A5008978742- Statistical Methods and Inference
- Lung Cancer Treatments and Mutations
- SARS-CoV-2 and COVID-19 Research
- Cancer Genomics and Diagnostics
- Animal Virus Infections Studies
- Statistical Methods and Bayesian Inference
- Statistical Methods in Clinical Trials
- vaccines and immunoinformatics approaches
- Lung Cancer Diagnosis and Treatment
- Statistical Distribution Estimation and Applications
- Viral gastroenteritis research and epidemiology
- RNA modifications and cancer
- Homelessness and Social Issues
- Advanced Causal Inference Techniques
- Chronic Kidney Disease and Diabetes
- Dialysis and Renal Disease Management
- Adolescent and Pediatric Healthcare
- Neutropenia and Cancer Infections
- Influenza Virus Research Studies
- Gene expression and cancer classification
- Phytochemical compounds biological activities
- Coral and Marine Ecosystems Studies
- Head and Neck Cancer Studies
- Marine and coastal plant biology
- Health, Environment, Cognitive Aging
University of North Florida
2020-2025
Jacksonville University
2024
University of Florida
2024
University of North Carolina at Charlotte
2019-2024
Lung adenocarcinoma is a molecularly heterogeneous disease. Several studies, including The Cancer Genome Atlas Research Network (TCGA) and Mutation Consortium (LCMC), explored the genetic alterations among different ethnic groups. However, minority groups are often under-represented in these relevant studies genomic racial not fully understood.We analyze characteristics to understand diversities their impact on clinical outcomes.Native Americans had significantly higher rates of insertions...
ABSTRACT Based on data from a randomized, controlled vaccine efficacy trial, this article develops statistical methods for assessing (VE) to prevent COVID‐19 infections by discrete set of genetic strains SARS‐CoV‐2. Strain‐specific VE adjusting possibly time‐varying covariates is estimated using augmented inverse probability weighting address missing viral genotypes under competing risks model that allows separate baseline hazards different risk groups. Hypothesis tests are developed assess...
Abstract In the ENSEMBLE randomized, placebo-controlled phase 3 trial (NCT04505722), estimated single-dose Ad26.COV2.S vaccine efficacy (VE) was 56% against moderate to severe–critical COVID-19. SARS-CoV-2 Spike sequences were determined from 484 and 1,067 placebo recipients who acquired this set of prespecified analyses, we show that in Latin America, VE significantly lower Lambda vs. Reference non-Lambda [family-wise error rate (FWER) p < 0.05]. differed by residue match mismatch...
Significance Statement Black adults in the United States have 2–4 times higher incidence of kidney failure than White adults. Yet, reasons underlying this disparity remain poorly understood. Among 547,188 US veterans with new-onset CKD, according to a new race-free GFR equation, had 2.5-fold cumulative failure, compared veterans, any follow-up period from CKD onset. This resulted combination hazards progression and lower competing-risk death veterans. Both, turn, were largely explained by...
This study aimed to develop a deep learning model predict the risk stratification of all-cause death for older people with disability, providing guidance long-term care plans. Based on government-led insurance program in pilot city China from 2017 and followed up 2021, included 42,353 disabled adults aged over 65, 25,071 assigned training set 17,282 validation set. The administrative data (including baseline characteristics, underlying medical conditions, mortality) were collected by least...
Importance Adults experiencing homelessness in the US face numerous challenges, including management of chronic kidney disease (CKD). The extent a potentially greater risk adverse health outcomes population with CKD has not been adequately explored. Objective To evaluate association between history and end-stage (ESKD) death among veterans incident CKD. Design, Setting, Participants This retrospective cohort study was conducted January 1, 2005, December 31, 2017. included aged 18 years older...
The generalized semiparametric mixed varying-coefficient effects model for longitudinal data can accommodate a variety of link functions and flexibly different types covariate effects, including time-constant, time-varying, covariate-varying effects. time-varying are unspecified time the nonparametric possibly time-dependent exposure variable. A estimation procedure is developed that uses local linear smoothing profile weighted least squares, which requires in two yet connected domains...
Summary Deployment of the recently licensed tetravalent dengue vaccine based on a chimeric yellow fever virus, CYD-TDV, requires understanding how risk disease in recipients depends jointly host biomarker measured after vaccination (neutralization titre—neutralizing antibodies) and ‘mark’ feature failure event (the amino acid sequence distance virus to represented vaccine). The CYD14 phase 3 trial CYD-TDV neutralizing antibodies via case–cohort sampling mark events, with about third missing...
Climate change is increasing the average surface temperatures of tropical waters, creating unfavorable conditions for corals. Some species coral can physiologically acclimate to elevated temperatures, but degree which genetic variation underlies differences in this ability currently unknown. Acclimation has been hypothesized be due either alterations symbiont community or changes gene expression. The present study investigated Acropora cervicornis estimated heritability plasticity upper...
Abstract This article presents generalized semiparametric regression models for conditional cumulative incidence functions with competing risks data when covariates are missing by sampling design or happenstance. A doubly robust augmented inverse probability weighted (AIPW) complete‐case approach to estimation and inference is investigated. modifies IPW estimating equations exploiting the key features in relationship between phase‐one improve efficiency. An iterative numerical procedure...
Statistical methods are developed for analysis of clinical and virus genetics data from phase 3 randomized, placebo-controlled trials vaccines against novel coronavirus COVID-19. Vaccine efficacy (VE) a vaccine to prevent COVID-19 caused by one finitely many genetic strains SARS-CoV-2 may vary strain. The problem assessing differential VE viral can be formulated under competing risks model where the endpoint is virologically confirmed cause-of-failure infecting genotype. Strain-specific...
Abstract Statistical analysis of longitudinal data often involves modeling treatment effects on clinically relevant biomarkers since an initial event (the time origin). In some studies including preventive HIV vaccine efficacy trials, participants have measured starting at the origin, whereas others later with origin unknown. The semiparametric additive time-varying coefficient model is investigated where covariates vary nonparametrically while remain constant. Weighted profile least squares...
It is of interest to pinpoint SARS-CoV-2 sequence features defining vaccine resistance. In the ENSEMBLE randomized, placebo-controlled phase 3 trial, estimated single-dose Ad26.COV2.S efficacy (VE) was 56% against moderate severe-critical COVID-19. Spike sequences were measured from 484 and 1,067 placebo recipients who acquired COVID-19 during trial. Latin America, where diversity greatest, VE significantly lower Lambda than Reference all non-Lambda variants [family-wise error rate (FWER) p...
Surveillance with computed tomography (CT) imaging following curative treatment of stage I non-small cell lung cancer (NSCLC) is important to identify recurrence or second primary cancers (SPLC). The pattern and risks therapy optimal duration surveillance scans remain unknown. objective our study assess the development SPLC risk stratify patients NSCLC therapy.We identified 261 who received for at Mayo Clinic Florida. Data was collected on clinical demographic features including gender,...