A5100730907- PI3K/AKT/mTOR signaling in cancer
- Cancer Immunotherapy and Biomarkers
- Peptidase Inhibition and Analysis
- Antibiotic Resistance in Bacteria
- Anorectal Disease Treatments and Outcomes
- Radiomics and Machine Learning in Medical Imaging
- Protein Kinase Regulation and GTPase Signaling
- Salmonella and Campylobacter epidemiology
- Lung Cancer Treatments and Mutations
- Acute Ischemic Stroke Management
- Mosquito-borne diseases and control
- Diverticular Disease and Complications
- Fungal and yeast genetics research
- Lung Cancer Diagnosis and Treatment
- IL-33, ST2, and ILC Pathways
- Protein Tyrosine Phosphatases
- Malaria Research and Control
- Chemical Synthesis and Analysis
- Signaling Pathways in Disease
- Ubiquitin and proteasome pathways
- Biochemical and Molecular Research
- Insect Resistance and Genetics
- Neuroinflammation and Neurodegeneration Mechanisms
- Pelvic floor disorders treatments
- Amoebic Infections and Treatments
Shandong First Medical University
2024-2025
Shandong Tumor Hospital
2024-2025
Shandong University
2025
Shanghai University of Traditional Chinese Medicine
2024-2025
Johns Hopkins University
2025
Emory University
2009-2024
Winship Cancer Institute
2010-2024
Longhua Hospital Shanghai University of Traditional Chinese Medicine
2024
First People's Hospital of Yunnan Province
2020-2023
Hebei University of Chinese Medicine
2022-2023
The small molecule 4EGI-1 was identified as an inhibitor of cap-dependent translation initiation owing to its disruption the eIF4E/eIF4G association through binding eIF4E. exhibits growth-inhibitory and apoptosis-inducing activity in cancer cells; thus, we were interested therapeutic efficacy human lung cells. 4EGI-1, a single agent, inhibited growth induced apoptosis cells.When combined with death ligand tumor necrosis factor-related (TRAIL), enhanced apoptosis-induced observed. As...
Intrauterine infection (chorioamnionitis) aggravates neonatal hypoxic–ischemic (HI) brain injury, but the mechanisms linking systemic inflammation to CNS damage remain uncertain. Here we report evidence for influx of T-helper 17 (T H 17)-like lymphocytes coordinate neuroinflammatory responses in lipopolysaccharide (LPS)-sensitized HI injury neonates. We found that both infants with histological chorioamnionitis and rat pups challenged by LPS/HI have elevated expression interleukin-23 (IL-23)...
This study aimed to develop a computed tomography (CT)-based radiomics model capable of precisely predicting hyperprogression and pseudoprogression (PP) in patients with non-small cell lung cancer (NSCLC) treated immunotherapy. We retrospectively analyzed 105 NSCLC, from three institutions, immune checkpoint inhibitors (ICIs) categorized them into training independent testing set. Subsequently, we processed CT scans series image-preprocessing techniques, 6008 radiomic features capturing...
The eukaryotic translation initiation factor 4E (eIF4E) is frequently overexpressed in human cancers and associated with cellular transformation, tumorigenesis, metastatic progression. It known that Mnks can phosphorylate eIF4E. Protein phosphatase 2A (PP2A) functions as a tumor suppressor, it was previously suggested to regulate eIF4E phosphorylation. However, how PP2A regulates phosphorylation has not been fully addressed. In this study, we have only validated the role of regulation but...
The phosphoinositide 3-kinase (PI3K)-mammalian target of rapamycin (mTOR) signaling axis has emerged as a novel for cancer therapy. Agents that inhibit PI3K, mTOR or both are currently under development. allosteric inhibitor, RAD001, and the PI3K/mTOR dual kinase BEZ235, examples these agents. We were interested in developing strategies to enhance mTOR-targeted caner In this study, we found BEZ235 alone effectively inhibited growth rapamycin-resistant cells. Interestingly, combination...
Eukaryotic translation initiation factor 4E (eIF4E) is the rate-limiting for cap-dependent initiation, which known to regulate oncogenesis. Elevated eIF4E and its negative impact on prognosis in human non-small cell lung cancer (NSCLC) have been reported previously. However, potential as a therapeutic target role regulation of sensitivity EGFR inhibitors an area ongoing investigations. In this study, we detected increased levels 16 NSCLC lines compared with their normal bronchial epithelial...
The mechanisms underlying rapamycin-induced Akt phosphorylation have not been fully elucidated.Inhibition of PP2A or DNA-PK attenuates abrogates and co-inhibition mTOR enhances anticancer activity.PP2A-dependent DNA-PK-mediated mechanism is involved in phosphorylation.A previously unknown a novel strategy to enhance mTOR-targeted cancer therapy may be suggested. Inhibition mammalian target rapamycin complex 1 (mTORC1), for example with rapamycin, increases while inhibiting mTORC1 signaling....
