A5101446154- Herpesvirus Infections and Treatments
- Pharmacological Effects of Natural Compounds
- interferon and immune responses
- Stress Responses and Cortisol
- Pharmacological Effects and Toxicity Studies
- Influenza Virus Research Studies
- Gastrointestinal Bleeding Diagnosis and Treatment
- Endoplasmic Reticulum Stress and Disease
- Advanced Data Compression Techniques
- Natural Compounds in Disease Treatment
- Tryptophan and brain disorders
- Tracheal and airway disorders
- Dermatology and Skin Diseases
- Forensic Entomology and Diptera Studies
- Herbal Medicine Research Studies
- Autopsy Techniques and Outcomes
- Airway Management and Intubation Techniques
- Growth Hormone and Insulin-like Growth Factors
- Microtubule and mitosis dynamics
- Genomics, phytochemicals, and oxidative stress
- Takotsubo Cardiomyopathy and Associated Phenomena
- Human-Animal Interaction Studies
- Mosquito-borne diseases and control
- Flavonoids in Medical Research
- Animal testing and alternatives
Guangxi Medical University
2024
Jinan University
2017-2022
Chongqing University
2018
Huazhong University of Science and Technology
2009-2015
Institute of Forensic Science
2015
University of Maryland, Baltimore
2012
Oxidative DNA damage in bone marrow cells is the main side effect of chemotherapy drugs including cyclophosphamide (CTX). However, not all antioxidants are effective inhibiting oxidative damage. In this study, we report beneficial carnosine (β-alanyl-l-histidine), a special antioxidant with acrolein-sequestering ability, on CTX-induced cell suppression. Our results show that treatment (100 and 200 mg/kg, i.p.) significantly inhibited generation reactive oxygen species (ROS)...
Herpes simplex virus type 1 (HSV-1) is a ubiquitous and widespread human pathogen, which gives rise to range of diseases, including cold sores, corneal blindness, encephalitis. Currently, the use nucleoside analogs, such as acyclovir penciclovir, in treating HSV-1 infection often presents limitation due their side effects low efficacy for drug-resistance strains. Therefore, new anti-herpetic drugs strategies should be urgently developed. Here, we reported that baicalein, naturally derived...
Stress has been proven to modulate an individual's immune system through the release of pituitary and adrenal hormones such as catecholamines, growth hormone glucocorticoids. These signal molecules can significantly alter host make it susceptible viral infection. In this study, we investigate whether epigoitrin, a natural alkaloid from Isatis indigotica, provide protection against influenza infection by reducing host's susceptibility virus under stress it's underlying mechanism. To prove it,...
Chronic stress-evoked depression has been implied to associate with the decline of adult hippocampal neurogenesis. Caffeine known combat depression. Herein, we aim investigate whether protective effect caffeine on is related improving hippocampus neurogenesis and explore mechanisms. Mouse chronic water immersion restraint stress (CWIRS) model, corticosterone (CORT)-established cell a coculture system containing CORT-treated BV-2 cells neural stem (NSCs) were utilized. Results showed that...
// Chong Jie 1, 2 , Zhuo Luo Huan Chen Min Wang 3 Chang Yan Zhong-Fu Mao Gao-Keng Xiao Hiroshi Kurihara Yi-Fang Li and Rong-Rong He 1 Anti-Stress Health Research Center, College of Pharmacy, Jinan University, Guangzhou 510632, China Institute Traditional Chinese Medicine & Natural Products, Department Hainan General Hospital, 570311, Correspondence to: He, email: rongronghe@jnu.edu.cn Li, liyifang706@jnu.edu.cn Kurihara, Kurihara_hiroshi@163.com Keywords: indirubin; influenza virus; virus...
Abstract Although stress has been known to increase the susceptibility of pathogen infection, underlying mechanism remains elusive. In this study, we reported that restraint dramatically enhanced morbidity and mortality mice infected with influenza virus (H1N1) obviously aggravated lung inflammation. Corticosterone (CORT), a main type glucocorticoids in rodents, was secreted plasma stressed mice. We further found hormone significantly boosted replication by restricting mitochondrial...
The pharmacokinetics and mechanisms of elimination recombinant human macrophage-colony stimulating factor (M-CSF) were investigated in rats. Intravenous injections 0.1, 1 or 10 mg/kg M-CSF administered plasma samples measured for by bioassay. Systemic clearance decreased the shape concentration-time curve changed with increasing dose, indicating nonlinear pharmacokinetics. At mg/kg, two half-lives initially observed, but after about 20 hr suddenly declined a steep slope. rapidly declining...
Rationale: Herpes simplex virus type 1 (HSV-1) is a neurotropic that can cause variety of clinical syndromes including mucocutaneous disease and HSV-1 encephalitis (HSE). Here, we characterize the molecular mechanisms underlying susceptibility to under stressful conditions. Methods: Restraint stress corticosterone (CORT, primary hormone) were respectively used establish susceptible model in vivo vitro. Viral titers determined by plaque assay. Western blotting, immunofluorescence,...
This paper addresses the problem of automatically locating boundary between stomach and small intestine (the pylorus) in wireless capsule endoscopy (WCE) video. For efficient image segmentation, color-saliency region detection (CSD) method is developed for obtaining potentially valid frame (VROF). To improve accuracy pylorus, we design Monitor-Judge model. On one hand, color-texture fusion feature visual perception (CTVP) constructed by grey level cooccurrence matrix (GLCM) from maximum...
Owing to environmental and lifestyle changes in modern society, physical mental stress is on the rise among population attempting compensate for changes. Stress, defined as a series of non-specific responses abnormal internal external stimuli, has long been recognized increase susceptibility various diseases, including neurodegenerative diseases (NDs). Herpes simplex virus type 1 (HSV-1), neurotropic herpes virus, establishes latent infections trigeminal ganglia lifetime host. Upon...
Routinely used procedures for chemical fixation often fail to preserve delicate membrane-bounded tubular structures in a variety of cell types. Fixation commonly employed immunocytochemical studies localization structural proteins, such as those found cytoskeletal elements, may also degrade these structures. Here we describe procedure that preserves the elaborate lysosome system stimulated macrophages and allows subsequent immunofluorescence microtubules same cells. Use this methodology...
Wireless capsule endoscopy (WCE) is a developed revolutionary technology with important clinical benefits. But the huge image data brings heavy burden to doctors for locating and diagnosing lesion images. In this paper, novel efficient approach proposed help clinicians detect protruding images in small intestine. First, since there are many possible disturbances such as air bubbles so on WCE video frames, which add difficulty of feature extraction, color-saliency region detection (CSD)...