A5045255016- Epilepsy research and treatment
- EEG and Brain-Computer Interfaces
- Neuroscience and Neuropharmacology Research
- Pharmacological Effects and Toxicity Studies
- Glioma Diagnosis and Treatment
- Neurological disorders and treatments
- Functional Brain Connectivity Studies
- Autoimmune Neurological Disorders and Treatments
- Neuroscience and Neural Engineering
- Neonatal and fetal brain pathology
- Meningioma and schwannoma management
- Vagus Nerve Stimulation Research
- Peripheral Neuropathies and Disorders
- Advanced MRI Techniques and Applications
- Anesthesia and Sedative Agents
- Treatment of Major Depression
- Neurological and metabolic disorders
- Multiple Sclerosis Research Studies
- Tryptophan and brain disorders
- Cardiovascular Syncope and Autonomic Disorders
- Ion channel regulation and function
- Vascular Malformations Diagnosis and Treatment
- Psychosomatic Disorders and Their Treatments
- Infectious Encephalopathies and Encephalitis
- Genomics and Rare Diseases
Mayo Clinic in Florida
2016-2025
WinnMed
2015-2025
Jacksonville University
2020-2024
Jacksonville College
2018-2024
Mayo Clinic in Arizona
2016-2024
Mayo Clinic
2015-2024
Nemours Children's Health System
2024
Western University
2024
Kosair Children's Hospital
2023
Neurological Surgery
2018-2022
Objective: Clinical and preclinical evidence suggests a hyperactive glutamatergic system in clinical depression. Recently, the metabotropic glutamate receptor 5 (mGluR5) has been proposed as an attractive target for novel therapeutic approaches to The goal of this study was compare mGluR5 binding (in positron emission tomography [PET] study) protein expression postmortem between individuals with major depressive disorder psychiatrically healthy comparison subjects. Method: Images were...
Accumulating evidence suggests dysfunction of the gamma-aminobutyric acid (GABA) system in major depressive disorder (MDD). Neuroimaging studies consistently report reductions cortical GABA depressed patients. Our post-mortem analyses demonstrate a reduction density and size GABAergic interneurons dorsolateral prefrontal cortex (DLPFC) MDD. The goal this study was to test whether level glutamic decarboxylase (GAD), synthesizing enzyme, will also be reduced same region Levels GAD-65 GAD-67...
We aimed to report the pattern of usage and efficacy antiepileptic drugs (AEDs) in patients with autoimmune epilepsy (AE).We retrospectively studied Mayo Clinic's electronic medical record AE which seizures were main presenting feature. Clinical data, including demographics, seizure characteristics, type AED immunotherapy used, presence neural antibody, treatment outcomes, reviewed.The records 252 adult diagnosed encephalitis paraneoplastic disorders reviewed. Seizure was initial...
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Chimeric antigen receptor T-cell (CAR T-cell) therapy is associated with neurotoxicity, which may include acute symptomatic seizures (ASySs). Specific risk factors and short-term long-term outcomes of ASyS CAR have not been well investigated. This retrospective cohort study evaluated incidence for during therapy. We included patients treated at Mayo Clinic in Minnesota, Florida, Arizona who underwent hematologic malignancies from October 2019 to November 2023. Pretreatment demographics,...
To examine the relationship between high-frequency oscillations (HFOs) and presence of preoperative seizures, World Health Organization tumor grade, isocitrate dehydrogenase 1 (IDH1) mutational status in gliomas.We retrospectively studied intraoperative electrocorticography recorded 16 patients with brain (12 presenting seizures) who underwent awake craniotomy surgical resection September 2016 June 2017. The number distribution HFOs were determined quantified visually an automated HFO...
To perform a feasibility pilot study comparing the usefulness of EEG electrode cap versus standard scalp for acquiring emergent EEGs in emergency department, inpatient, and intensive care unit patients.Nonconvulsive status epilepticus (NCSE) is neurological diagnosed exclusively by EEG. Nonconvulsive becomes more resistant to treatment 1 hour after continued seizure activity. technologists are alerted "stat" when there immediate need an during oncall hours, yet delays inevitable....
To characterize seizure semiology and the utility of antiepileptic drug (AED) therapy in leucine-rich glioma inactivated-1 ( LGI1-Ab) autoimmune epilepsy (AE).Patients with voltage-gated potassium channel complex (VGKCc) titers higher than 0.02 nmol/L who were evaluated between May 2008 June 2016 at 3 Mayo Clinic sites (Arizona, Florida, or Minnesota) identified. We then performed a retrospective review those LGI1-Ab positive treated for seizures.A total 1,095 patients VGKCc identified,...
The 3D edge-enhancing gradient-echo (EDGE) MR imaging sequence offers superior contrast-to-noise ratio in the detection of focal cortical dysplasia. EDGE could benefit from 7T but also faces challenges such as image inhomogeneity and low acquisition efficiency. We propose an EDGE-MP2RAGE that can provide both T1-weighted contrast, simultaneously, improving data-acquisition demonstrate with optimization, images sufficient uniformity high gray-to-white matter contrast be achieved.