Background and Purpose— Hypoperfusion-induced thrombosis is an important mechanism for postsurgery stroke cognitive decline, but there are no perioperative neuroprotectants to date. This study investigated whether prophylactic application of Edaravone, a free radical scavenger already used in treating ischemic Japan, can prevent infarct deficits murine model transient cerebral hypoxia-ischemia. Methods— Adult male C57BL/6 mice were subjected hypoxic-ischemic (tHI) insult that consists...
Introduction The variability and unpredictability of immune checkpoint inhibitors (ICIs) in treating brain metastases (BMs) patients with advanced non-small cell lung cancer (NSCLC) is the main concern. We assessed utility novel imaging biomarkers (radiomics) for discerning NSCLC BMs who would derive advantages from ICIs treatment. Methods Data clinical outcomes pretreatment magnetic resonance images (MRI) were collected on treated between June 2019 2022 divided into training test sets....
Edaravone, a potent antioxidant, may improve thrombolytic therapy because it benefits ischemic stroke patients on its own and mitigates adverse effects of tissue plasminogen activator (tPA) in preclinical models. However, whether the combined tPA-edaravone is more effective reducing infarct size than singular treatment uncertain. Here we investigated this issue using transient hypoxia-ischemia (tHI)-induced thrombotic model, which adult C57BL/6 mice were subjected to reversible ligation...
Abstract Clinical management of neonatal hypoxic-ischemic encephalopathy (HIE) suffers from the lack reliable surrogate marker tests. Proteomic analysis may identify such biomarkers in blood, but there has been no proof-of-principle evidence to support this approach. Here we performed in-gel trypsin digestion plasma proteins four groups 10-d-old mice [untouched and 24 h after low-dose lipopolysaccharide (LPS) exposure, hypoxia-ischemia (HI), or LPS/HI injury; n = 3 each group) followed by...
<title>Abstract</title> Objective: To explore the practical application effect of MRI 3D reconstruction technology anal fistula in anorectal teaching. Methods: 30 doctors who received standardized resident training department Longhua Hospital affiliated to Shanghai University Traditional Chinese Medicine from January June 2024 were selected as research subjects. According order entry, randomly divided into control group and 3 D group, 15 physicians each group. The read only two-dimensional...
The standard therapy for locally unresectable advanced non-small cell lung cancer (NSCLC) is comprised of chemoradiotherapy (CRT) before immunotherapy (IO) consolidation. However, how to predict treatment outcomes and recognize patients that will benefit from IO remain unclear. This study aimed identify prognostic biomarkers by integrating computed tomography (CT)-based radiomics genomics. Specifically, our research involved 165 suffering Stage III NSCLC. Cohort 1 (IO following CRT) was...
ABSTRACT Although right ventricle (RV) dysfunction drives clinical worsening in pulmonary hypertension (PH), information about RV function has not been well integrated PH risk assessment. The gold standard for assessing and ventriculo‐arterial coupling is the construction of multi‐beat pressure–volume (PV) loops. PV loops are technically challenging to acquire feasible routine use. Therefore, we aimed map clinically available measurements emergent loop phenotypes. One hundred one patients...
ABSTRACT Protein phosphatase 2A (PP2A) catalytic subunit can be covalently modified at its carboxy terminus by phosphorylation or carboxymethylation. Determining the effects of these covalent modifications on relative amounts and functions different PP2A heterotrimers is essential to understanding how regulate PP2A-controlled cellular processes. In this study we have validated used a novel in vivo assay for assessing heterotrimer formation Saccharomyces cerevisiae : measurement...
Abstract Background Between 2011 and 2018, an estimated 134.8 million pyrethroid-treated long-lasting insecticidal nets (LLINs) were distributed nationwide in the Democratic Republic of Congo (DRC) for malaria control. Pyrethroid resistance has developed DRC recent years, but intensity impact on LLIN efficacy was not known. Therefore, Anopheles gambiae sensu lato (s.l.) to permethrin deltamethrin monitored before after a mass distribution LLINs Kinshasa December 2016, 6 other sites across...
Coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2, has spread globally, affecting people’s lives worldwide and hindering global development. Traditional Chinese Medicine (TCM) plays a unique role in preventing treating COVID-19. Representative prescriptions for the COVID-19 treatment, Lianhua Qingwen (LHQW) Qingfei Paidu Decoction (QFPD), effectively alleviate symptoms, delaying its progression occurrence. Despite extensive similarity their therapeutic effects, mechanisms advantages...
Asthma is a common, complex disease with apparent genetic predispositions, and previous genome-wide association studies suggest that rs1295686 within the IL13 (IL-13) gene significantly associated asthma. Analysis of data provided by 1,000 Genomes Project indicated an additional four SNPs in nearly complete linkage disequilibrium White people. However, causal mechanism remain unclear. To investigate this issue, functional genomics approaches were utilized to analyze functions these SNPs....
The adenovirus early region 4 open reading frame (E4orf4) protein specifically induces p53-independent cell death of transformed but not normal human cells, suggesting that elucidation its mechanism may provide important new avenues for cancer therapy. Wild-type E4orf4 and mutants retain toxicity also induce growth inhibition in Saccharomyces cerevisiae, which provides a genetically tractable system studying function. Interaction with the phosphatase 2A (PP2A) B regulatory subunit is...