A5101568586- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Cancer, Hypoxia, and Metabolism
- RNA modifications and cancer
- Lung Cancer Treatments and Mutations
- Cancer Cells and Metastasis
- Cancer Research and Treatments
- Cancer, Lipids, and Metabolism
- Ubiquitin and proteasome pathways
- Lung Cancer Diagnosis and Treatment
- Glioma Diagnosis and Treatment
- Ferroptosis and cancer prognosis
- Spaceflight effects on biology
- Neurological Disease Mechanisms and Treatments
- Lipid metabolism and disorders
- Peptidase Inhibition and Analysis
- Medical Research and Treatments
- NF-κB Signaling Pathways
- Epigenetics and DNA Methylation
- CAR-T cell therapy research
- Physiological and biochemical adaptations
- RNA Research and Splicing
- Healthcare and Venom Research
- Histone Deacetylase Inhibitors Research
Mudanjiang Medical University
2013-2022
Xuzhou Medical College
2014-2017
Air Force Medical University
2002-2016
Tang Du Hospital
2016
Affiliated Hospital of Xuzhou Medical College
2014
Tongji Hospital
2014
Tongji University
2014
Qingdao University
2010
Affiliated Hospital of Qingdao University
2010
The identification of cancer stem cells (CSCs) has improved the understanding tumor occurrence and development. According to CSC theory, colorectal carcinoma (CRC) may be derived from these few cells. Thus, markers for CSCs lead investigation correlation with various clinicopathological features survival time in human CRC patients. Aldehyde dehydrogenase 1 (ALDH1) CD133 (also known as Prominin‑1 or AC133) were involved current study. aim present study was identify through explore value...
To investigate the interaction of miR‐1290 and LHX6 in gliomas, their influence on propagation metastasis glioma cells. The differential expression cells was identified by chip screening. level were determined qRT‐PCR Western blot. analyzed MTT assay, EdU incorporation, colony formation, while impact assessed transwell assay. relationship between testified luciferase reporter gliomas orthotopic implantation model nude mice established to tumor growth. Tumor volumes evaluated photon density,...
Hepatocellular carcinoma (HCC) is the most common form of adult liver cancer and accounts for approximately 90% all cases primary annually. Rhotekin (RTKN), which functions as a promoter, can be frequently detected in many human cancers, including gastric cancer, colorectal bladder carcinoma. The aim this study was to investigate role RTKN HCC. Using HCC cells tissues from patients with we demonstrated that significantly increased To examine effect on HCC, overexpressed or silenced HepG2...
We investigated the role of miR-301b in modulation proliferation, migration, and invasion bladder cancer (BLCA) cells. The expression EGR1 (early growth response gene 1) mRNA were analyzed by quantitative real-time polymerase chain reaction (qRT-PCR). A dual-luciferase reporter system was used to identify target relationship between EGR1. Cell cell cycle, apoptosis MTT assay, colony-forming flow cytometry, respectively. motility invasiveness assessed wound healing Transwell assays. proteins...
Abstract Background X-chromosome-linked IAP (XIAP) and nuclear factor-κB (NF-κB) are frequently overexpressed correlate closely with chemoradiotherapy resistance poor prognosis in many cancers. However, the significance of XIAP NF-κB expression radiotherapy sensitivity its effect on esophageal squamous cell carcinoma (ESCC) still unknown. The aim this study was to examine status ESCC patients undergoing postoperative after radical surgery, evaluate their clinical significance. Methods A...
A series of novel reduction-responsive micelles with tailored size were designed and prepared to release doxorubicin (DOX) for treating glioma, which developed based on amphiphilic block copolymer poly (2-ethyl-2-oxazoline)-b-poly (ε-caprolactone) (PEtOz-SS-PCL) the micelle could be regulated by designing polymer structure. The DOX-loaded PEtOz-SS-PCL had small rapid drug in reductive intracellular environments. Biodistribution vivo imaging studies C6 glioma mice tumor model showed that DOX...
Diabetic cardiomyopathy (DCM) is one of the cardiovascular complications diabetes mellitus independent hypertension, coronary disease, and other heart diseases. The development DCM multifactorial hard to detect at an early stage. Long non-coding RNA metastasis-associated lung adenocarcinoma transcript 1 (Malat1) emerging as a regulator DCM, underlying mechanism its role in has not been elaborated yet. In this study, we established mouse model via streptozocin injection evidenced by cell...
Since the identification of cancer stem cells (CSCs) a new understanding tumor occurrence and development has evolved. According to cell (SC) theory, colorectal carcinoma (CRC) SCs may be derived from mutations in normal intestinal cells. CSCs can defined by their origin (SCs or early progenitor cells). Thus, through shared marker between SCs, it is possible investigate association its expression various clinicopathological features patients with CRC. Aldehyde dehydrogenase 1 (ALDH1) an...
Background: Increasing evidence indicates that radioresistance remains a major problem in the treatment of patients with esophageal squamous cell carcinoma (ESCC). This study was designed to investigate expression microRNA-381 (miR-381) and its function ESCC. Methods: In this study, miR-381 first detected ESCC lines tissue samples by quantitative real-time polymerase chain reaction (qRT-PCR). Then, effects on growth, apoptosis, radiosensitivity cells were analyzed MTT, colony formation, flow...
Purpose: We aimed to detect the expression of HIF-1<TEX>${\alpha}$</TEX>, VEGF, HPSE-1 and CD31 in SKOV3 xenografts nude mice treated with different doses ionizing radiation, trying explore possible mechanism hypoxia radioresistance. Methods: Nude bearing were randomly divided into 4 groups: Group A (control group, no radiation), B (treated low dose radiation: 50cGy), C high 300cGy), D ( combined radiation from : 50cGy first 300cGy after 6h interval). The mRNA levels HIF-1 VEGF each group...
The purpose of this study was to investigate the expression and mechanism miR-17 in gastric lym-phoma. miR-17mimics, inhibitors negative controls were transfected into human lymphoma cell line cyp6d. proliferation, invasion apoptosis cyp6d cells detected by CCK-8, Transwell TUNEL methods, respectively. clinicopathological features analyzed real-time quantitative PCR. target gene predicted targetscan 7.2, related protein Western blot. results showed that significantly higher than normal...
To investigate the diagnostic value or information feedback of tumor markers combined with 18F-FDG PET/CT computer imaging on recurrence and metastasis non-small cell lung cancer (NSCLC). From January 2013 to December 2017, 95 NSCLC patients undergoing systemic examination at center Mudanjiang Medical University had been enrolled. Typically, interval between completion treatment should be least three months. Besides, all undergone serum CEA monitoring before after imaging, 70 them received...
The aim of this study was to identify the molecular events that distinguish serrated colorectal carcinoma (SCRC) from conventional (CCRC) through differential gene expression, pathway and protein-protein interaction (PPI) network analysis. GSE4045 GSE8671 microarray datasets were downloaded Gene Expression Omnibus database. We identified genes are differentially expressed between SCRC normal colon tissues, CCRC healthy using Student's t-tests Benjamini‑Hochberg (BH) multiple testing...