A5078813877- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Ferroptosis and cancer prognosis
- Tracheal and airway disorders
- Esophageal and GI Pathology
- Bladder and Urothelial Cancer Treatments
- Cancer Immunotherapy and Biomarkers
- Colorectal Cancer Surgical Treatments
- Cancer-related gene regulation
- Trauma Management and Diagnosis
- Colorectal Cancer Treatments and Studies
- Pancreatic and Hepatic Oncology Research
- Hepatocellular Carcinoma Treatment and Prognosis
- Genetic factors in colorectal cancer
- Lung Cancer Research Studies
- Neuroendocrine Tumor Research Advances
- Colorectal and Anal Carcinomas
- Cancer Mechanisms and Therapy
- Autophagy in Disease and Therapy
- Urinary and Genital Oncology Studies
- Immune cells in cancer
- Cancer Research and Treatments
- X-ray Diffraction in Crystallography
- Colorectal Cancer Screening and Detection
Guangzhou University of Chinese Medicine
2022-2025
Sichuan University
2019-2024
West China Medical Center of Sichuan University
2019-2024
Third Hospital of Hebei Medical University
2022-2024
Hebei Medical University
2022-2024
Nanchang University
2017-2024
Yan'an University
2023
Air Force Medical University
2023
Jinan University
2012-2023
Sun Yat-sen University
2016-2023
EMT is an important biological process in the mechanism of tumor invasion and metastasis. However, there are still many unknowns about specific tumor. At present, a comprehensive analysis EMT-related genes colorectal cancer (CRC) lacking.All data were downloaded from public databases including TCGA database (488 samples 52 normal samples) as training set GEO (GSE40967 566 19 samples, GSE12945 62 GSE17536 177 GSE17537 55 validation sets. One hundred sixty-six (EMT-RDGs) selected Molecular...
Background Colony-stimulating factor 1 receptor (CSF1R), a classic tyrosine kinase receptor, has been identified as proto-oncogene in multiple cancers. The CSF1/CSF1R axis is essential for the survival and differentiation of M2-phenotype tumor-associated macrophages (M2 TAMs). However, we found here that CSF1R expression was abnormally down-regulated colorectal cancer (CRC), its biological functions underlying mechanisms have become elusive CRC progression. Methods class III kinases normal...
Two new Securinega alkaloids, virosaines A (1) and B (2), were isolated from the twigs leaves of Flueggea virosa. The structures absolute configurations elucidated by means NMR, X-ray diffraction, CD analyses. Compounds 1 2 represent first examples alkaloids bearing a 7-oxa-1-azabicyclo[3.2.1]octane ring system, whose plausible biogenetic pathways also proposed.
Abstract Background In the CELESTIAL trial for patients with advanced hepatocellular carcinoma (HCC), cabozantinib showed improved survival compared placebo but comes at a price. We aimed to investigate cost‐effectiveness of sorafenib‐resistant HCC from payer’s perspective USA, UK and China. Methods developed Markov models simulate pre‐treated first‐line sorafenib following trial. Quality‐adjusted life‐years (QALYs) incremental ratio (ICER) were calculated treatment or best supportive care....
Abstract Background N6‐methyladenosine (m6A) modification is an emerging epigenetic regulatory mechanism in tumourigenesis. Considering that AlkB homolog 5 (ALKBH5) a well‐described m6A demethylase previous enzyme assays, we aimed to investigate the role of methylation alteration conferred by disturbed ALKBH5 colorectal cancer (CRC) development. Methods Expression and its correlation with clinicopathological characteristics CRC were evaluated using prospectively maintained institutional...
Immunotherapy is beneficial for some colorectal cancer (CRC) patients, but immunosuppressive networks limit its effectiveness. Cancer-associatedfibroblasts (CAFs) are significant in immune escape and resistance toimmunotherapy, emphasizing the urgent need new treatment strategies. Flow cytometric, Western blotting, proteomics analysis, analysis of public database data, genetically modified cell line models, T coculture, crystal violetstaining, ELISA, metabonomic clinical tumour samples were...
// Li-Juan Deng 1, * , Qun-Long Peng Long-Hai Wang 1 Jun Xu Jun-Shan Liu 2 Ying-Jie Li Zhen-Jian Zhuo Liang-Liang Bai Li-Ping Hu Wei-Min Chen Wen-Cai Ye Dong-Mei Zhang Guangdong Province Key Laboratory of Pharmacodynamic Constituents TCM and New Drugs Research, College Pharmacy, Jinan University, Guangzhou 510632, P.R. China School Traditional Chinese Medicine, Southern Medical These authors have contributed equally to this work Correspondence to: Zhang, e-mail: dmzhang701@foxmail.com Ye,...
Abstract Background The current risk stratification system defined by clinicopathological features does not identify the of recurrence in early-stage (stage I-II) colorectal cancer (CRC) with sufficient accuracy. We aimed to investigate whether DNA methylation could serve as a novel biomarker for predicting prognosis CRC patients. Methods analyzed genome-wide status CpG loci using Infinium MethylationEPIC array run on primary tumor tissues and normal mucosa patients potential markers...
BACKGROUNDCarcinoembryonic antigen (CEA) is a commonly used biomarker in colorectal cancer.However, controversy exists regarding the insufficient prognostic value of preoperative serum CEA alone rectal cancer.Here, we combined and maximum tumor diameter to correct level, which may better reflect malignancy cancer. AIMTo assess impact CEA/tumor size METHODSWe retrospectively reviewed 696 stage I III cancer patients who underwent curative resection from 2007 2012.These were randomly divided...
Diabetic foot ulcer (DFU) is a highly morbid complication in patients with diabetes mellitus, necessitating the development of innovative pharmaceuticals to address unmet medical needs. Sodium ion (Na
Two unusual triterpenes, ilelic acids A (1) and B (2), together with their biosynthetic related compounds C (3) D (4) were isolated from the leaves of Ilex latifolia. Their structures absolute configurations elucidated by spectroscopic analysis modified Mosher's method. The plausible biogenetic pathway 1 2 is proposed. These triterpenes exhibited a potent inhibitory effect on MCF-7 MDA-MB-231 cells.
Abstract Background Neurotrophic tropomyosin receptor kinases ( NTRKs ) are a gene family function as oncogene or tumor suppressor in distinct cancers. We aimed to investigate the methylation and expression profiles prognostic value of colorectal cancer (CRC). Methods An analysis DNA CRC patients was performed explore critical methylations within genes. The marker validated retrospectively collected cohort 229 tested other types from TCGA. status determined by quantitative...
DNA methylation contributes to malignant transformation, but little is known about how the drives colorectal cancer evolution at early stages. Here we identify aberrant INA (α-internexin) gene in colon adenoma and adenocarcinoma by filtering data obtained from a genome-wide screen of methylated genes. The encoding INA, type IV intermediate filament, was frequently hypermethylated CpG islands located promoter region. This hypermethylation preferentially occurred large tumors prognostic marker...