A5012420281- Ovarian cancer diagnosis and treatment
- Pluripotent Stem Cells Research
- CRISPR and Genetic Engineering
- HER2/EGFR in Cancer Research
- Cancer Cells and Metastasis
- Epigenetics and DNA Methylation
- Cancer-related molecular mechanisms research
- Renal and related cancers
- RNA modifications and cancer
- Cancer-related Molecular Pathways
- Lymphatic System and Diseases
- Hedgehog Signaling Pathway Studies
- Glycosylation and Glycoproteins Research
- RNA Interference and Gene Delivery
- Kruppel-like factors research
- Breast Cancer Treatment Studies
- CAR-T cell therapy research
- 3D Printing in Biomedical Research
- Click Chemistry and Applications
- Cancer, Hypoxia, and Metabolism
- SARS-CoV-2 and COVID-19 Research
- Computational Drug Discovery Methods
- Wnt/β-catenin signaling in development and cancer
- Immunotherapy and Immune Responses
- Bioactive Compounds and Antitumor Agents
Cancer Institute (WIA)
2015-2025
Jubilee Mission Medical College and Research Institute
2023
National Research Council Canada
2021-2022
Abstract Lipid based nanocarriers are one of the most effective drug delivery systems that is evident from recent COVID-19 mRNA vaccines. The main objective this study was to evaluate toxicity six lipid formulations with three surface charges—anionic, neutral or cationic, establish certified reference materials (CRMs) for liposomes and siRNA loaded nanoparticles (LNP-siRNA). Cytotoxicity assessed by a proliferation assay in adherent non-adherent cell lines. High concentration LNP-siRNAs did...
TCGA has identified predominant somatic copy number alterations (SCNA) affecting numerous genes in HGSOC. To identify cancer-driver from the regions of SCNA, we have devised a scoring system that integrates information different genetic alterations. Applying this to TCGA-HGSOC dataset (n = 316) several well-known and novel putative cancer We functionally validated roles two previously unknown genes, RNF144B PPP2R2A. RNF144B, an E3 ubiquitin-ligase is amplified overexpressed 16% HGSOC (TCGA)....
ErbB2 is an important receptor tyrosine kinase and a member of the ErbB family. Although it does not have specific ligand, transmits signals downstream by heterodimerization with other receptors in It plays major role variety cellular responses like proliferation, differentiation, adhesion. amplified at DNA level breast cancer (20%-30%) gastric (10%-20%), trastuzumab effective as therapeutic antibody. This review critical analysis currently published data on signaling pathways interacting...
Background: The aim of this study was to evaluate microvessel density (MVD) by expression CD31 andCLEC14A in core biopsies from previously untreated patients with locally advanced breast cancer (LABC) and assessits prognostic significance. Methods: MVD evaluated needle (n = 92), collected prior anytreatment, who were diagnosed (LABC). Immunohistochemistry forexpression CLEC14A performed on these tumours. median duration follow-up 9.3 years.The effect factors disease free survival (DFS)...
High grade serous ovarian cancer is characterized by relatively few mutations occurring at low frequency, except in TP53.However other genetic aberrations such as copy number variation alter numerous oncogenes and tumor suppressor genes.Oncogenes are positive regulators of tumorigenesis play a critical role cell growth, proliferation, survival.Accumulating evidence suggests that they crucial for the development progression high carcinoma (HGSOC).Though many have been identified, no...
Conventional suspension cultures have been used in Acute Myeloid Leukemia(AML) research to study its biology as well screen any drug molecules, since inception.Co-culture models of AML cells and other stromal 3 dimensional (3D) culture gained much attention recently.These try recapitulate the tumour microenvironment are found be more suitable than cultures.Though animal being used, they require time, effort facilities hence, it is essential develop cell for high-throughput screening...
Abstract Cancer Stem Cells (CSCs) express distinct surface markers and have unique functional properties that distinguish them from the rest of cells in a tumour. There been variability identity CSC serous adenocarcinoma ovary. We taken composite approach for evaluating together with assays primary tumours (n = 20). Expression were evaluated by flow cytometry, immunofluorescence (IF) immunohistochemistry (IHC) cell lines 8), malignant (PMC, n 20) normal ovary 2). The ALDEFLUOR assay was used...
LASP-1 was identified as a protein following mass spectrometric analysis of phosphoproteins consequent to signaling by ErbB2 in SKOV-3 cells. It has been previously an oncogene and is located on chromosomal arm 17q 0.76 Mb centromeric ErbB2. expressed serous ovarian cancer cell lines 40 kDa protein. In cells, it phosphorylated inhibited Lapatinib CP7274714. co-immunoprecipitated with suggesting direct interaction. This interaction phosphorylation were independent the kinase activity...
The traditional view of tumour vascularization is that tumours acquire blood supply from the neighbouring normal stroma. However, recently origin endothelial cells or pericytes in part has been shown to be derived cancer stem (CSCs) glioblastoma. In high grade serous ovarian (HGSOC), not known. Our objective was determine if components a vessel and lymphatic are CSCs cancer. Using spheroids as an vitro model, we have evaluated role primary malignant (PMCs) patients with adenocarcinoma ovary...
Introduction: Suicide is the intentional action taken by a person to end his or her own life. It major public health and mental problem. This study was an attempt find out effectiveness of suicide prevention training package on level knowledge about risk management among general population at Thrissur. Objectives: To assess before after intervention, compare pretest posttest people giving associate in selected socio- demographic characteristics management. Methodology: The conducted 50...
Abstract Ovarian cancer is the most common cause of mortality among gynecological cancers, despite advances in treatment. Recurrence and due to development drug resistance. One reasons for resistance persistence stem cells. To understand role CSCs, it essential capture propagate cells continuously culture. Reprogramming induced pluripotent (iPSCs) an approach achieve this. An ovarian cell line, PEO4 (high grade serous adenocarcinoma), was initially reprogrammed into iPSCs using classical...
Abstract Lipid based nanocarriers are one of the most effective drug delivery systems that is evident from recent COVID-19 mRNA vaccines. The main objective this study was to evaluate toxicity six lipid formulations with three surface charges - anionic, neutral or cationic, establish certified reference materials (CRMs) for liposomes and siRNA loaded nanoparticles (LNP-siRNA). Cytotoxicity assessed by a proliferation assay in adherent non-adherent cell lines. High concentration LNP-siRNAs...
Abstract Ovarian cancer is the most common cause of death due to gynaecological cancer. Comprehensive genomic analysis by TCGA consortium HGSOC (high grade serous ovarian cancer) has not identified mutated genes (except p53 and BRCA) at sufficient frequency. Copy number variations (CNV's) are predominant in HGSOC. However, it challenging identify driver that contribute tumorigenesis. Using primarily copy data from for (n=316) we have devised a scoring method new involved pathogenesis The...