A5077007834- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Circular RNAs in diseases
- RNA modifications and cancer
- COVID-19 epidemiological studies
- RNA Research and Splicing
- Extracellular vesicles in disease
- Genetics and Neurodevelopmental Disorders
- Cancer-related Molecular Pathways
- COVID-19 and Mental Health
- Cancer Cells and Metastasis
- Radiomics and Machine Learning in Medical Imaging
- Ubiquitin and proteasome pathways
- Peptidase Inhibition and Analysis
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Epigenetics and DNA Methylation
- Mycobacterium research and diagnosis
- Genomic variations and chromosomal abnormalities
- HER2/EGFR in Cancer Research
- Ferroptosis and cancer prognosis
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Endometrial and Cervical Cancer Treatments
- Folate and B Vitamins Research
- DNA Repair Mechanisms
Guangzhou Medical University
2016-2025
Jiangmen Central Hospital
2025
State Key Laboratory of Respiratory Disease
2013-2021
First Affiliated Hospital of Guangzhou Medical University
2017-2021
Guangzhou Center for Disease Control and Prevention
2020-2021
Third Affiliated Hospital of Guangzhou Medical University
2016-2021
Weatherford College
2021
Ludwig-Maximilians-Universität München
2020
Bridge University
2020
Guangzhou Chest Hospital
2020
Reprogrammed energy metabolism as an emerging hallmark of cancer has recently drawn special attention since it facilitate cell growth and proliferation. Recently, long noncoding RNAs (lncRNAs) have been served key regulators implicated in tumor development progression by promoting proliferation, invasion metastasis. However, the associations lncRNAs with cellular lung (LC) need to be clarified. Here, we conducted bioinformatics analysis found insulin-like factor binding protein 4–1...
Soil waterlogging is a major environmental stress that suppresses maize (Zea mays) growth and yield. To identify quantitative trait loci (QTL) associated with tolerance at the seedling stage, F2 population consisting of 288 F2:3 lines was created from cross between two genotypes, 'HZ32' (waterlogging-tolerant) 'K12' (waterlogging-sensitive). The genotyped base-map 1710·5 cM length constructed an average marker space 11·5 based on 177 SSR (simple sequence repeat) markers. QTL root length, dry...
WW domain-containing oxidoreductase (WWOX) is a tumor suppressor that has been reported to lose function due genetic alterations in several cancers. WWOX maps the common chromosomal fragile site FRA16D and copy number variations (CNVs) were found within this gene. In study, we investigated association between CNVs of lung cancer risk four independent case-control studies, which are on 2942 cases 3074 cancer-free controls southern, eastern northern Chinese. A CNV-67048 was genotyped by Taqman...
Identification of mucin modulators is remarkable significance to facilitate mucin-based antineoplastic therapy. However, little known about circular RNAs (circRNAs) on regulating mucins. Dysregulated mucins and circRNAs were identified via high-throughput sequencing their relationships with lung cancer survival analyzed in tumor samples 141 patients. The biological functions circRABL2B determined gain- loss-of-function experiments exosome-packaged treatment cells, patient-derived organoids...
Abstract Background Lung cancer is the most prevalent worldwide, with non-small cell lung (NSCLC) accounting for 85% of all cases. Circular RNAs(circRNA) play crucial roles in regulating progression cancer. Despite identification a large number circRNAs, their expression patterns, functions, and mechanisms action NSCLC development remain unclear.This study aims to investigate transcriptional expressions, potential circRNA hsa_circ_0050386 NSCLC. Methods Quantitative real-time polymerase...
A non-invasive method to distinguish potential lung cancer patients would improve prevention. We employed the RNA-sequencing analysis profile serum exosomal long non-coding RNAs (lncRNAs) from non-small cell (NSCLC) and pneumonia controls, then determined diagnostic prognostic value of a promising lncRNA in four datasets. identified 90 dysregulated lncRNAs for NSCLC found most significant was novel isoform linc01125. Serum linc01125 could cases disease-free tuberculosis with area under curve...
Rationale: Epithelial–mesenchymal transition (EMT) plays a key role in the development of chronic obstructive pulmonary disease (COPD) and lung cancer.Objectives: There are five major EMT regulatory genes (Snai1, Slug, Zeb1, Zeb2, Twist1) involved EMT. We hypothesized that germline variants these may influence both diseases.Methods: Seven genetic were genotyped two two-stage case-control studies with 2,072 cancer cases 2,077 control subjects, 1,791 patients COPD 1,940 subjects to show their...
