A5027253108- Catalytic C–H Functionalization Methods
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Synthesis and Catalytic Reactions
- Sulfur-Based Synthesis Techniques
- Asymmetric Hydrogenation and Catalysis
- Carbohydrate Chemistry and Synthesis
- Glycosylation and Glycoproteins Research
- Radical Photochemical Reactions
- Chemical Synthesis and Analysis
- Asymmetric Synthesis and Catalysis
- Catalytic Cross-Coupling Reactions
- Sphingolipid Metabolism and Signaling
- N-Heterocyclic Carbenes in Organic and Inorganic Chemistry
- Advanced Synthetic Organic Chemistry
- Cyclopropane Reaction Mechanisms
- Molecular Sensors and Ion Detection
- Enzyme Production and Characterization
- Photochemistry and Electron Transfer Studies
- Nanoplatforms for cancer theranostics
- Nitric Oxide and Endothelin Effects
- Synthetic Organic Chemistry Methods
- Crystallography and molecular interactions
- Electron Spin Resonance Studies
- Fluorine in Organic Chemistry
Shenzhen Polytechnic
2024-2025
Polytechnic University
2025
Bridge University
2023
Southern University of Science and Technology
2020-2022
University of Science and Technology of China
2020
Hefei National Center for Physical Sciences at Nanoscale
2020
Anhui Medical University
2019
RWTH Aachen University
2015-2018
South China Normal University
2012
An efficient kinetic resolution of sulfoximines with enals was realized using chiral N-heterocyclic carbene (NHC) catalysts. The stereoselective amidation proceeds without additional acyl transfer agent. Both enantiomers the can be obtained excellent ee values (up to 99% and −97% ee, respectively). Performing catalysis on a gram scale allowed recovered sulfoximine (+)-1j in an asymmetric synthesis FXa inhibitor F.
Abstract By means of carbon‐13 nmr (at 25 MHz) the trans/cis conformer ratio in glycyl‐ L ‐proline has been measured aqueous (D 2 O) solution over temperature range 33–96°C. It is found that Δ H 0 = −4.2 kJ/mole and S −9.7 J/mole/K. Measurements T 1 values for proline ring carbons yielded consistent with a fast puckering process involving both β‐ γ‐carbons. rate cis‐trans conformational interconversion ‐proline, using complete line‐shape analysis glycyl α‐carbon resonance, gave trans → cis...
Abstract Ball milling techniques have been applied in the development of a mechanosynthesis [Cp*Co(CO)I 2 ], which proved highly efficient as catalyst mechanochemical C−H bond amidations indoles mixer ball mill. A wide range amidated products is obtained excellent yields. Compared to solution‐based methods, procedure opens more feasible and environmentally‐friendly access both cobalt(III) 2‐amidated indoles. magnified image
A ruthenium-catalyzed arylation reaction of oxa- and azabicyclic alkenes with (hetero)arenes by C–H bond activation has been discovered. The does not require additives utilizes dioxygen in realizing the catalytic cycle leading to monosubstituted 7-oxa 7-azabenzonorbornane derivatives.
Abstract Photoinduced hydroarylation of alkenes is an appealing synthetic strategy for arene functionalization. Herein, we demonstrated that aryl radicals generated from electron‐deficient chlorides/bromides could be trapped by array terminal/internal in the presence [Pt(O^N^C^N)] under visible‐light (410 nm) irradiation, affording anti‐Markovnikov hydroarylated compounds up to 95 % yield. Besides, a protocol [Pt(O^N^C^N)]‐catalyzed intramolecular photocyclization acrylanilides give...
Abstract Gangliosides play vital biological regulatory roles and are associated with neurological system diseases, malignancies, immune deficiencies. They have received extensive attention in developing targeted drugs diagnostic markers. However, it is difficult to obtain enough structurally defined gangliosides analogs especially at an industrial-relevant scale, which prevent exploring structure-activity relationships identifying drug ingredients. Here, we report a highly modular...
Under solventless grinding conditions, mechanochemical ruthenium-catalyzed hydroarylations of alkynes with acetanilides lead to trisubstituted alkenes. Only catalytic amounts pivalic acid or copper acetate are required, and without the need for external heating, reaction times shorter than those their solution-based counterpart. Mechanochemical oxidative annulations through palladium-catalyzed intramolecular amination convert products into N-acetylindoles.
