A5002936160- Gastric Cancer Management and Outcomes
- Colorectal Cancer Surgical Treatments
- Gastrointestinal Tumor Research and Treatment
- Wound Healing and Treatments
- Mesenchymal stem cell research
- Esophageal Cancer Research and Treatment
- Colorectal and Anal Carcinomas
- Colorectal Cancer Treatments and Studies
- Graphene and Nanomaterials Applications
- Multiple and Secondary Primary Cancers
- Gastrointestinal disorders and treatments
- Enhanced Recovery After Surgery
- Nanoplatforms for cancer theranostics
- Metastasis and carcinoma case studies
- Diabetic Foot Ulcer Assessment and Management
- Cancer Immunotherapy and Biomarkers
- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- Advanced Glycation End Products research
- Anatomy and Medical Technology
- Burn Injury Management and Outcomes
- Esophageal and GI Pathology
- Diverticular Disease and Complications
- Bone Tissue Engineering Materials
- Lung Cancer Diagnosis and Treatment
Union Hospital
2023-2025
Huazhong University of Science and Technology
2023-2025
Union Hospital
2023-2025
Hubei Zhongshan Hospital
2023-2024
Southern Medical University
2016-2024
Wuhan University
2023-2024
Guangdong Academy of Medical Sciences
2016-2024
Guangdong Provincial People's Hospital
2013-2024
Wuhan Union Hospital
2024
Huazhong University of Science and Technology Hospital
2023
The clinical applications of currently used photosensitizers are limited by high costs, inconvenient preparation, suboptimal biodegradability, and a lack biological activity. Humic acids (HAs) show photothermal activity can be as photosensitizer for therapy. In the presence various functional groups, HAs endowed with anti-inflammatory antioxidant activities. solubility is dependent on pH value, which soluble in neutral to alkaline conditions undergoes conformational change coiled compact...
Abstract The drug‐resistant bacterial‐infected skin wound is still a severe healthcare problem. Uncontrolled bacterial infection, abundant reactive oxygen species (ROS) content, and prolonged inflammatory response are detrimental to healing. Moreover, excessive vessel growth can result in unsatisfactory scar formation. Herein, three‐step regenerative strategy based on bilayered gelatin/acryloyl β ‐cyclodextrin (BGACD) hydrogel containing physical host–guest complexations chemical crosslinks...
The diabetic wounds remain to be unsettled clinically, with chronic characterized by drug-resistant bacterial infections, compromised angiogenesis and oxidative damage the microenvironment. To ameliorate stress applying antioxidant treatment in wound site, we explore function of folliculin-interacting protein 1 (FNIP1), a mitochondrial gatekeeper works alter morphology, reduce phosphorylation protect cells from unwarranted ROS accumulation. And our vitro experiments showed effects FNIP1...
The diabetic wounds remain to be unsettled clinically, with chronic characterized by drug-resistant bacterial infections, compromised angiogenesis and oxidative damage the microenvironment. Hence, a novel designed glucose-responsive HA-PBA-FA/EN106 hydrogel is introduced for improving wound healing. Due dynamic phenylboronate ester structure phenylboronic acid group between hyaluronic (HA) (PBA), able realize release of drugs. Fulvic (FA) added in hydrogel, which not only severs as...
Adenocarcinoma of the esophagogastric junction (AEG) is a type tumor that arises at anatomical esophagus and stomach. Although AEG commonly classified as subtype gastric adenocarcinoma (GAC), microenvironment (TME) remains poorly understood. To address this issue, we conducted single-cell RNA sequencing (scRNA-seq) on adjacent normal tissues from four patients performed integrated analysis with publicly available GAC datasets. Our study for first time comprehensively deciphered TME landscape...
Background: Recently, multiple lines of evidence have demonstrated that linc00662 serves as an oncogene in various cancers. However, the exact mechanism oncogenesis mediated by colorectal cancer (CRC) remains unknown. In this study, we aimed to explore biological role regulation CRC progression. Methods: Both gene expression omnibus (GEO) and genome atlas (TCGA) datasets were used evaluate linc00662. RT-qPCR was analyze linc00662, miR-497-5p, AVL9 clinical samples cell lines. Cell Counting...
Bone nonunion poses an urgent clinical challenge that needs to be addressed. Recent studies have revealed the metabolic microenvironment plays a vital role in fracture healing. Macrophages and bone marrow-derived mesenchymal stromal cells (BMSCs) are important targets for therapeutic interventions fractures. Itaconate is TCA cycle metabolite has emerged as potent macrophage immunomodulator limits inflammatory response. During osteogenic differentiation, BMSCs tend undergo aerobic glycolysis...
Abstract Infected fracture healing is a complicated process that includes intricate interactions at the cellular and molecular levels. In addition to angiogenesis osteogenesis, significance of neurogenesis in has also been recognized recent years. Here, nanocomposite hydrogel containing pH‐responsive zinc‐gallium‐humic acids (HAs) nanoparticles developed. Through timed release Zn 2+ , Ga 3+ HAs, exhibits potent antibacterial effects promotes angiogenesis, neurogenesis. The enhanced further...
Thetreatment of infected wounds is currently a major challenge in clinical medicine, and enhancing antimicrobial angiogenic capacity one the most common strategies. However, current treatment makes it difficult to balance effect early stage later stages wound healing, leading an increased rate poor prognosis. Here, we present nanoconductive hydrogel EF@S-HGM, consisting HGM with ECGS, FMLP, SWCNT. The host-guest supramolecular macromolecule (HGM) biocompatible can be injected situ wound....
Purpose: There is mounting evidence to indicate that microRNA-17 (miR-17) expressed and functionally involved in human cancers. However, the molecular mechanism underlying role of miR-17 colorectal cancer (CRC) remains largely unclear. This study aims reveal biological function cancer. Materials methods: The expression CRC cells tissues was examined using qRT-PCR. Cell proliferation migration assays were performed after transfection with an mimic inhibitors. potential gene targets predicted...
This retrospective study compared the outcomes of laparoscopic complete mesocolic excision (CME) guided by superior mesenteric artery with conventional radical resection (CRR) performed for right-sided colon cancer.Patients cancer underwent CME (n=107; January 2011 to December 2015) or CRR (n=60; 2008 2010).The 2 groups were comparable regarding age, gender, body mass index, maximum tumor diameter, and stage. In group, distances between high vascular tie (HVT; 12.6 cm), closest bowel wall...
Gastrointestinal stromal tumors (GISTs) are commonly known to be derived from the gastrointestinal (GI) tract, but recently there have been more and literature describing lesions with similar pathological immunohistochemical resembling GISTs located outside GI they termed as extra-GISTs (eGISTs). However, due rare incidence of eGISTs, its association survival outcomes is poorly understood, especially in Chinese population. Here, we aimed identify risk factors eGISTs assess their overall (OS)...