Little is known about long non‐coding RNA (lncRNA) related to innate immunity in lung cancer. The advanced glycosylation end‐product specific receptor (AGER) belongs the immunoglobulin superfamily, and currently, only immune pattern‐recognition whose abnormal expression has been detected We aimed explore lncRNA that AGER test its effect on carcinogenesis. selected one chromosome location close proximity namely lnc‐AGER‐1 (defined as lncAGER). of lncAGER was tested 276 pairs cancer tissues...
Many long non-coding RNAs (lncRNAs) have emerged as good biomarkers and potential therapeutic targets for various cancers. We aimed to get a detailed understanding of the lncRNA landscape that is associated with lung cancer survival. A comparative analysis between our RNA sequencing (RNA-seq) data TCGA datasets was conducted reveal lncRNAs significant correlations survival then association most promising validated in cohort 243 patients. Comparing RNA-seq ones, 84 dysregulated were...
Recently, several genome-wide association studies (GWAS) have identified many susceptible single nucleotide polymorphisms (SNPs) for chronic obstructive pulmonary disease (COPD) and lung cancer which are two closely related diseases. Among those SNPs, some of them shared by both the diseases, reflecting there is possible genetic similarity between Here we tested hypothesis that whether SNPs common predictor risks or prognosis COPD cancer. Two (rs6495309 rs1051730) located in nicotinic...
CD133 is a pivotal marker of cancer stem cells (CSCs), which involved in tumorigenesis and progression. Recent studies have identified to be prognostic factor for rested with its expression genetic variants. Here, we hypothesized that the single nuclear polymorphisms (SNPs) may associated lung risk prognosis. Based on three independent case–control analyses total 2332 cases 2457 controls, gene-based association analysis 13 suggested susceptible gene ( P = 0.043) SNP rs2240688A>C...
Abstract Purpose: This study was implemented to investigate the associations between SNP in mature microRNA (miRNA) sequence and lung cancer prognosis verify function of those SNP. Experimental Design: Eight SNPs (rs3746444T>C hsa-mir-499, rs4919510C>G hsa-mir-608, rs13299349G>A hsa-mir-3152, rs12220909G>C hsa-mir-4293, rs2168518G>A hsa-mir-4513, rs8078913T>C hsa-mir-4520a, rs11237828T>C hsa-mir-5579, rs9295535T>C hsa-mir-5689) were...
Abstract Background The epithelial-mesenchymal transition (EMT) plays an indispensable role in the development and progression of Endometrial cancer (EC). Nevertheless, little evidence is reported to uncover functionality application EMT-related molecules prognosis EC. This study aims develop novel molecular markers for prediction patients with Methods RNA sequencing profiles EC obtained from Cancer Genome Atlas (TCGA) database were used screen differential expression genes (DEGs) between...
Abundant evidence has illustrated that long non-coding RNA (lncRNA) plays a vital role in the regulation of tumor development and progression. Ectopic expression novel lncRNA, termed lnc-AGER-1, been discovered cancers, this lncRNA was reported to exert an anti-tumor effect. However, its biological mechanism remains unelucidated colorectal cancer.A total 159 paired cancer specimens adjacent tissues applied detect lnc-AGER-1 by quantitative Real-time PCR (qRT-PCR), series functional assays...
Abstract The WW domain‐containing oxidoreductase ( WWOX ) gene is an identified tumor suppressor gene, of which several single nucleotide polymorphisms have been reported to contribute cancer susceptibility. We hypothesized that genetic variations in are associated with lung risk. In two independent case–control studies conducted southern and eastern Chinese, we genotyped five tagSNPs (rs10220974C > T, rs3764340C G, rs12918952G A, rs383362G rs12828G A) 1,559 cases 1,679 controls. Logistic...
Genomic imbalance referring to somatic variation in chromosome copies represents the most frequent event tumorigenesis. Germline copy number variations (gCNVs) overlapping regions of genomic harbor similar structural characteristics and thus influence tumor susceptibility. We aimed test effects such gCNVs on risk lung cancer chronic obstructive pulmonary disease (COPD). was determined by array comparative hybridization (aCGH), common at these were genotyped cancer-based COPD-based...