A5101430016- Cancer-related molecular mechanisms research
- Ferroptosis and cancer prognosis
- RNA modifications and cancer
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Cancer Research and Treatments
- Traffic Prediction and Management Techniques
- Toxin Mechanisms and Immunotoxins
- Education and Work Dynamics
- Lung Cancer Treatments and Mutations
- Helicobacter pylori-related gastroenterology studies
- Medicinal Plant Pharmacodynamics Research
- Neuroendocrine Tumor Research Advances
- Physiological and biochemical adaptations
- Traffic control and management
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Immune Response and Inflammation
- Transportation Planning and Optimization
- Autophagy in Disease and Therapy
- Innovative Teaching Methods
- Lung Cancer Research Studies
- Spaceflight effects on biology
- Ocular Infections and Treatments
- Cancer, Hypoxia, and Metabolism
- NF-κB Signaling Pathways
China Mobile (China)
2024
Qiqihar Medical University
2008-2024
First Affiliated Hospital of GuangXi Medical University
2022
Guangxi Medical University
2022
Sixth Affiliated Hospital of Sun Yat-sen University
2022
Sun Yat-sen University
2022
Qingdao Municipal Hospital
2017-2021
Qingdao University
2017-2021
State Key Laboratory of Respiratory Disease
2021
China Pharmaceutical University
2013
Present study aims to identify the essential mRNAs responsible for development of brain neurovascular-related metastases (BNM) among lung adenocarcinoma (LUAD) patients. Further, we attempted predict more accurately and prevent their in LUAD patients.Transcriptome data analysis was used differentially expressed (DEMs) associated with metastasis, thereby ferroptosis index (FPI) is calculated using a computational model. Meanwhile, DEmRNAs linked FPI, metastasis were derived by intersection...
Purpose: We aimed to detect the expression of HIF-1<TEX>${\alpha}$</TEX>, VEGF, HPSE-1 and CD31 in SKOV3 xenografts nude mice treated with different doses ionizing radiation, trying explore possible mechanism hypoxia radioresistance. Methods: Nude bearing were randomly divided into 4 groups: Group A (control group, no radiation), B (treated low dose radiation: 50cGy), C high 300cGy), D ( combined radiation from : 50cGy first 300cGy after 6h interval). The mRNA levels HIF-1 VEGF each group...
ALK-positive disease is characterized by the presence of ALK gene rearrangements that encode driver fusion oncoproteins. EML4-ALK regarded as most common type in advanced nonsmall cell lung cancers. STRN-ALK a novel partner NSCLC and considered sensitive to targeted therapy. However, there was no study regarding effective therapy for double variants EGFR-resistant mutant cancer. TP53, RB1, EGFR exon 21 L858R were found tumor tissues plasma from patients with capture-based NGS. After 3 months...
The incidence of gallbladder carcinoma (GBM) in China has increased recent years. Here, the functional mechanism lncRNA TTN-AS1 GBC was preliminary elucidated.The expression levels TTN-AS1, miR-107, and HMGA1 tissues cell lines were assessed by RT-qPCR. Cell proliferation measured MTT assays. invasion migration abilities evaluated Transwell relationship between miR-107 or confirmed luciferase reporter assay.Upregulation downregulation detected GBC. Furthermore, expressions mutually inhibited...
Abstract Background Accumulating researchers have recognized mitophagy as a key player in tumors, but few studies investigated its role the tumor microenvironment (TME). Advances technology of single-cell RNA sequencing (scRNA-seq) allowed unveiling concealed features TME at cellular resolution. This study aimed to elucidate within colorectal cancer (CRC) and establish mitophagy-mediated risk model. Methods We assessed mitophagy-related pathway activities both tissue levels. Subsequently, an...
Purpose To investigate the latent mechanisms of hepatocellular carcinoma (HCC) and find therapeutic targets. Methods Differentially expressed overall survival related genes HCC, cell death were intersected to obtain target genes. These analyzed using ROC curve for diagnosing HCC. RT-qPCR Western blot performed detect expression level Wound healing tests with or without si-HSPA4. Potential ceRNA axis was forecasted TargetScan miRanda dual luciferase reporter gene assay used verify results....
The application of deep reinforcement learning techniques to adaptive traffic signal control is effective in reducing congestion, due its advantages over more traditional experience-based or model-driven methods. Although numerous studies have been conducted on control, many them suffer from issues such as unreasonable phase settings and long model-building times complex environments. By analyzing the spatial-temporal characteristics intersection volume, this paper puts forward an automatic...
To study function and relativity of autophagy in NSCLC treated with ginsenoside Rh2, to explore some molecular mechanism that Rh2 induces A549 cell lines apoptosis. Methods: Immunofluorescence assays detects activity caspase-8 / 9 expression autophagy-related molecules Beclin-1 LC3. Results: shows that, 20μg/mL acts 3h, fluorescent intensity marks level significantly increases, it means rises increases. Fluorescent LC3and caspase-9 has increase but without significant change 1-6h, LC3 no...
Objective To investigate the inhibitory effects of CIK on proliferation Lewis lung carcinoma cell line and growth transplanted in C57BL/6N mice vivo.Methods cells were induced by culturing PBMC with regular method.The was measured MTT assay.Uhramicrostrueture observed under a transmission electron microscope.Flowcytometric analysis used to detect apoptosis.Ultrastructural observation expressions FasL individually determined immunocytochemistry(ICC) analysis.Results Electron microscopic...
Objective To discuss the effect of teaching mode technological pedagogical and content knowledge in biochemistry theory teaching. Methods 400 students 8 classes clinical medicine undergraduate Grade 2013 were selected randomly divided into 2 groups. The traditional was applied control group 198 1-4 classes, while experimental 202 5-8 classes. 385 medical undergraduates 2014 189 adopted mode, 196 which used micro-lesson network platform as learning resource superior to flipped...