A5083057726- Fermentation and Sensory Analysis
- Biochemical Analysis and Sensing Techniques
- Histone Deacetylase Inhibitors Research
- Anesthesia and Neurotoxicity Research
- Probiotics and Fermented Foods
- DNA and Nucleic Acid Chemistry
- Traumatic Brain Injury and Neurovascular Disturbances
- Advanced biosensing and bioanalysis techniques
- Lung Cancer Treatments and Mutations
- Neuroinflammation and Neurodegeneration Mechanisms
- Horticultural and Viticultural Research
- Intensive Care Unit Cognitive Disorders
- Cancer-related gene regulation
- Wnt/β-catenin signaling in development and cancer
- Pain Management and Opioid Use
- Eicosanoids and Hypertension Pharmacology
- Lipid metabolism and disorders
- Pain Mechanisms and Treatments
- Ectopic Pregnancy Diagnosis and Management
- Lung Cancer Research Studies
- Ferroptosis and cancer prognosis
- Gynecological conditions and treatments
- Ovarian cancer diagnosis and treatment
- Gut microbiota and health
- Pulmonary Hypertension Research and Treatments
University of Electronic Science and Technology of China
2020-2025
Johns Hopkins University
2025
Nanjing Medical University
2024
Central South University
2018-2022
Third Xiangya Hospital
2022
University of Hong Kong
2022
University of Hong Kong - Shenzhen Hospital
2022
Beijing Forestry University
2016-2021
Beijing Academy of Food Sciences
2021
Hunan Cancer Hospital
2020
Background and Objectives: CD276 (B7-H3) has recently emerged as a promising presumptive immune checkpoint inhibitor (ICI) potential antibody-drug conjugate (ADC) target for prostate cancer (PCa). We evaluated B7-H3 15 other clinically relevant ADC ICI targets expression at the RNA protein level across PCa continuum - hormone-sensitive, castration-resistant, neuroendocrine. Methods: CCLE data analysis western blot experiments were performed quantifying variability cell lines. Inter-...
ABSTRACT Although right ventricle (RV) dysfunction drives clinical worsening in pulmonary hypertension (PH), information about RV function has not been well integrated PH risk assessment. The gold standard for assessing and ventriculo‐arterial coupling is the construction of multi‐beat pressure–volume (PV) loops. PV loops are technically challenging to acquire feasible routine use. Therefore, we aimed map clinically available measurements emergent loop phenotypes. One hundred one patients...
Diabetes patients with painful diabetic neuropathy (PDN) show severe spinal atrophy, suggesting pathological changes of the cord contributes to central sensitization. However, cellular and underlying molecular mechanisms within are less clear. By using a rat model type 1 diabetes (T1D), we noted an extensive irreversible astrocyte degeneration at early stage T1D, which is highly associated chronification PDN. Molecularly, acetylation astrocytic signal transducer activator transcription-3...
Summary Amino acids, biogenic amines and ammonium ion are the primary nitrogen sources in fruit wines. Compared to grape wines, our knowledge their profile wines made of other fruits is very lack. Fourteen nine kinds together with seven were selected compare component profile. White possessed highest level total amino followed by red then fruits. Red contained amines, white Ammonium was also found be higher grapes. Principal analysis revealed that obvious separations existed among from...
Benzo(a)pyrene (BaP) is a polycyclic aromatic hydrocarbon that specifically causes cancer and widely distributed in the environment. Poly (ADP-ribosylation), as key post-translational modification BaP-induced carcinogenesis, mainly catalyzed by poly (ADP-ribose) glycohydrolase (PARG) eukaryotic organisms. Previously, it found PARG silencing can counteract carcinogenesis vitro, but mechanism remained unclear. In this study, we further examined process vivo using heterozygous knockout mice...
Abstract Background: Ovarian cancer (OV) is a serious threat to women’s health. Immunotherapy new approach. Alternative splicing (AS) of messenger RNA (mRNA) and its regulation are highly relevant for understanding every hallmark may offer broadened target space. Methods: We downloaded the clinical information mRNA expression profiles 587 tumor tissues from The Cancer Genome Atlas (TCGA) database. constructed risk score model predict prognosis OV patients. association between AS-based...
The physicochemical index and the composition of amino acids six pomegranate cultivars from two regions in China were analyzed compared this study. Results showed that levels titratable acid reducing sugar found higher Xinjiang juices, while those Shandong contained more total acids. Regarding individual acids, glutamate-related, aspartate-related, pyruvate-related, serine-related aromatic contents although they not as comparable other Cluster analysis revealed could be clearly separated...
Neuroprotection strategies after cardiac arrest (CA)/cardiopulmonary resuscitation (CPR) remain key areas of basic and clinical research. This study was designed to investigate the neuroprotective effects dexmedetomidine following potential mechanisms.Anesthetized rats underwent 6-min asphyxia-based resuscitation, which experimental group received a single intravenous dose (25 μg/kg). Neurological outcomes ataxia were assessed return spontaneous circulation. The serum levels brain expression...
The aim of this study was to identify the molecular events that distinguish serrated colorectal carcinoma (SCRC) from conventional (CCRC) through differential gene expression, pathway and protein-protein interaction (PPI) network analysis. GSE4045 GSE8671 microarray datasets were downloaded Gene Expression Omnibus database. We identified genes are differentially expressed between SCRC normal colon tissues, CCRC healthy using Student's t-tests Benjamini‑Hochberg (BH) multiple testing...
The incidence of infertility is increasing, more than 30% them having related abnormal tubal patency. Four-dimensional (4D) hysterosalpingo-contrast sonography (HyCoSy) overcomes the shortcomings 3D HyCoSy in diagnosis patency, showing high specificity and accuracy. In addition, 4D discards iodine allergy X-ray radiation possesses easy-operating, contributing to good acceptance clinical practice. However, there no research explore imaging standards possibility natural pregnancy after HyCoSy....
Quality changes to bog bilberry juice at different pH levels (pH 2.67 and 3.60) during a 14-day Lactobacillus plantarum (L. B7 L. C8-1) inoculation process was investigated in terms of reducing sugars, amino acids, biogenic amines, total anthocyanins, phenolic content, color. Results showed that bacterial strains grew better the adjusted 3.60), less able utilize sugar than C8-1 both conditions entire process. Most acids amines decreased this level, while γ-aminobutyric acid increased after...
Gut microbiome affects multiple facets of human health and is inextricably linked to tumorigenesis. Substantial research has aimed understand how gut functions in the homeostasis our body. This review explores evidence demonstrating may affect body health, thereby having an impact on metabolism, protection, nutrition some anatomical-functional relationship. Alterations microbiota composition have been associated with plenty disorders. Of interest, majority researches demonstrate role cancer....