A5049144598- Cancer Immunotherapy and Biomarkers
- CAR-T cell therapy research
- Immune Cell Function and Interaction
- Prostate Cancer Treatment and Research
- Immunotherapy and Immune Responses
- Chronic Lymphocytic Leukemia Research
- Molten salt chemistry and electrochemical processes
- Radiopharmaceutical Chemistry and Applications
- Prostate Cancer Diagnosis and Treatment
- Renal cell carcinoma treatment
- Lymphoma Diagnosis and Treatment
- Acute Lymphoblastic Leukemia research
- Immunodeficiency and Autoimmune Disorders
- Metallurgical Processes and Thermodynamics
- Supercapacitor Materials and Fabrication
- Fungal Biology and Applications
- Mesoporous Materials and Catalysis
- Advancements in Battery Materials
- Ocular Surface and Contact Lens
- Extraction and Separation Processes
- Polysaccharides and Plant Cell Walls
- Photonic Crystals and Applications
- Ferroptosis and cancer prognosis
- Hepatitis B Virus Studies
- RNA Interference and Gene Delivery
WinnMed
2018-2025
Mayo Clinic
2018-2025
Shandong University
2019-2025
Harbin Engineering University
2018-2024
Mayo Clinic in Arizona
2014-2024
Northwestern Polytechnical University
2024
Shenyang Agricultural University
2022-2023
King Faisal Specialist Hospital & Research Centre
2023
Shanghai Academy of Agricultural Sciences
2018-2022
First Affiliated Hospital of Jiamusi University
2022
We report a seeded-growth process that results in the adhesion of size-controlled gold (Au) nanoparticles (NPs) to surface reduced graphene oxide (rGO), leading formation rGO-Au nanocomposites. The synthesis approach involves utilization Au molecular precursors (i.e., seeds) bonded oxygen functionalities which intrinsically exist on GO. Upon reduction precursors, deposition NPs is ensured. It found size controlled via variation precursor concentration growth solution. redox chemistry between...
Abstract Cytotoxic CD8+ T cells (CTL) are a crucial component of the immune system notable for their ability to eliminate rapidly proliferating malignant cells. However, T-cell intrinsic factors required human CTLs accomplish highly efficient antitumor cytotoxicity not well defined. By evaluating from responders versus nonresponders treatment with checkpoint inhibitors, we sought identify key associated effective CTL function. Single-cell RNA-sequencing analysis peripheral patients treated...
The effective extraction of neutron poison samarium from nuclear waste to prevent reactions with metallic uranium is crucial for the sustainable development energy. electrochemical recovery on liquid gallium cathode NaCl-2CsCl molten salts has been investigated by a variety techniques, and its reduction properties kinetic parameters have provided. It was revealed that reaction Mo Ga(III) Ga(0) Sm(III) Sm(II) two-step one-step process, respectively, both are reversible. diffusion coefficients...
Management of PD-1 blockade resistance in metastatic melanoma (MM) remains challenging. Immunotherapy or chemotherapy alone provides limited benefit this setting. Chemo-immunotherapy (CIT) has demonstrated favorable efficacy and safety profiles lung cancer. Our pre-clinical study showed that MM patients who have failed blockade, the addition increases CX3CR1+ therapy-responsive CD8+ T-cells with enhanced anti-tumor activity, resulting improved clinical response. Here, we examined outcomes...
Outcomes for resistant metastatic castration-resistant prostate cancer (CRPC) are poor. Stereotactic ablative radiotherapy (SABR) induces antitumor immunity in clinical and preclinical studies, but immunologic biomarkers lacking.Eighty-nine patients with oligometastatic CRPC were identified by 11C-Choline-PET (Choline-PET) from August 2016 to December 2019 treated SABR. Prespecified coprimary endpoints 2-year overall survival (OS) PSA progression. Secondary included SABR-treated local...
The application of 2,2-dichloro-1,3-benzodioxole (DCBZ) as a versatile hydroxyl protection reagent in carbohydrate chemistry has been demonstrated. DCBZ exhibited high reactivity with diverse vicinal and remote dihydroxyl groups furanoses pyranoses to form benzodioxole (BZDO)-protected products. BZDO group showed remarkable stability under basic, redox, glycosylation conditions can be efficiently removed acid the presence diol, highlighting its utility orthogonal synthesis complex glycans.
Abstract Immune checkpoint inhibitors (ICI) are effective for advanced melanoma. However, most develop ICI resistance. Tumor-derived soluble PD-L1 (sPD-L1) and other immunosuppressive factors drive We hypothesized that therapeutic plasma exchange (TPE) may remove sPD-L1 from circulation overcome Patients with metastatic ICI-resistant melanoma elevated received radiotherapy to a minority of lesions, TPE, re-challenge. Primary endpoints were adverse events reduction. Secondary included overall...
Prostate cancer, one of the most frequently diagnosed tumors men, leads to poor quality life. Previous studies have shown that breviscapine (BRE) exerts therapeutic activity in malignant tumors. However, role and mechanism BRE exhibit an anti-tumor effect on prostate cancer are largely unknown. The mRNA protein levels tissues cell lines were measured using RT-qPCR, western blot, immunohistochemical staining, respectively. Cell proliferation, invasion, migration both PC3 DU145 cells evaluated...
Breast cancer remains a major health problem worldwide. While chemotherapy represents an important therapeutic modality against breast cancer, limitations in the clinical use of remain formidable because chemoresistance. The HER2/PI-3K/Akt pathway has been demonstrated to play causal role conferring broad chemoresistance cells and thus justified be target for enhancing effects anti-breast chemotherapies, such as adriamycin (ADR). Agents that can either enhance chemotherapeutics or overcome...
Abstract Background Acellular porcine corneal stroma (APCS) has proven to be a promising alternative traditional grafts. This prospective case series was conducted further investigate the healing characteristics of APCS following keratoplasty. Methods Twenty‐seven patients undergoing implantation treat infectious keratitis were included. The followed up for 12 months after surgery. main outcome measures included visual acuity, transparency, graft thickness, and cellular nerve regeneration....
We present a novel approach to preparing bismuth acceptor doped barium titanate nanocrystal formulations that can be deposited in conjunction with polymers order prepare thin film nanocomposite dielectric exhibits desirable capacitor characteristics. Exploring the limits of function nanocomposites is an important avenue materials research, while paying strict attention overall device quality, namely permittivity, loss and equivalent series resistance (ESR). Pushing higher frequencies, goal...
Abstract Cells respond to cytotoxic DNA double-strand breaks by recruiting repair proteins the damaged site. Phosphorylation of histone variant H2AX at S139 and Y142 modulate its interaction with downstream their recruitment lesions. Here we report ATM-dependent ZNF506 localization lesion through MDC1 following damage. ZNF506, in turn, recruits protein phosphatase EYA, resulting dephosphorylation Y142, which further facilitates other factors. Thus, regulates early dynamic signaling damage...
Self-assembled films built from nanoparticles with a high dielectric constant are attractive as foundation for new media increased efficiency and range of operation, due to the ability exploit nanofabrication techniques emergent electrical properties originating nanoscale. However, because building block is discrete one-dimensional unit, it becomes challenge capture potential enhancements in performance two or three dimensions, frequently surface effects presence discontinuities. This...