A5101629925- IL-33, ST2, and ILC Pathways
- Asthma and respiratory diseases
- Cytokine Signaling Pathways and Interactions
- Natural product bioactivities and synthesis
- Medicinal Plant Pharmacodynamics Research
- Eosinophilic Esophagitis
- Oral Health Pathology and Treatment
- Pediatric health and respiratory diseases
- Oral microbiology and periodontitis research
- MicroRNA in disease regulation
- Genomics, phytochemicals, and oxidative stress
- Neurobiology and Insect Physiology Research
- Pancreatic function and diabetes
- Connective Tissue Growth Factor Research
- Cassava research and cyanide
- Ferroptosis and cancer prognosis
- Genetic factors in colorectal cancer
- Takotsubo Cardiomyopathy and Associated Phenomena
- Insect and Arachnid Ecology and Behavior
- Curcumin's Biomedical Applications
- Wheat and Barley Genetics and Pathology
- Bioactive Compounds and Antitumor Agents
- Apelin-related biomedical research
- Syphilis Diagnosis and Treatment
- Laser Applications in Dentistry and Medicine
Capital Medical University
2015-2024
Peking University
2024
Beijing Chao-Yang Hospital
2015-2023
Cancer Institute (WIA)
2023
Shanghai First People's Hospital
2022
Shaanxi Provincial Hospital of Traditional Chinese Medicine
2020
University of California, Los Angeles
2018
Affiliated Hospital of Chengde Medical College
2016
Qingdao University
2013
Xiaomi (China)
2013
ABSTRACT Background and objective Isolated blockade of IL‐25, IL‐33 thymic stromal lymphopoietin (TSLP) has been shown to reduce airways inflammation hyperresponsiveness in murine asthma model. The hypothesis that combined all three cytokines can accomplish this more effectively never addressed. Methods We studied a model employing sensitization challenge with ovalbumin (OVA) or saline control. To discern the effects blockade, we compared outcomes strain identical, wild‐type receptor ( St2...
In Mexico, cactus pears (Opuntia spp.) are regarded as very important plants, especially in semi-arid and arid regions where few crops can be cultivated. Historically, Mexicans have used for food, fodder cattle, medicinal purposes, cosmetics, to produce dyes, natural fences. Cactus also an component of native ecosystems. Central Mexico is considered one the main centers diversity. Approximately 200 species Opuntia recognized worldwide, 114 which occur Mexico. Because most thought susceptible...
Ginkgolide B exerts a cardioprotective function against ischemia-caused apoptosis in myocardial infarction. Here we sought out to address functional mechanism associated with microRNA-29 (miR-29). Rat cardiomyocytes (H9c2 cells) were cultured ginkgolide B-conditioned medium prior hypoxic induction. To construct miR-29-overexpressed cells, miR-29 mimic was transfected into H9c2 cells. The cells harvested for assaying survivability and by CCK-8 FITC-Annexin V staining methods. Western blot...
Abstract Fungal degradation of 6:2 fluorotelomer alcohol (6:2 FTOH, C 6 F 13 CH 2 OH) by two wood‐decaying fungal strains and six isolates from a site contaminated with per‐ polyfluoroalkyl substances (PFASs) was investigated. FTOH is increasingly being used in FTOH‐based products, previous reports on the microbial fate have focused bacteria environmental consortia. Prior to this study, one report demonstrated that biotransformation fungus, Phanerochaete chrysosporium , generated more...
It has been suggested that interleukin-33 (IL-33) plays an important role in the pathogenesis of asthma through a variety pathways, but its airways fibrosis not fully elucidated. In present study we evaluated changes expression extracellular matrix proteins (ECMs) as well metalloproteinases (MMPs) and their inhibitors (TIMPs) IL-33-induced, antigen-independent murine surrogate conventional employing per-nasal challenge mice previously sensitized to produce IgE response ovalbumin (OVA)....
The search for prognostic biomarkers indicating sensitivity to immunotherapy in lung adenocarcinoma patients has zeroed on genes the switch/sucrose non-fermentable (SWI/SNF) pathway. mutational profiles of key are not clearly defined, however, and no comparisons have been conducted whether mutations involved provide same predictive value.In this study, analysis clinical factors, tumor mutation burden (TMB), chromosomal instability, co-alterations was 4344 samples. Independent online cohorts...
The mechanisms underlying the chronic, progressive airways inflammation, remodelling and alveolar structural damage characteristic of human chronic obstructive pulmonary disease (COPD) remain unclear. In present study, we address hypothesis that these changes are at least in part mediated by respiratory epithelial alarmin (IL-33)-induced production autoantibodies against cells. Mice immunized with homologous, syngeneic lung tissue lysate along IL-33 administered directly to tract or...
Background Yangxin granules (YXC), a Chinese herbal medicine, have been confirmed to clinical benefits in the treatment of heart failure. This study examined effects and molecular mechanisms YXC doxorubicin-induced cardiotoxicity vitro. Methods H9c2 cardiomyocytes were pretreated with (5, 10, or 20 mg/mL) AKT inhibitor MK-2206 (50 nM) before doxorubicin (1 µM). Cell apoptosis, viability, inflammatory factor expression (TNF-α, IL-1β, IL-6), oxidative stress mediator levels including...
Bicyclol (BIC) is a traditional antihepatitis drug that used to treat chronic hepatitis B infections by improving liver function and reducing transaminase levels. Because the extensive use of BIC for treating injury limited its poor bioavailability, course treatment with oral lasted >6 months. This study aimed develop nano‐BIC injection improve bioavailability anti‐hepatitis efficacy. We green synthetic approach prepare BIC‐bovine serum albumin (BSA) nanoparticles (BIC‐NPs). Moderate...
Background: This study was conducted to investigate the treatment efficacies and immunological mechanisms of action dioscin in mice with chicken collagen type II-induced arthritis (CIA). Methods: The CIA randomly divided into model group (M), (D), tripterygium (T); a normal control (C) also included. Each orally administered related drugs or an equal volume solvent (group C) starting on 21st day primary immunity, after which levels T helper 17 cells (Th17), regulatory (Tregs), their factors...
Objective: We investigate the effects of bone morphogenetic protein-7 (BMP-7) on models with silica-induced and macrophage-mediated fibrosis its possible mechanisms in vitro. Methods: Rat alveolar II epithelial (RLE-6TN) cells were incubated supernatant mouse macrophage-like (RAW264.7) treated 0, 25, 50, 100 μg/mL silica. Using Western blotting, markers (surfactant proteins-C E-cadherin) mesenchymal (fibronectin (FN) viminten (Vim)) detected. After neutralizing BMP-7, progress was assessed...
Abstract Chronic obstructive pulmonary disease (COPD) is a highly prevalent chronic respiratory characterised by irreversible airways obstruction associated with inflammation and remodelling, while the pathogenesis mechanistic differences between patients remain to be fully elucidated. We previously reported that alarmin cytokine IL‐33 may contribute production of autoantibodies against epithelial cells. Here we expand hypothesis autoimmune responses induced airway microbiota also...
Objective: To assess the feasibility and prognostic value of minimal residual disease (MRD) evaluated by multiparameter flow cytometry (MFC) in newly diagnosed multiple myeloma (MM) patients China. Methods: Clinical data 106 consecutively MM with MRD were retrospectively analyzed a single center China from June 2013 to 2015. Results: ① Of patients, 48 (45.3%) achieved negativity. The median time MRD-negative was 3 months. More undergoing autologous stem cell transplantation (ASCT) negativity...