A5079469365- CAR-T cell therapy research
- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- Monoclonal and Polyclonal Antibodies Research
- Lymphoma Diagnosis and Treatment
- T-cell and B-cell Immunology
- Neuroblastoma Research and Treatments
- Virus-based gene therapy research
- Viral Infectious Diseases and Gene Expression in Insects
- Chronic Lymphocytic Leukemia Research
- RNA Interference and Gene Delivery
- Immune cells in cancer
- Neuroendocrine Tumor Research Advances
- Immune Response and Inflammation
- Glycosylation and Glycoproteins Research
- Lung Cancer Research Studies
- Cancer therapeutics and mechanisms
- Cancer Immunotherapy and Biomarkers
- vaccines and immunoinformatics approaches
- Pancreatic and Hepatic Oncology Research
- Nanowire Synthesis and Applications
- Cancer, Hypoxia, and Metabolism
- Lung Cancer Treatments and Mutations
- Biosimilars and Bioanalytical Methods
- Pediatric Hepatobiliary Diseases and Treatments
Southwest University
2025
Sansure Biotech (China)
2025
Jacksonville College
2023-2024
Mayo Clinic in Florida
2021-2024
WinnMed
2021-2024
Guizhou Provincial People's Hospital
2024
Mayo Clinic
2024
Nemours Children's Clinic
2024
Tianjin Medical University Cancer Institute and Hospital
2024
Beijing Children’s Hospital
2011-2023
Chimeric antigen receptor T (CAR-T) cells have shown promising efficacy in treatment of hematological malignancies, but its applications solid tumors need further exploration. In this study, we investigated CAR-T therapy targeting carcino-embryonic (CEA)-positive colorectal cancer (CRC) patients with metastases to evaluate safety and efficacy. Five escalating dose levels (DLs) (1 × 105 1 108/CAR+/kg cells) were applied 10 CRC patients. Our data showed that severe adverse events related not...
A prerequisite for strong adaptive antiviral immunity is the robust initial activation of innate immune system, which frequently mediated by TLR-activated plasmacytoid DCs (pDCs). Natural antitumor often comparatively weak, potentially due to lack TLR-mediated signals within tumor microenvironment. To assess whether pDCs are capable directly facilitating effective responses, mice bearing established subcutaneous B16 melanoma tumors were administered TLR9-activated into tumor. We found that...
BAFF receptor is a target for CAR T cell therapy of B malignancies, circumventing issues with CD19 antigen loss in tumors.
FBL-3 is a highly immunogenic murine leukemia of C57BL/6 origin induced by Friend virus (MuLV). Immunization mice with readily elicits CD8+ cytotoxic T lymphocytes (CTL) capable lysing as well syngeneic leukemias Moloney and Rauscher MuLV. The aim this current study was to identify the epitope(s) recognized FBL-3-specific CTL. A series CTL clones were generated from immunized FBL-3. majority (32 38) specific for F-MuLV gag-encoded antigen. By using recombinant vaccinia viruses expressing...
Abstract Cytotoxic CD8+ T cells (CTL) are a crucial component of the immune system notable for their ability to eliminate rapidly proliferating malignant cells. However, T-cell intrinsic factors required human CTLs accomplish highly efficient antitumor cytotoxicity not well defined. By evaluating from responders versus nonresponders treatment with checkpoint inhibitors, we sought identify key associated effective CTL function. Single-cell RNA-sequencing analysis peripheral patients treated...
Lung adenocarcinoma is a molecularly heterogeneous disease. Several studies, including The Cancer Genome Atlas Research Network (TCGA) and Mutation Consortium (LCMC), explored the genetic alterations among different ethnic groups. However, minority groups are often under-represented in these relevant studies genomic racial not fully understood.We analyze characteristics to understand diversities their impact on clinical outcomes.Native Americans had significantly higher rates of insertions...
Controlled modulation of T-cell response during immunotherapy, especially the balance between T helper 1 (Th1) and Th2 responses, is critical for generating effective immune response. Here we report that dual delivery interleukin 10 (IL-10)-targeted small interfering RNA (siRNA) DNA vaccines to dendritic cells (DCs), using a single particle carrier, efficiently enhances modulates it toward stronger Th1 phenotype. Surface-functionalized polymer microparticles (MPs) carrying both...
Abstract Ag activation of the BCR may play a role in pathogenesis human follicular lymphoma (FL) and other B cell malignancies. However, nature Ag(s) recognized by tumor BCRs has not been well studied. In this study, we used unbiased approaches to demonstrate that 42 (19.35%) 217 tested FL Igs vimentin as shared autoantigen. The epitope was localized N-terminal region for all vimentin-reactive Igs. We confirmed specific binding using recombinant performing competitive inhibition studies....
Abstract Lymphomas with central nervous system (CNS) involvement confer a worse prognosis than those without CNS involvement, and patients currently have limited treatment options. T cells genetically engineered CD19-targeted chimeric antigen receptors (CAR) are effective against B-cell malignancies show tremendous potential in the of systemic lymphoma. We aimed to leverage this strategy toward more therapy for lymphoma disease. NOD-scid IL2Rgammanull (NSG) mice and/or were treated CD19-CAR...