Dentin, bone, tendon tissue samples were chosen for their differences cellular origin function, well to compare mineralized tissues with lacks mineral normal physiological...
Strain-induced adaption of bone has been well-studied in an axial loading model the mouse tibia. However, most outcomes these studies are restricted to changes architecture and do not explore mechanical implications those changes. Herein, we studied both morphological adaptions three strain levels using a targeted tibial model. We hypothesized that would increase improve cortical properties dose-dependent fashion. The right tibiae female C57BL/6 mice (8 week old) were compressively loaded...
This article details a quantitative method to measure the D-periodic spacing of type I collagen fibrils using atomic force microscopy coupled with analysis two-dimensional fast fourier transform approach. Instrument calibration, data sampling and are discussed comparisons complementary methods electron X-ray scattering made. Examples application this new approach morphology in disease models estrogen depletion osteogenesis imperfecta (OI) provided. We demonstrate that it is D-spacing...
Secondary hyperparathyroidism is associated with osteoporosis and fractures. Etelcalcetide an intravenous calcimimetic for the control of in patients on hemodialysis. Effects etelcalcetide skeleton are unknown.
Down syndrome (DS) is caused by triplication of human chromosome 21 (Hsa21), resulting in skeletal insufficiency and altered postnatal bone development individuals with DS. DS mouse models have shown similar deficits to humans DS, mimicking differences between ages, sexes, compartments. The historic model, Ts65Dn, has provided much the mechanistic insight behind these DS-related deficits, but there are concerns over its construct validity. Ts65Dn mice an additional 60 trisomic genes that...
The mechanical properties of bone are dictated by its amount, distribution and 'quality'. composition the mineral matrix phases is integral to defining 'bone quality'. Exercise can potentially increase resistance fracture, yet effects exercise on skeletal fragility, how alterations in fragility modulated bone, unknown. In this investigation, size, composition, damage bones from mice various ages, background strains genetic makeup were assessed, as a means testing hypothesis that loading...
Chronic kidney disease (CKD), which leads tocortical bone loss and increasedporosity,increases therisk of fracture. Animal models have confirmed that these changes compromise whole mechanical properties. Estimates from testing suggest material properties are negatively affected, though tissue-level assessmentshavenot been conducted. Therefore, the goal present study was to examine in cortical at different length scales using a rat model with theprogressive development CKD. At 30 weeks age...