A5101915911- Asthma and respiratory diseases
- IL-33, ST2, and ILC Pathways
- Eosinophilic Esophagitis
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Pediatric health and respiratory diseases
- Obstructive Sleep Apnea Research
- Allergic Rhinitis and Sensitization
- Dermatology and Skin Diseases
- interferon and immune responses
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Neonatal Respiratory Health Research
- Medical Imaging and Pathology Studies
- Ubiquitin and proteasome pathways
- Nutritional Studies and Diet
- Pregnancy-related medical research
- Venous Thromboembolism Diagnosis and Management
- Gut microbiota and health
- Viral Infections and Vectors
- Hernia repair and management
- Public Health and Nutrition
- Pelvic floor disorders treatments
Xiangya Hospital Central South University
2024
Central South University
2024
Capital Medical University
2016-2023
Guangzhou Medical University
2023
Women's Hospital, School of Medicine, Zhejiang University
2019
Central People's Hospital of Zhanjiang
2013
Zhejiang University
2006
ABSTRACT Background and objective Isolated blockade of IL‐25, IL‐33 thymic stromal lymphopoietin (TSLP) has been shown to reduce airways inflammation hyperresponsiveness in murine asthma model. The hypothesis that combined all three cytokines can accomplish this more effectively never addressed. Methods We studied a model employing sensitization challenge with ovalbumin (OVA) or saline control. To discern the effects blockade, we compared outcomes strain identical, wild‐type receptor ( St2...
The T-helper cell type 2-promoting cytokine interleukin-33 (IL-33) has been implicated in asthma pathogenesis. Angiogenesis is a feature of airways remodelling asthma. We hypothesized that IL-33 induces angiogenesis and expression angiogenic factors an established murine surrogate In the present study, BALB/c mice were subjected to serial intranasal challenge with alone for up 70 days. parallel, ovalbumin (OVA) -sensitized OVA or normal saline serve as positive negative controls,...
<b><i>Aims:</i></b> Early evaluation of pelvic floor muscle (PFM) in postpartum women is important for the treatment stress urinary incontinence (SUI). Digital vaginal palpation and electromyography (EMG) based on Glazer protocol are widely used assessment PFM. However, correlation among digital palpation, EMG, morbidity SUI still unclear. This study aims to investigate relationship between PFM examinations. <b><i>Methods:</i></b>...
Abstract Objective To explore the potential association between dietary live microbes and prevalence of Chronic Obstructive Pulmonary Diseases (COPD). Methods In this cross-sectional study, data 9791 participants aged 20 years or older in study were collected from National Health Nutrition Examination Survey (NHANES) 2013 2018. Participants classified into three groups according to Sanders’ microbe classification system: low, medium, high groups. COPD was defined by a combination...
Background Efficient therapy and potential prophylaxis are confounded by current ignorance of the pathogenesis airway remodelling blockade in COPD. Objective To explore role IL-33/ST2 axis cigarette smoke (CS) exposure-induced airways remodelling. Methods C57BL/6, BALB/c IL-1RL1 -/- mice exposed to CS were used establish an animal surrogate COPD (air-exposed=5~8, CS-exposed=6~12). Hallmarks measured mice. Cigarette extract (CSE)-induced proliferation protein production vitro fibroblasts...
It has been suggested that interleukin-33 (IL-33) plays an important role in the pathogenesis of asthma through a variety pathways, but its airways fibrosis not fully elucidated. In present study we evaluated changes expression extracellular matrix proteins (ECMs) as well metalloproteinases (MMPs) and their inhibitors (TIMPs) IL-33-induced, antigen-independent murine surrogate conventional employing per-nasal challenge mice previously sensitized to produce IgE response ovalbumin (OVA)....
Many asthmatic patients are exposed to cigarette smoke actively or passively, which contributes asthma exacerbation and poor control. This study is explore the effects of on pathological changes in murine surrogate asthma.C57BL/6 mice were sensitised challenged with ovalbumin (OVA) establish a then administered extract (CSE). Airways hyperresponsiveness (AHR) was measured using Flexivent system. Histological staining (haematoxylin-eosin [HE], periodic acid Schiff [PAS], Congo red Masson's...
<b>Introduction:</b> We previously implicated the calcium-sensing receptor (CaSR) in development of airways inflammation and hyperresponsiveness human asthma, that topical CaSR antagonists (calcilytics) reduce both animal surrogates. <b>Aim:</b> Extend these studies to alarmin-driven by comparing efficacy (intranasal) calcilytic a head-to-head comparison Th2/IgE mediated (OVA) alarmin (interleukin (IL)-33) driven asthma murine surrogate. <b>Methods:</b> IL-33 (naïve mice) or OVA (mice...
Objective To investigate the effect of Rivaroxaban on prevention from deep vein thrombosis (DVT) for sufferers with hip arthroplasty.Methods The 127 patients arthroplasty were divided randomly into group and control group.The was adopted routine mechanical prevention.Based it,the Rivaroxaban.The number cases postoperative formation two groups compared.Results There no DVT in group,but there 16 group.There significant difference between groups.Conclusions plays a remarkable role preventing...
<h3>Introduction</h3> Exposure to urban particulate matter (UPM) exacerbates the development of asthma and COPD. UPM exposure triggers release 'alarmins' by airway epithelium, which causes an inflammatory response such as acceleration activation maturation dendritic cells (DC). Previously, we have demonstrated that, in surrogate models allergic asthma, certain environmental stimuli activate calcium-sensing receptor (CaSR), drives bronchial hyperresponsiveness, inflammation remodelling. We...