A5079819191- Cancer Cells and Metastasis
- Kruppel-like factors research
- Glycosylation and Glycoproteins Research
- Cancer-related Molecular Pathways
- 14-3-3 protein interactions
- Hedgehog Signaling Pathway Studies
- Chronic Myeloid Leukemia Treatments
- Renal and related cancers
- Epigenetics and DNA Methylation
- Caveolin-1 and cellular processes
- Pluripotent Stem Cells Research
- HER2/EGFR in Cancer Research
- Cancer-related molecular mechanisms research
- CRISPR and Genetic Engineering
- Cell Adhesion Molecules Research
- Ovarian cancer diagnosis and treatment
- Angiogenesis and VEGF in Cancer
- Cancer, Hypoxia, and Metabolism
- Renal Diseases and Glomerulopathies
- Phagocytosis and Immune Regulation
- FOXO transcription factor regulation
- Ubiquitin and proteasome pathways
- Chemotherapy-induced cardiotoxicity and mitigation
- Microtubule and mitosis dynamics
- Nuclear Structure and Function
Indiana University School of Medicine
2024
Indiana University
2024
University School
2024
Indiana University – Purdue University Indianapolis
2024
Rogers (United States)
2024
Cancer Institute (WIA)
2015-2021
Abstract Anaplastic thyroid carcinoma (ATC) is one of the most lethal malignancies having no effective treatment. Exportin-1 (XPO1) key mediator nuclear export many tumor suppressor proteins and overexpressed in human cancers. In this study, we examined therapeutic potential selinexor (XPO1 inhibitor) against ATC cells both vitro vivo . Here, showed that XPO1 robustly expressed primary samples cell lines. Silencing by either shRNA or significantly reduced cellular growth induced cycle...
Abstract Background Platinum-based chemotherapy regimens are a mainstay in the management of ovarian cancer (OC), but emergence chemoresistance poses significant clinical challenge. The persistence stem cells (OCSCs) at end primary treatment contributes to disease recurrence. Here, we hypothesized that extracellular matrix protects CSCs during and supports their tumorigenic functions by activating integrin-linked kinase (ILK), key enzyme drug resistance. Methods TCGA datasets OC models were...
BACKGROUND: There has been variability between laboratories in the identification of cancer stem cells (CSCs) markers for epithelial ovarian (EOC). We have evaluated three new surface EOC to identify CSCs precisely. METHODS: Three putative specific CD9, C D24 and EPHA1 identified by a bioinformatics approach were normal ovary, fallopian tube tumours. RESULTS: The expression CD9 alone was observed epithelium whereas CD24 not expressed (n= 5). all tumours (N= 101) while 89 71 tumours,...
ErbB2 is an important receptor tyrosine kinase and a member of the ErbB family. Although it does not have specific ligand, transmits signals downstream by heterodimerization with other receptors in It plays major role variety cellular responses like proliferation, differentiation, adhesion. amplified at DNA level breast cancer (20%-30%) gastric (10%-20%), trastuzumab effective as therapeutic antibody. This review critical analysis currently published data on signaling pathways interacting...
Transcription factors NANOG, OCT4, SOX2, and NESTIN are expressed in both human embryonic stem cells (hESCs) cancer they play a crucial role maintaining characteristics of stemness such as self-renewal pluripotency. This article evaluates the expression variants main cell-specific transcription NANOG OCT4 critically accurately with specific primers designed for identifying most important that maintain stemness. We have examined four along processed pseudogene seven teratocarcinoma cell lines...
Cardiotoxicity is the most serious side effect of anthracyclines (doxorubicin, daunorubicin or epirubicin). The incidence anthracycline induced late cardiac toxicity (AIC) that overt clinically 3–5% in Indian population. Polymorphism intron 32 (deletion 25 bp) MYBPC3 has been shown to be present exclusively Asians and more so South India (3–8%). frequency polymorphism significantly higher (13%) patients with cardiomyopathy India. Fifteen were identified have dysfunction following treatment...
Abstract Cancer Stem Cells (CSCs) express distinct surface markers and have unique functional properties that distinguish them from the rest of cells in a tumour. There been variability identity CSC serous adenocarcinoma ovary. We taken composite approach for evaluating together with assays primary tumours (n = 20). Expression were evaluated by flow cytometry, immunofluorescence (IF) immunohistochemistry (IHC) cell lines 8), malignant (PMC, n 20) normal ovary 2). The ALDEFLUOR assay was used...
<title>Abstract</title> Background Platinum-based chemotherapy regimens are a mainstay in the management of ovarian cancer (OC), but emergence chemoresistance poses significant clinical challenge. The persistence stem cells (OCSCs) at end primary treatment contributes to disease recurrence. Here, we hypothesized that extracellular matrix protects CSCs during and supports their tumorigenic functions by activating integrin-linked kinase (ILK), key enzyme drug resistance. Methods TCGA datasets...
LASP-1 was identified as a protein following mass spectrometric analysis of phosphoproteins consequent to signaling by ErbB2 in SKOV-3 cells. It has been previously an oncogene and is located on chromosomal arm 17q 0.76 Mb centromeric ErbB2. expressed serous ovarian cancer cell lines 40 kDa protein. In cells, it phosphorylated inhibited Lapatinib CP7274714. co-immunoprecipitated with suggesting direct interaction. This interaction phosphorylation were independent the kinase activity...
Abstract The receptor tyrosine kinase c-ErbB2 is amplified in breast and ovarian cancer. linear pathways through which signals by are transduced well known. However, second generation questions that address spatial aspects of signaling remain. To this, we have undertaken a mass spectrometry approach to identify phosphoproteins. We used two inhibitors, Lapatinib CP724714, inhibit phosphorylation SKOV-3, an cancer cell line endogenously overexpresses was grown culture without serum for 72 hrs....
The traditional view of tumour vascularization is that tumours acquire blood supply from the neighbouring normal stroma. However, recently origin endothelial cells or pericytes in part has been shown to be derived cancer stem (CSCs) glioblastoma. In high grade serous ovarian (HGSOC), not known. Our objective was determine if components a vessel and lymphatic are CSCs cancer. Using spheroids as an vitro model, we have evaluated role primary malignant (PMCs) patients with adenocarcinoma ovary...
Abstract Angiogenesis is required for tumor growth and metastasis. The conventional view of tumour angiogenesis that tumours get their blood supply from the neighbouring normal stroma. However, recently origin endothelial cells or pericytes in part has been shown to be derived cancer stem (CSC) glioma. spread ovarian (SOC) different not known. Using spheroids as an vitro model (which enriched CSC), we have evaluated role CSC primary malignant (PMCs) patients with serous adenocarcinoma ovary...
Abstract Ovarian cancer is one of the most lethal gynecological malignancies as patients are diagnosed at an advanced stage and have a poor prognosis. Several studies prospectively isolated stem cells (CSCs) from samples tumor with serous adenocarcinoma ovary (SOC). This has been achieved by using cell surface antigens or functional assays. Targeting this subpopulation could be critical to overcome drug resistance, recurrence, hence improve survival patients. The PI3K pathway deregulated in...
Abstract Ovarian cancer is the most common cause of mortality among gynecological cancers, despite advances in treatment. Recurrence and due to development drug resistance. One reasons for resistance persistence stem cells. To understand role CSCs, it essential capture propagate cells continuously culture. Reprogramming induced pluripotent (iPSCs) an approach achieve this. An ovarian cell line, PEO4 (high grade serous adenocarcinoma), was initially reprogrammed into iPSCs using classical...