A5028886034- Drug-Induced Hepatotoxicity and Protection
- Curcumin's Biomedical Applications
- Drug Transport and Resistance Mechanisms
- Protein Interaction Studies and Fluorescence Analysis
- Liver Disease Diagnosis and Treatment
Shanghai First People's Hospital
2022-2023
Bicyclol (BIC) is a traditional antihepatitis drug that used to treat chronic hepatitis B infections by improving liver function and reducing transaminase levels. Because the extensive use of BIC for treating injury limited its poor bioavailability, course treatment with oral lasted >6 months. This study aimed develop nano‐BIC injection improve bioavailability anti‐hepatitis efficacy. We green synthetic approach prepare BIC‐bovine serum albumin (BSA) nanoparticles (BIC‐NPs). Moderate...
A simple, sensitive, and rapid LC-MS/MS method for the simultaneous determination of BIC, M7 M8 active metabolites in SD rat plasma was developed. After salting-out assisted liquid–liquid extraction (SALLE) with 5 M ammonium acetate solution, sample analyzed on a Sciences column (C18 3.0 x 100 mm, 3 μm) using gradient elution at 40℃ within 7 min. The assay displayed excellent linearity range 4-2000 ng/mL 1-500 M8. results this exhibited that precision, accuracy, matrix effect, recovery,...