A5101676267- Osteoarthritis Treatment and Mechanisms
- Spine and Intervertebral Disc Pathology
- Graphene and Nanomaterials Applications
- Healthcare and Venom Research
- Vitamin D Research Studies
- Pregnancy-related medical research
- Infectious Diseases and Tuberculosis
- Medical Imaging and Analysis
- Microplastics and Plastic Pollution
- Heavy Metal Exposure and Toxicity
- Innovations in Medical Education
- Spinal Fractures and Fixation Techniques
- Monoclonal and Polyclonal Antibodies Research
- Circular RNAs in diseases
- Cancer, Hypoxia, and Metabolism
- Problem and Project Based Learning
- Orthopaedic implants and arthroplasty
- Biomedical and Engineering Education
- Cutaneous lymphoproliferative disorders research
- Immune Response and Inflammation
- Pain Mechanisms and Treatments
- biodegradable polymer synthesis and properties
- RNA Research and Splicing
- MXene and MAX Phase Materials
- Musculoskeletal pain and rehabilitation
Guangdong Medical College
2013-2025
The University of Texas MD Anderson Cancer Center
2013
This study aimed to detect and characterize microplastics in intervertebral disc investigate their effects molecular mechanism on degeneration. We collected tissues from cervical, lumbar, thoracolumbar segments used Raman spectroscopy identify microplastics. Among 80 samples, 47 contained microplastics, with polyethylene being the most prevalent type. To explore of (PE-MPs), we established a mouse model nucleus pulposus cell model. Reactive oxygen species (ROS) levels were assessed via...
Abstract Ag activation of the BCR may play a role in pathogenesis human follicular lymphoma (FL) and other B cell malignancies. However, nature Ag(s) recognized by tumor BCRs has not been well studied. In this study, we used unbiased approaches to demonstrate that 42 (19.35%) 217 tested FL Igs vimentin as shared autoantigen. The epitope was localized N-terminal region for all vimentin-reactive Igs. We confirmed specific binding using recombinant performing competitive inhibition studies....
Abstract The demands for novel and efficient therapies have gradually increased with the rising concerns of osteoporosis (OP). most popular method in promoting bone regeneration during osteoporotic conditions consists loading bioactive materials different drugs to treat bones by either process osteogenesis, or inhibiting activity osteoclasts. By analyzing single cell sequencing results, we found that divalent metal transporter 1 (DMT1) played a role OP. Based on our previous melatonin (MT)...
To explore the effect of suppressive oligodeoxynucleotide-induced dendritic cells (S-DCs) in osteoarthritis (OA) therapy.S-DCs were prepared from splenic CD11c + by vitro culture with oligodeoxynucleotide. The function and phenotypes S-DCs measured ELISA flow cytometry. innate immune signaling pathways detected western blotting non-treated DCs upon stimulation. In vivo, we employed an iodoacetate-induced OA mice model. transferred intravenous route. weight bearing was evaluated...
OBJECTIVE Nuclear factor erythroid-2 related 2 (Nrf2)/ antioxidant response element (ARE) is a novel defensive pathway involved in the oxidative and chemical stress of cells. The aim study was to explore role Nrf2 on apoptosis human disc nucleus pulpous cells induced by hydrogen peroxide (H2O2). METHODS degeneration model intervertebral established. expression interfered with using sulforaphane (SFN); for that end, three groups were established: blank group (H2O2-/SFN-), control...
Disc degeneration often leads to a highly prevalent symptom known as low back pain. Healthy nucleus pulposus tissue exhibited hypoxic environment devoid of blood vessels, while degenerated experienced deterioration and the formation new vessels. In this study, expression important genes like HIF-2α was found vary between normal cells when compared surroundings. The aim study examine how is controlled in under conditions its role angiogenic mechanisms. To assess impact gradual inhibition on...
Osteosarcoma is the most common primary malignant tumor of bone, and there are many drawbacks in current treatment methods, it necessary to explore new methods. In this study, we show that TIMP1 may play an important role development osteosarcoma, demonstrate GelMA@Ti3C2/Melatonin (Gel@Ti3C2/MT) hydrogel, which can both conduct electricity sustained-release melatonin, beneficial inhibiting metastasis invasion further up-regulate expression melatonin receptor type 1 (MT1) on basis MT1...
Objective : The aim of this study was to explore the role has_circ_0010452 in progression osteoporosis (OP) targeting miR-543, as well their functions regulating proliferation and osteogenic differentiation human bone marrow mesenchymal stem cells (hBMSCs). Methods expression levels circ_0010452 miR-543 hBMSCs at different time points were determined by quantitative Real Time-Polymerase Chain Reaction (qRT-PCR). After transfection siRNA or inhibitor hBMSCs, relative marker proteins,...