A5061727601- Lymphoma Diagnosis and Treatment
- Acute Lymphoblastic Leukemia research
- Chronic Lymphocytic Leukemia Research
- Acute Myeloid Leukemia Research
- Chronic Myeloid Leukemia Treatments
- Lung Cancer Treatments and Mutations
- Neutropenia and Cancer Infections
- Testicular diseases and treatments
- CNS Lymphoma Diagnosis and Treatment
- Viral-associated cancers and disorders
- Childhood Cancer Survivors' Quality of Life
- Neuroblastoma Research and Treatments
- Nausea and vomiting management
- Cancer Treatment and Pharmacology
- Hematopoietic Stem Cell Transplantation
- Breast Cancer Treatment Studies
- Antifungal resistance and susceptibility
- HER2/EGFR in Cancer Research
- Lung Cancer Diagnosis and Treatment
- Medical Imaging Techniques and Applications
- Anesthesia and Pain Management
- Glioma Diagnosis and Treatment
- Advanced Breast Cancer Therapies
- Sarcoma Diagnosis and Treatment
- Anesthesia and Sedative Agents
Cancer Institute (WIA)
2014-2023
Castle Hill Hospital
2009
International Network for Cancer Treatment and Research
2004
Dr. Kariadi Hospital
2000
There is limited data on the impact of treatment interruptions due to nonadherence in patients with chronic phase myeloid leukemia (CP-CML) treated Imatinib. We looked at factors (including adherence therapy) affecting outcome a large cohort CP-CML. All 516 received Imatinib free-of-cost through company sponsored scheme, which mandated regular three monthly visits for drug procurement. Data regarding disease characteristics, and outcomes, were obtained from records. Unwarranted interruption...
Lung cancer is the most common cause of mortality in world. There are limited studies on survival outcomes lung developing countries such as India. This study analyzed patients with who underwent treatment at Cancer Institute (WIA), Chennai, India, between 2006 and 2015 to determine identify prognostic factors.In all, 678 treatment. Median age was 58 years, 91% had non-small-cell (NSCLC). Testing for epidermal growth factor receptor mutation performed 132 347 61 (46%) were positive.Median...
Neoadjuvant chemoradiation for rectal cancers may result in complete clinical response (cCR) some patients. The aim of this study was to analyze the long-term outcomes such patients a tertiary cancer center.Patients with who had cCR neoadjuvant were divided into two groups: Group A (n=23) did not undergo surgery, and B (n=10) underwent elective surgery. recurrence patterns survival compared between groups.After median follow-up 72 months (range 12-180), seven (30%) developed an isolated...
Abstract Background Fosaprepitant is a neurokinin‐1 receptor antagonist, approved for the prevention of chemotherapy‐induced nausea and vomiting. The data on use fosaprepitant in children are limited therefore we conducted phase III randomized controlled trial. Procedure Children aged 1‐12 years scheduled to receive moderately or highly emetogenic chemotherapy were randomly assigned arm‐A (fosaprepitant) arm‐B (placebo). recruited received intravenous ondansetron plus dexamethasone followed...
Abstract Background Breakthrough chemotherapy–induced vomiting (CIV) is defined as CIV occurring after adequate antiemetic prophylaxis. Olanzapine and metoclopramide are two drugs recommended for the treatment of breakthrough in children, without evidence. We conducted an open‐label, single‐center, phase 3 randomized controlled trial comparing safety efficacy olanzapine treating CIV. Procedure Children aged 5‐18 years who developed receiving highly emetogenic chemotherapy or moderately were...
Improved survival after childhood cancer is attributed to intensive, aggressive therapy, adverse sequelae of which can manifest months years completion treatment. There little information about the late effects both and its therapy in survivors India.To determine long-term associated with attending a tertiary center India.We studied 155 consecutive who were ≤14 at time diagnosis had completed 3 follow-up. The study included complete history clinical examination, specific investigations...
There is a paucity of data on the outcome following treatment for acute lymphoblastic leukemia (ALL) from developing countries.Two hundred and thirty-eight consecutive patients with ALL <30 years age diagnosed between January 2005 December 2011 were analyzed retrospectively. Patients treated modified Berlin, Frankfurt, Munster 95 protocol. Event-free survival (EFS) was calculated using Kaplan-Meier analysis variables compared log-rank test.The EFS 63.4% at median follow-up 32.7 months. On...
Pediatric Hodgkin lymphoma (HL) is a highly curable malignancy. Outcomes for pediatric HL may vary between developed and developing countries multiple reasons. This study was conducted to ascertain the outcomes of children with at our center identify risk factors recurrent disease.We analyzed 172 consecutive, previously untreated patients presenting from 2001 2010. Patients were treated either adriamycin, bleomycin, vinblastine, dacarbazine or cyclophosphamide, vincristine, prednisone,...
Lung cancer continues to remain as one of the leading causes morbidity and mortality worldwide, despite decreasing trends in smoking prevalence worldwide. An earlier study from authors' institute reported increasing "Nonsmoking associated lung cancers."
Crowded outpatient clinics and common wards in many hospitals low middle-income countries predispose children, caregivers, health care workers to infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We report on the clinical features outcomes of 15 children cancer at our center who tested positive for SARS-CoV-2. Five out patients were symptomatic, one patient required intensive support. All study have recovered from SARS-CoV-2 without any sequelae resumed their treatment.
The NOTCH1 signaling pathway is essential for hematopoiesis and a critical regulatory step T-cell proliferation maturation. E3 ubiquitin ligase FBXW7 controls protein stability. Mutations in NOTCH1/FBXW7 activate NOTCH are of prognostic significance patients with acute lymphoblastic leukemia (T-ALL). In this study we analyzed mutations 50 South Indian T-ALL treated by modified ALL BFM 95 regimen. hot spot exons (HD-N, HD-C, TAD, PEST) 9 the 10 were polymerase chain reaction amplified...
NOTCH1/FBXW7 mutations trigger oncogenic NOTCH1 signaling and its downstream target genes play crucial roles in the molecular pathogenesis of T-cell acute lymphoblastic leukemia (T-ALL). In present study, FBXW7 were studied 25 primary T-ALL samples. All 34 exons hotspot (exon 9 exon 10) polymerase chain reaction amplified sequenced for mutations. Our results showed that 13/25 (52%) NOTCH1-mutated, which 11 patients (44%) mutation exons. Four (16%) had non-hotspot NOTCH1. Notably, 2 (8%)...
Germ cell tumor is a rare malignancy accounting for 3% of all pediatric tumors. They are highly curable malignancies. The aim this study was to evaluate the clinical presentation, management, and outcome in subset.The population included 40 patients with age less than 18 years at diagnosis. were treated Cancer Institute Chennai, India from 1990 2002. analyzed various clinical, pathologic presentations, survival outcomes. Actuarial method used estimate overall relapse-free survival.The mean...
Cervical cancer is the third most common in India. There limited data on treatment of relapsed cervical from India; therefore, we report outcomes patients with recurrent who were treated palliative chemotherapy (CT).This was a retrospective study received CT January 2012 to December 2016. The demographic details, clinical profile and survival collected. Patients carboplatin or paclitaxel carboplatin. Local radiation given for symptomatic patients. assessed responses clinically and/or...