A5020465034- Lung Cancer Treatments and Mutations
- Cancer-related molecular mechanisms research
- Cancer Genomics and Diagnostics
- Genetic factors in colorectal cancer
- Genomics and Chromatin Dynamics
- Lung Cancer Diagnosis and Treatment
- Colorectal Cancer Treatments and Studies
- Peroxisome Proliferator-Activated Receptors
- Wheat and Barley Genetics and Pathology
- Cancer Research and Treatments
- Mycobacterium research and diagnosis
- Advanced Breast Cancer Therapies
- Genomic variations and chromosomal abnormalities
- CAR-T cell therapy research
- Sexual Differentiation and Disorders
- Lung Cancer Research Studies
- MicroRNA in disease regulation
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Osteoarthritis Treatment and Mechanisms
- Genetic Mapping and Diversity in Plants and Animals
- Machine Learning in Bioinformatics
- Plant Disease Resistance and Genetics
- Acute Myeloid Leukemia Research
- Neuroblastoma Research and Treatments
- Cancer Mechanisms and Therapy
Sichuan University
2016-2025
Sichuan Agricultural University
2025
Xinqiao Hospital
2024
Army Medical University
2024
University of South China
2024
State Key Laboratory of Biotherapy
2018-2023
National Medical Products Administration
2023
Shenzhen Luohu People's Hospital
2016-2019
Shenzhen University
2019
Sunitinib is a promising drug for clinical applications; however, the efficacy reduced by feedback activation of many signaling cascades. In this study, we investigated ability (-)-epigallocatechin-3-gallate (EGCG) to synergize with sunitinib and inhibit insulin receptor substrate (IRS)/mitogen-activated protein kinase (MAPK) pathway activation. MCF-7, H460, H1975 cell lines PIK3CA mutations were treated or mock 0-24 h then pulsed 0-50 μM EGCG another 12 h; proliferation vascular endothelial...
Abstract The rhesus macaque is a prime model animal in neuroscience. A comprehensive transcriptomic and open chromatin atlas of the brain key to deeper understanding brain. Here we characterize transcriptome 416 samples from 52 regions 8 brains. We identify gene modules associated with specific like cerebral cortex, pituitary, thalamus. In addition, discover 9703 novel intergenic transcripts, including 1701 coding transcripts 2845 lncRNAs. Most are only expressed or cortical individuals....
Pleural and peritoneal metastasis accompanied by malignant pleural effusion (MPE) or ascites (MA) is frequent in patients with advanced solid tumors that originate from the lung, breast, gastrointestinal tract ovary. Regional delivery of CAR-T cells represents a new strategy to control tumor dissemination serous cavities. However, effusions constitute an immune-suppressive environment potentially induces cell dysfunction. Here, we demonstrated anti-tumor cytotoxicity conventional...
Wheat is an important cereal crop used to produce diverse and popular food worldwide because of its high grain yield (GY) protein content (GPC). However, GY GPC are usually negatively correlated. We previously reported that favorable alleles the wheat domestication gene Q can synchronously increase GPC, but underlying mechanisms remain largely unknown. In this study, we investigated regulatory network involving associated with in young grains through DNA affinity purification sequencing...
Osteoarthritis (OA) is the most common chronic joint degenerative disease. Herein, we investigated long non-coding RNA Opa-interacting protein 5-antisense transcript 1's (OIP5-AS1) in regulating mitophagy during OA.
Discrimination of multiple non-small cell lung cancers (NSCLCs) as primary (MPLCs) or intrapulmonary metastases (IPMs) is critical but remains challenging. The aim this study to develop and validate the machine learning (ML) models based on molecular features for estimating probability MPLC IPM patients presenting NSCLCs. A total 72 NSCLCs with 157 surgical resection tumor lesions from January 2012 2018 at two institutions were included developing testing models. Specifically, 46 103 tumors...
Quadruple therapy comprising 2 antibiotics, a proton pump inhibitor, and bismuth, is recommended for Helicobacter pylori eradication in China. This Phase 1, double-blind, parallel-group study aimed to evaluate the pharmacokinetics, safety, tolerability of bismuth-containing vonoprazan- or esomeprazole-based quadruple H. pylori-positive healthy subjects at single site vonoprazan 20 mg esomeprazole with bismuth potassium citrate 600 (equivalent 220 mg), clarithromycin 500 mg, amoxicillin 1000...
Abstract Background Colorectal cancer (CRC) is a major type whose mechanism of metastasis remains elusive. Methods In this study, we characterised the evolutionary pattern metastatic CRC (mCRC) by analysing bulk and single-cell exome sequencing data primary tumours from 7 patients with liver metastases. Here, were analysed whole-exome (WES); 4 these also using sequencing. Results Despite low genomic divergence between paired cancers in data, WES (scWES) revealed rare mutations defined two...
The aim of this study was to use whole genome sequencing (WGS) help detect de novo mutations or pathogenic genes Mayer-Rokitansky-Küster-Hauser syndrome type 1(MRKH 1). This a case-parent trios study. Nine unrelated probands, with MRKH 1 and their parents were enrolled. enrollment, process, establishment the detecting procedure experiment part performed over 2-year period. we detected 632 single nucleotide variants (SNVs), 267 small insertions/deletions (indels), 39 structural variations...
Thymic neuroendocrine carcinoma (NEC) is a rare type of cancer. Unlike other thymic epithelial tumors and carcinoids originating in locations, NEC possesses more aggressive biological behavior, including invasion to proximal structures, local recurrence distant hematogenous metastasis. Distant metastasis often observed the bones, lungs, spleen, liver adrenal glands. However, pancreatic resulting from extremely uncommon, only few cases patients with this disease have been reported. The...
Macaca fascicularis (M. fascicularis) is a primate model organism that played important role in studying human health. It vital to better understand the similarity and differences of gene regulation between M. human. Current comparative study two species are limited by low quality annotation lack regulatory element data on genome. In this study, we improved with 57 expression from multiple tissues and, more importantly, manual curation procedure. The new enabled us map identify location...
This study aims to investigate biological behavior changes in a murine lung cancer cell characterized by acquired resistance sunitinib, potent inhibitor of multiple-targeted receptor tyrosine kinase.A line resistant sunitinib (LL/2-R) was developed from its parental (LL/2-P). Differences characteristics and associated molecular profiles between these two cells were compared vitro vivo.LL/2-R showed an approximately 5-fold higher IC50 than LL/2-P exhibited reduced growth inhibition following...
e15000 Background: KC1036 is a novel and selective multi-kinase inhibitor that targets cell proliferation, angiogenesis, metastasis drug resistance by inhibiting receptor tyrosine kinases (AXLs VEGFRs) involved in the tumor microenvironment. has demonstrated anti-tumor activity preclinical models of solid tumors, including non-small lung cancer (NSCLC). Methods: This phase I, first-in-human study (NCT04387916) enrolled adult patients (pts) with advanced or metastatic tumors. was comprised...
For treatment of metastatic colorectal cancer, the dynamics tumor growth is an important factor for decision. However, it difficult to evaluate growth, especially those synchronous diseases. This study aimed find some indicators related proliferation judge progression. The pathological reports and clinical data 1205 patients with cancer were retrospectively reviewed; 75 known relapse time after radical resection included, expression proliferation-associated proteins was detected by...