A Cp*Rh(III) complex has been used as catalyst for the preparation of unprecedented 1,2-benzothiazepine 1-oxides by [4 + 3] cyclization NH-sulfoximines with α,β-unsaturated ketones. For a wide range substrates various functional groups, moderate to good product yields were obtained.
A novel iridium-catalyzed asymmetric ring-opening (ARO) reaction of oxabenzonorbornadienes with a variety phenols was reported, which afforded the corresponding trans-2-phenoxy-1,2-dihydronaphthalen-1-ol products in high yields moderate to excellent enantioselectivities (up 98% ee) under mild conditions. The trans are formed via enantioselective cleavage bridgehead carbon–oxygen bond 1 followed by SN2 nucleophilic attack phenols. effects various bisphosphine ligands, Ag (I) salts, ammonium...
Abstract A Hofmann‐Löffler‐Freytag type cyclization reaction of S ‐aryl‐ ‐phenylpropyl sulfoximines (and related derivatives) was developed. Using molecular iodine as the initiator under visible light a series five‐membered cyclic products obtained in moderate to high yields. The approach represents new strategy for synthesis dihydroisothiazole oxides and benzo[ d ]isothiazoles‐1‐oxides. magnified image
Under an atmosphere of dioxygen, copper-catalyzed de-alkylation/amination sequences provide sulfonimidamides from unprotected sulfoximines in moderate to good yields. Mechanistic studies suggest the involvement radicals both C-S bond cleavage and formation new N-S bond.
The application of 2,2-dichloro-1,3-benzodioxole (DCBZ) as a versatile hydroxyl protection reagent in carbohydrate chemistry has been demonstrated. DCBZ exhibited high reactivity with diverse vicinal and remote dihydroxyl groups furanoses pyranoses to form benzodioxole (BZDO)-protected products. BZDO group showed remarkable stability under basic, redox, glycosylation conditions can be efficiently removed acid the presence diol, highlighting its utility orthogonal synthesis complex glycans.
An N-heterocyclic carbene (NHC)-catalyzed highly diastereo- and enantioselective formal [3+2] reaction of o-hydroxy aromatic aldimines cinnamaldehydes for the preparation enantioenriched trans-γ-lactams was developed. internal hydrogen bond between imine function crucial reactivity chemical selectivity. Trans-γ-lactam 3 d easily oxidized to multifunctional 1,4-benzoquinone 8, which could further be transformed biaryl 9 in presence a phosphoric acid. Finally, preliminary results kinetic...
An efficient synthesis of N-propargylsulfoximines was developed through a copper-catalyzed coupling aldehydes, alkynes, and NH-sulfoximines. The reaction requires no co-catalyst or ligand shows wide substrate scope with moderate to good yields.
An efficient copper-catalyzed C−H/N−H bond functionalization for the synthesis of α-keto-<i>N</i>-acyl sulfoximines from aryl methyl ketones and <i>N</i>H-sulfoximines with molecular oxygen as terminal oxidant has been developed.
The recent progress in transition metal-catalyzed ring-opening reactions of azabicyclic alkenes was reviewed focused on the influence types metal catalysts, nucleophiles, ligands, structures and its derivatives, solvents additives reactions.Moreover, possible mechanisms were also discussed.
Abstract Photoinduced hydroarylation of alkenes is an appealing synthetic strategy for arene functionalization. Herein, we demonstrated that aryl radicals generated from electron‐deficient chlorides/bromides could be trapped by array terminal/internal in the presence [Pt(O^N^C^N)] under visible‐light (410 nm) irradiation, affording anti‐Markovnikov hydroarylated compounds up to 95 % yield. Besides, a protocol [Pt(O^N^C^N)]‐catalyzed intramolecular photocyclization acrylanilides give...
A photochemical approach towards oxindoles with C3 quaternary centers by the radical cascade reaction of α,β-unsaturated N -arylacryl amides alkyl bromides or iodides upon visible light irradiation under mild conditions was developed.
Abstract The reaction has a broad substrate scope and delivers the products in moderate to high yields.
Abstract Under an atmosphere of dioxygen, copper‐catalyzed de‐alkylation/amination sequences provide sulfonimidamides from unprotected sulfoximines in moderate to good yields.
Abstract An efficient kinetic resolution of sulfoximines with enals using chiral N‐heterocyclic carbene catalysts is investigated.