A5101189429- Lung Cancer Treatments and Mutations
- Cancer Immunotherapy and Biomarkers
- Ferroptosis and cancer prognosis
- Pancreatic and Hepatic Oncology Research
- Lung Cancer Research Studies
- Economic and Financial Impacts of Cancer
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer-related molecular mechanisms research
- Colorectal Cancer Treatments and Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer Genomics and Diagnostics
- Neuroendocrine Tumor Research Advances
- RNA modifications and cancer
- Gastric Cancer Management and Outcomes
- Inflammasome and immune disorders
- Renal cell carcinoma treatment
- Cancer Mechanisms and Therapy
- Autophagy in Disease and Therapy
- Gastrointestinal Tumor Research and Treatment
- Immunotherapy and Immune Responses
- Cancer, Lipids, and Metabolism
- CAR-T cell therapy research
- Liver physiology and pathology
- TGF-β signaling in diseases
- Estrogen and related hormone effects
Sichuan University
2016-2025
Sichuan Cancer Hospital
2024
Mayo Clinic in Florida
2020-2023
West China Hospital of Sichuan University
2021-2023
Jacksonville College
2020-2023
West China Medical Center of Sichuan University
2018-2021
WinnMed
2020-2021
Huazhong Agricultural University
2016
Abstract Background & Aims In patients with unresectable hepatocellular carcinoma (HCC), the combination of atezolizumab and bevacizumab improved progression‐free survival (PFS) overall compared sorafenib in IMbrave150 trial. However, whether price could be affordable is unknown. The current study assessed cost‐effectiveness as first‐line systemic therapy for HCC from Chinese American payers' perspective. Methods A Markov model was built based on a global, multicentre, open‐label, phase...
EMT is an important biological process in the mechanism of tumor invasion and metastasis. However, there are still many unknowns about specific tumor. At present, a comprehensive analysis EMT-related genes colorectal cancer (CRC) lacking.All data were downloaded from public databases including TCGA database (488 samples 52 normal samples) as training set GEO (GSE40967 566 19 samples, GSE12945 62 GSE17536 177 GSE17537 55 validation sets. One hundred sixty-six (EMT-RDGs) selected Molecular...
Lung adenocarcinoma is a molecularly heterogeneous disease. Several studies, including The Cancer Genome Atlas Research Network (TCGA) and Mutation Consortium (LCMC), explored the genetic alterations among different ethnic groups. However, minority groups are often under-represented in these relevant studies genomic racial not fully understood.We analyze characteristics to understand diversities their impact on clinical outcomes.Native Americans had significantly higher rates of insertions...
Pleural and peritoneal metastasis accompanied by malignant pleural effusion (MPE) or ascites (MA) is frequent in patients with advanced solid tumors that originate from the lung, breast, gastrointestinal tract ovary. Regional delivery of CAR-T cells represents a new strategy to control tumor dissemination serous cavities. However, effusions constitute an immune-suppressive environment potentially induces cell dysfunction. Here, we demonstrated anti-tumor cytotoxicity conventional...
Poor intratumoral infiltration is the major challenge for chimeric antigen receptor (CAR)-T cell therapy in solid tumors. Hypofractionated radiotherapy (HFRT) has been reported to induce immune and reshape tumor microenvironment. Here, we showed that HFRT (5 × 5 Gy) mediated an early accumulation of myeloid-derived suppressor cells (MDSCs) decreased T microenvironment (TME) immunocompetent mice bearing triple-negative breast cancer (TNBC) or colon cancer, which was further confirmed tumors...
<h3>Importance</h3> It has been established that disparities in race and socioeconomic status are associated with outcomes of non–small cell lung cancer. However, it remains unknown whether this extends to stage I, II, or III small cancer (SCLC), limited-stage SCLC (L-SCLC). <h3>Objective</h3> To investigate the associations race, factors, treatment characteristics survival among patients L-SCLC. <h3>Design, Setting, Participants</h3> Demographic information for L-SCLC diagnosed between 2004...
Background Ovarian cancer (OC), a highly lethal in women, has 48% 5-year overall survival rate. Prior studies link the presence of IL-17 and Th17 T cells tumor microenvironment to improved OC patients. To determine if Th17-inducing vaccines are therapeutically effective OC, we created murine model dendritic cell (DC) (Th17-DC) vaccination generated by stimulating IL-15 while blocking p38 MAPK bone marrow-derived DCs, followed antigen pulsing. Methods ID8 were injected intraperitoneally into...
The non-apoptotic cell death processes including pyroptosis and ferroptosis have been implicated in the progression therapeutic responses of pancreatic adenocarcinoma (PAAD). However, extent to which influence tumor biology remains ambiguous, especially PAAD, is characterized with "cold" immunity. Considering heterogeneity among different patients, it was more practical quantify distinct profiles an individual sample. Herein, we developed a pyroptosis-ferroptosis (P-F) score for PAAD...
Hepatocellular carcinoma (HCC) is one of the leading causes cancer-related death all over world, and brings a heavy social economic burden especially in China. Several immuno-combination therapies have shown promising efficacy first-line treatment unresectable HCC are widely used clinical practice. Nevertheless, which combination most affordable unknown. Our study assessed cost-effectiveness immuno-combinations as for patients with from perspective Chinese payers.
Compared with fluorouracil, leucovorin, and oxaliplatin (FOLFOX-4) alone, cetuximab plus FOLFOX-4 has shown superior performance in terms of efficacy tolerability patients RAS wide-type (wt) metastatic colorectal cancer (mCRC) the TAILOR trial (Trial No.: EMR62202-057; ClinicalTrials.gov identifier: NCT01228734). Thus, we aimed to explore cost-effectiveness these two first-line regimens wt mCRC from Chinese societal perspective.For sake executing analysis, used a Markov model containing...
Cholangiocarcinoma (CCA) is an aggressive disease with limited treatment options. Despite substantial efforts to explore better regimens, gemcitabine-based chemotherapy has been the standard first-line for decades. With growing field of precision medicine, biomarker-guided treatments are gaining popularity. MET alteration a frequent occurrence in various cancer types, making it promising target.A 53-year-old man visited our hospital complaint upper abdominal pain. Advanced CCA was diagnosed...
The effectiveness of gemcitabine plus capecitabine compared with monotherapy for resected pancreatic cancer has been evaluated in the ESPAC-4 trial. We aimed to assess cost-effectiveness these adjuvant regimens on cancer.
Cellular autophagy plays an important role in the occurrence and development of colorectal cancer (CRC). Whether autophagy-related genes lncRNAs can be used as ideal markers CRC is still controversial. The purpose this study to identify novel treatment prognosis CRC. We downloaded transcription clinical data from GEO (GSE40967, GSE12954, GSE17536) TCGA database, screened for differentially (DEAGs) lncRNAs, constructed prognostic model, analyzed its relationship with immune infiltration....