A5114585302- Shoulder Injury and Treatment
- Cancer Immunotherapy and Biomarkers
- Cancer Cells and Metastasis
- Gastric Cancer Management and Outcomes
- Bioactive Compounds and Antitumor Agents
- Neuroscience and Neuropharmacology Research
- Cytokine Signaling Pathways and Interactions
- Traditional Chinese Medicine Analysis
- RNA modifications and cancer
- Neurogenesis and neuroplasticity mechanisms
- Lung Cancer Treatments and Mutations
- Bioinformatics and Genomic Networks
- Colorectal Cancer Treatments and Studies
- Osteoarthritis Treatment and Mechanisms
- Bone Metabolism and Diseases
- Epigenetics and DNA Methylation
- Ferroptosis and cancer prognosis
- MicroRNA in disease regulation
- Birth, Development, and Health
- CAR-T cell therapy research
- Berberine and alkaloids research
- Synthesis and bioactivity of alkaloids
- Redox biology and oxidative stress
- Cancer Risks and Factors
- Cancer-related molecular mechanisms research
Guangzhou University of Chinese Medicine
2023-2025
Guangdong Academy of Medical Sciences
2025
Shanghai Botanical Garden
2024
Dalian Medical University
2010-2023
Chongqing Medical University
2010-2023
Second Affiliated Hospital of Chongqing Medical University
2010-2023
Army Medical University
2018
Southwest Hospital
2018
Fuling Center Hospital of Chongqing
2016
Creative Commons
2016
Chimeric antigen receptor T (CAR-T) cells have shown promising efficacy in treatment of hematological malignancies, but its applications solid tumors need further exploration. In this study, we investigated CAR-T therapy targeting carcino-embryonic (CEA)-positive colorectal cancer (CRC) patients with metastases to evaluate safety and efficacy. Five escalating dose levels (DLs) (1 × 105 1 108/CAR+/kg cells) were applied 10 CRC patients. Our data showed that severe adverse events related not...
Exposure to stressful life events during pregnancy exerts profound effects on neurodevelopment and increases the risk for several neurodevelopmental disorders including major depression. The mechanisms underlying consequences of gestational stress are complex remain be elucidated. This study investigated depressive-like behavior epigenetic modifications in young adult offspring. Gestational was induced by a combination restraint 24-hour light disturbance pregnant dams throughout gestation....
Bacterial infections trigger a multifaceted interplay between inflammatory mediators and redox regulation. Recently, accumulating evidence has shown that signaling plays significant role in immune initiation subsequent cell functions. This review addresses the crucial of thioredoxin (Trx) system reactions regulation responses during bacterial infections. Downstream pathways various cells involve thiol-dependent regulation, highlighting pivotal roles thiol systems defense mechanisms....
Abstract: Rotator cuff injury is a disease in which the muscle and tendon that constitute rotator are torn causing shoulder pain limited function. Osteoporosis (OP) systemic metabolic bone characterized by decreased mass, destruction of microstructure, strength, increased fragility. Both common musculoskeletal diseases occur middle-aged elderly people, their prevalence gradually increases with age. Clinically, OP comorbidity very common, especially terms metabolism. In recent years, plant...
Synthetic antidepressants in current use for the complex etiopathogeneses of depression have slow response and remission as well various unpleasant side effects. As a result, it is imperative to develop new with more effectiveness less severe Recent studies demonstrated that genipin, aglycon geniposide, extracted from Gardenia jasminoides Ellis has antidepressive However, knowledge regarding molecular mechanisms its antidepressant effects remains limited. Employing depression-like mouse...
BACKGROUND Lung cancer is the most common cause of cancer-associated deaths worldwide. This study aimed to investigate efficacy and safety Traditional Chinese Medicine combining EGFR-TKIs in treatment NSCLC patients harboring EGFR mutations. MATERIAL AND METHODS involved 153 advanced-stage Patients were divided into a Control group (administered EGFR-TKI, n=61) an Experimental TKI, n=92). Progression-free survival (PFS) was evaluated for exon 19 deletion and/or 21 patients. Disease control...
Epithelial‑mesenchymal transition (EMT) is the process by which epithelial cells depolarize and acquire a mesenchymal phenotype, common early step in of metastasis. Patients with lung cancer frequently already have distant metastases when they are diagnosed, highlighting requirement for effective interventions to control metastatic disease. Transforming growth factor‑β1 (TGF‑β1) able induce EMT, however molecular mechanism this remains unclear. In current study, TGF‑β1 was reported EMT...
Squamous cell carcinoma and adenocarcinoma are the major histological types of non-small lung cancer. Because they differ on basis histopathological clinical characteristics their relationship with smoking, etiologies may be different; for example, different tumor suppressor genes related to genesis each type. We used microarray data construct three regulatory networks identify potential squamous investigated similarity specificity them. In network, some observed transcription factors target...
Objective: To investigate differentially expressed genes associated with liver cancer using bioinformatics methods, and to screen out molecular markers for early diagnosis of potential targets immunotherapy. Methods: The microarray data were downloaded from Gene Expression Omnibus. JMP software was used correlation analysis GSE datasets, Limma program in R language genes, the Ontology (GO) enrichment Kyoto Encyclopedia Genes Genome (KEGG) pathway performed genes. A protein-protein...