A5053117966- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Natural product bioactivities and synthesis
- Crystallography and molecular interactions
- Traditional and Medicinal Uses of Annonaceae
- Phytochemistry and Biological Activities
- Bioactive Compounds and Antitumor Agents
- Phytochemistry and Bioactive Compounds
- Alkaloids: synthesis and pharmacology
- Phytochemical Studies and Bioactivities
- Biological Stains and Phytochemicals
- Marine Sponges and Natural Products
- Plant-Derived Bioactive Compounds
- Plant-based Medicinal Research
- Ion Transport and Channel Regulation
- Chemical synthesis and alkaloids
- Synthesis and Biological Activity
- Bioactive Natural Diterpenoids Research
- Biological Activity of Diterpenoids and Biflavonoids
- Microbial Natural Products and Biosynthesis
- Bioactive natural compounds
- Steroid Chemistry and Biochemistry
- Plant biochemistry and biosynthesis
- Plant and Fungal Species Descriptions
- Natural Compound Pharmacology Studies
Jinan University
2015-2024
First Affiliated Hospital of Zhengzhou University
2024
Shanxi Agricultural University
2023-2024
First Hospital of Shanxi Medical University
2024
Shanxi Medical University
2024
University of South Carolina
2021
Xinjiang Academy of Agricultural and Reclamation Science
2008-2020
Shandong University of Traditional Chinese Medicine
2014-2019
University of Hong Kong
2016
Shenzhen Institute for Drug Control
2015
Hepatocellular carcinoma (HCC) is a deadly form of cancer without effective chemotherapy so far. Currently, only sorafenib, multitargeted tyrosine kinase inhibitor, slightly improves survival in HCC patients. In searching for natural anti-HCC components from toad venom, which frequently used the treatment liver traditional Chinese medicine, we discovered that arenobufagin, bufadienolide had potent antineoplastic activity against HepG2 cells as well corresponding multidrug-resistant HepG2/ADM...
Cancer is still a severe threat to the health of people worldwide. Chemotherapy one main therapeutic approaches combat cancer. However, chemotherapy only has limited success with side effects, especially causing damage normal tissues such as bone marrow, gastrointestine, heart, liver, renal, neuron, and auditory tissues, etc. The side-effects limit clinical outcome lower patients' quality life, even make many patients discontinue chemotherapy. Thus, there need explore effective adjuvant...
Five sesquiterpene-based meroterpenoids with three kinds of new skeletons [1, 2, 3, (+)-4, and (−)-4] were isolated from the leaves Myrtus communis. Compound 1 featured a carbon skeleton an unprecedented octahydrospiro[bicyclo[7.2.0]undecane-2,2′-chromene] tetracyclic ring system, which possessed two preferred conformations detected by variable-temperature NMR spectroscopy experiments. In addition, structure reported myrtucommulone K was revised to be compound 3. The plausible biosynthetic...
ClC-3 chloride (Cl–) channel has been shown to be involved in cell proliferation, cycle, and migration processes. Herein, we found that a series of bufadienolides isolated from toad venom were novel class Cl– activators with antitumor activities. Bufalin, which the most potent activity, 15β-acetyloxybufalin, no chosen as representative compounds investigate role channel. It was bufalin rapidly elicited activation subsequently induced apoptosis through inhibition PI3K/Akt/mTOR pathway. The...
Neuraminidase inhibitors (NAIs) are the mainstay antiviral drugs against influenza infection. In this study, a ligand fishing protocol was developed to screen NAIs using neuraminidase immobilized magnetic beads (NA-MB). After verifying feasibility of NA-MB with an artificial mixture including NA and non-inhibitors, applied from crude extracts Duchesnea indica Andr. Twenty-four binding compounds were identified normal butanol (n-BuOH) extract D. as potential by high-performance liquid...
Sulfonolipids (SoLs) are a unique class of sphingolipids featuring sulfonate group compared to other sphingolipids. However, the biological functions and biosynthesis SoLs in human microbiota have been poorly understood. Here, we report discovery isolation from opportunistic pathogen Chryseobacterium gleum DSM16776. We show for first time pro-inflammatory activity with mice primary macrophages. Furthermore, used both vivo heterologous expression vitro biochemical reconstitution characterize...
Toad venom: Bufogargarizins A and B with unprecedented skeletons were discovered from the venom (middle) of Bufo bufo gargarizans (left). The absolute configurations elucidated by spectroscopic data, X-ray crystal diffraction, modified Mosher's method computational analysis. Detailed facts importance to specialist readers are published as "Supporting Information". Such documents peer-reviewed, but not copy-edited or typeset. They made available submitted authors. Please note: publisher is...
Five new C23 steroids (1–5) together with five known bufadienolides (6–10) were isolated from the venom of Bufo bufo gargarizans (ChanSu in Chinese). The structures elucidated by extensive spectroscopic methods combination X-ray diffraction analysis. Among these steroids, only compound 3 showed cytotoxicities against HepG2 and A549 cancer cells, respective IC50 values 26.8 ± 8.3 45.6 2.5 μM. In contrast, (7–10) displayed potent inhibitory activities ranges 0.5–5.5 0.6–6.5 μM, but relatively...
Bufospirostenin A (1) and bufogargarizin C (2), two novel steroids with rearranged A/B rings, were isolated from the toad Bufo bufo gargarizans. Compound 1 represents first spirostanol found in animals. 2 is an unusual bufadienolide a cycloheptatriene B ring. Their structures elucidated by spectroscopic analysis, single crystal X-ray diffraction computational calculations.
New cardenolides with potent cytotoxic and Na<sup>+</sup>,K<sup>+</sup>-ATPase inhibitory activities were isolated from the ornamental milkweed <italic>Asclepias curassavica</italic>.
Abstract Cardiotonic steroids (CTS) are clinically important drugs for the treatment of heart failure owing to their potent inhibition cardiac Na + , K -ATPase (NKA). Bufadienolides constitute one two major classes CTS, but little is known about how they interact with NKA. We report a remarkable stereoselectivity NKA by native 3β-hydroxy bufalin over 3α-isomer, yet replacing group larger polar groups in same configuration enhances inhibitory potency. Binding 13 C-labelled glycosyl...
Background Natural products present in low quantity herb medicines constitute an important source of chemical diversity. However, the isolation sufficient amounts these abundant constituents for structural modification has been a challenge several decades and subsequently halts research on utilization this entities drug discovery development. And, pro-angiogenic therapies are being explored as options to treat cardio-cerebral vascular diseases wound healing recently. The study investigates...
Callisretones A (1) and B (2), two rearranged phloroglucinol-monoterpenoid adducts featuring an unprecedented isopropylcyclopenta[b]benzofuran backbone, together with their postulated biosynthetic precursors (3-9), were isolated from Callistemon rigidus. The previously assigned absolute configurations of viminalins H (7), L (8), N (9) revised unequivocally established by X-ray diffraction data. putative pathway toward callisretones involving the rearrangement terpenoid motif is proposed. In...