A5033019247- Multiple Myeloma Research and Treatments
- Renal Transplantation Outcomes and Treatments
- Thermochemical Biomass Conversion Processes
- Organ Transplantation Techniques and Outcomes
- Protein Degradation and Inhibitors
- Heavy metals in environment
- Peptidase Inhibition and Analysis
- Atmospheric chemistry and aerosols
- Air Quality and Health Impacts
- Petroleum Processing and Analysis
- Renal Diseases and Glomerulopathies
- Neuroscience and Neuropharmacology Research
- Air Quality Monitoring and Forecasting
- Natural Compounds in Disease Treatment
- Transplantation: Methods and Outcomes
- Coconut Research and Applications
- Peanut Plant Research Studies
- Cardiac electrophysiology and arrhythmias
- Coal Properties and Utilization
- Dam Engineering and Safety
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Catalytic Processes in Materials Science
- Soil Carbon and Nitrogen Dynamics
- Wastewater Treatment and Nitrogen Removal
- Dyeing and Modifying Textile Fibers
Zhongshan Hospital
2018-2024
Fudan University
2018-2024
Sun Yat-sen University
1998-2024
The First Affiliated Hospital, Sun Yat-sen University
2022-2024
First Hospital of Shijiazhuang
2013-2024
Kunming University of Science and Technology
2020-2022
State Key Laboratory of Medical Neurobiology
2018-2022
Taiyuan University of Technology
2018-2020
Sinopec Research Institute of Petroleum Processing
2020
Energy Foundation
2020
Abstract Background The prognostic value of additional copies chromosome 1q (1q gain/amplification [amp]) in multiple myeloma (MM) remains controversial. In the meantime, kinetics response to MM therapy has long been an area debate. Few studies have pointed out relationship with cytogenetic abnormalities (CAs) MM. Methods authors retrospectively analyzed data 1068 real‐world newly diagnosed patients from a Chinese national medical center. Results Overall, 405 (51.9%) had gain/amp, aggressive...
Summary The tumour microenvironment (TME) plays a critical role in disease progression multiple myeloma (MM). This study aimed to present an atlas of MM‐TME and explore TME‐directed therapeutic strategies. We performed single‐cell RNA sequencing (scRNAseq) samples from different stages. validated the findings by bulk RNAseq, flow cytometry (FCM) vitro vivo functional experiments. delineated compromised TME during progression, characterized enrichment exhausted NK cells CD8 + T reprogramming...
Pure rankinite (C₃S₂) was prepared by calcining a C-S-H gel precursor at temperature of 1300 °C. The carbonation hardening behavior the resulting revealed X-ray diffraction (XRD), Fourier transform-infrared (FT-IR) spectroscopy, thermogravimetry and differential thermal analysis (TG/DTA), scanning electron microscope (SEM) coupled with energy dispersive spectrum (EDS). results indicate that pure can be easily lower temperature. cubic compressive strengths samples reach value 62.5 MPa after...
Potassium chloride co-transporter 2 (KCC2), a major transporter that maintains GABAA receptor inhibition in mature mammalian neurons, is down-regulated the hippocampus during epileptogenesis. Impaired KCC2 function accelerates or facilitates seizure onset. Calpain, with two main subtypes of m- and μ-calpain, Ca2+-dependent cysteine protease mediates nonlysosomal degradation KCC2. Although recent studies have demonstrated calpain inhibitors exert antiepileptic neuroprotective effects animal...
Multiple myeloma (MM) is a highly heterogeneous hematologic tumor. Ubiquitin proteasome pathways (UPP) play vital role in its initiation and development. We used cox regression analysis least absolute shrinkage selector operation (LASSO) to select ubiquitin pathway associated genes (UPPGs) correlated with the overall survival (OS) of MM patients Gene Expression Omnibus (GEO) dataset, we formed this into risk score (UPPRS). The association between clinical outcomes responses triggered by...
Inadequate fertilization may result in water pollution and nutrient leaching, especially paddy fi elds.It is expected that the combination of organic inorganic fertilizers reduces addition to crop yield improvement.In this study, combined with was tested under controlled irrigation conditions.With fertilizer, pH soil could be maintained a rather neutral environment, matter concentration increaseespecially regime.Hydrolyzed nitrogen noticed fertilized plots an increasing trend compared...
Integration technology of residue hydrotreating (RHT) and delayed coking (DC) was first proven to be an effective strategy process high-sulfur oil while reducing the coke yield simultaneously controlling sulfur content coke. Then, evolution species in integration investigated by XPS, online TG-MS analysis, atmospheric pressure photoionization FT-ICR MS. Finally, essential effects RHT on were evaluated. The optimized conversion refractory thiophenic sulfurs into sulfidic as indicated...
To improve the early detection rate of multiple myeloma (MM), M-protein screening system has been performed in hospital population at Zhongshan Hospital Fudan University since 2014, with electrophoretic-based monoclonal immunoglobulin (M-protein) integrated into blood biochemistry panel. This study updated 7-year follow-up findings MM patients diagnosed by screening-driven and symptom-driven approaches.
Multiple myeloma (MM) patients with chromosome 1q gain (1q+) are clinically and biologically heterogeneous. The underlying molecular mechanisms still under investigation, while the identification of targets for effective therapy this subgroup MM is urgently needed. We aimed to investigate clinical significance regulatory insulin-like growth factor 2 messenger RNA (mRNA) binding protein 1 (IGF2BP1), a N6-methyladenosine (m6A) reader, in 1q+. found that 1q+ exhibit significantly higher level...
Abstract Objective The purpose of this study is to compare radiological and clinical outcomes between alternate levels (C4 C6) all mini-plate fixation in C3-6 unilateral open-door laminoplasty. Methods Ninety-six patients who underwent laminoplasty with (54 group A) or (42 B) September 2014 2019 were reviewed study. Radiologic assessed. Clinical results included Visual Analogue Scale (VAS) axial neck pain Japanese Orthopedic Association (JOA) score. Radiographic cervical range motion (ROM),...