A5102000925- Liver Disease Diagnosis and Treatment
- interferon and immune responses
- Pharmacological Effects of Natural Compounds
- Biochemical effects in animals
- Herpesvirus Infections and Treatments
- Autophagy in Disease and Therapy
- Tryptophan and brain disorders
- Sirtuins and Resveratrol in Medicine
- Immune cells in cancer
- Immune Response and Inflammation
- Medicinal Plants and Neuroprotection
- Cancer, Stress, Anesthesia, and Immune Response
- Bee Products Chemical Analysis
- Immune Cell Function and Interaction
- Ferroptosis and cancer prognosis
- Parkinson's Disease Mechanisms and Treatments
- Eicosanoids and Hypertension Pharmacology
- Calcium signaling and nucleotide metabolism
- Diet, Metabolism, and Disease
- Influenza Virus Research Studies
- Stress Responses and Cortisol
- Adipose Tissue and Metabolism
- Tea Polyphenols and Effects
- Aldose Reductase and Taurine
- Pregnancy and preeclampsia studies
Jinan University
2016-2025
Jilin University
2021-2024
Jilin Medical University
2024
Guangzhou University of Chinese Medicine
2024
Shandong University
2024
Chinese Academy of Sciences
2024
Institute of Solid State Physics
2024
Hefei Institutes of Physical Science
2024
Chongqing Jiaotong University
2024
Union Hospital
2022-2024
Abstract During cancer therapy, phagocytic clearance of dead cells plays a vital role in immune homeostasis. The nonapoptotic form cell death, ferroptosis, exhibits extraordinary potential tumor treatment. However, the phagocytosis mechanism that regulates engulfment ferroptotic remains unclear. Here, we establish novel pathway for is different from canonical mechanisms by using diverse ferroptosis models evoked GPX4 dysfunction/deficiency. We identified oxidized phospholipid,...
It is well known that vitamin C could protect against influenza infection, but little about the mechanisms. This study aimed to investigate influence and possible mechanisms of on pneumonia induced by virus in stressed mice. Results showed restraint stress significantly increased mortality severity mice caused A/FM/1/47(H1N1) which was attenuated oral administration (125 250 mg/kg). Moreover, decreased expression susceptibility genes, including mitochondrial antiviral signaling (MAVS)...
Phospholipid peroxidation of polyunsaturated fatty acids at the bis-allylic position drives ferroptosis. Here we identify a novel role for phospholipid in inhibition autophagy. Using vitro and vivo models, report that induced by glutathione peroxidase-4 arachidonate 15-lipoxygenase overexpression leads to overload peroxidized phospholipids culminate Functional lipidomics analysis further demonstrated autophagy was associated with an increase phosphatidylethanolamine (PE) conjugated LC3. We...
Stress has been proven to modulate an individual's immune system through the release of pituitary and adrenal hormones such as catecholamines, growth hormone glucocorticoids. These signal molecules can significantly alter host make it susceptible viral infection. In this study, we investigate whether epigoitrin, a natural alkaloid from Isatis indigotica, provide protection against influenza infection by reducing host's susceptibility virus under stress it's underlying mechanism. To prove it,...
Carnosine (β-alanyl-L-histidine), a naturally occurring dipeptide, has been characterized as putative neurotransmitter and serves reservoir for brain histamine, which could act on histaminergic neurons system to relieve stress-induced damages. However, understanding of the role carnosine in stress-evoked immunocompromise is limited. In this study, results showed that when mice were subjected restraint stress, spleen index number lymphocytes including Natural Killer (NK) cells obviously...
Objective: Non-alcoholic fatty liver disease (NAFLD), previously thought to predominantly affect obese individuals, has also been shown occur in subjects who have a relatively normal body mass index (BMI). Due the BMI, non-obese NAFLD are easily be ignored and eventually lead potential injuries. Methods: A population-based cross-sectional study was conducted on 1608 cases with serum alanine aminotransferase (ALT) levels were divided into an group (BMI ≥ 25 kg/m 2 ) < ). diagnosed by...
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease characterized by oxidative stress that triggers motor neurons loss in the brain and spinal cord. However, mechanisms underlying exact role of ALS-associated neural degeneration are not definitively established. Oxidative stress-generated phospholipid peroxides known to have extensive physiological pathological consequences tissues. Here, we discovered deficiency glutathione peroxidase 4 (GPX4), an essential...
Tamarind shell is rich in flavonoids and exhibits good biological activities. In this study, we aimed to analyze the chemical composition of tamarind extract (TSE), investigate antioxidant capacity TSE vitro vivo. The shells were extracted with 95% ethanol refluxing extraction, constituents determined by ultra-performance chromatography-electrospray tandem mass spectrometry (UPLC-MS/MS). free radical scavenging activity was evaluated using oxygen absorbance (ORAC) method. antioxidative...
The study of the fungal communities skin constitutes a pivotal component microbiome research. Within these communities, genus Malassezia stands out as major constituent, representing 50% to 80% total colonization on healthy individuals. excessive growth or metabolic irregularities this are intimately connected with onset various disorders that intrinsically linked its lipid-dependent nature. Cutaneous lipid metabolism is indispensable for maintaining barrier function and health. possesses...
We demonstrate that caffeine could improve HED-induced hepatic steatosis by promoting lipid metabolism <italic>via</italic> the cAMP/CREB/SIRT3/AMPK/ACC pathway. SIRT3 acts as a molecular bridge connecting and metabolism.
// Chong Jie 1, 2 , Zhuo Luo Huan Chen Min Wang 3 Chang Yan Zhong-Fu Mao Gao-Keng Xiao Hiroshi Kurihara Yi-Fang Li and Rong-Rong He 1 Anti-Stress Health Research Center, College of Pharmacy, Jinan University, Guangzhou 510632, China Institute Traditional Chinese Medicine & Natural Products, Department Hainan General Hospital, 570311, Correspondence to: He, email: rongronghe@jnu.edu.cn Li, liyifang706@jnu.edu.cn Kurihara, Kurihara_hiroshi@163.com Keywords: indirubin; influenza virus; virus...