A5101900381- Platelet Disorders and Treatments
- Blood groups and transfusion
- Chronic Lymphocytic Leukemia Research
- T-cell and B-cell Immunology
- Autoimmune Bullous Skin Diseases
- Cell Adhesion Molecules Research
- Liver Disease Diagnosis and Treatment
- Adipose Tissue and Metabolism
- Exercise and Physiological Responses
- Immune Cell Function and Interaction
- Cancer Genomics and Diagnostics
- Lymphoma Diagnosis and Treatment
- Multiple Myeloma Research and Treatments
- Cardiac Ischemia and Reperfusion
- Immune cells in cancer
- Blood properties and coagulation
- Immunodeficiency and Autoimmune Disorders
- Muscle metabolism and nutrition
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Genomics and Rare Diseases
- Signaling Pathways in Disease
- Orthopedic Infections and Treatments
- Lipid metabolism and disorders
- Genetic factors in colorectal cancer
Sun Yat-sen University
2016-2025
The First Affiliated Hospital, Sun Yat-sen University
2016-2025
Zhongshan Hospital
2016-2025
Fudan University
2016-2025
Taizhou People's Hospital
2024
Nantong University
2024
Ningbo University
2023
Chinese Medical Association
2023
Chengdu University
2017-2023
First Affiliated Hospital of Wenzhou Medical University
2018-2022
Primary immune thrombocytopenia (ITP) is an autoimmune heterogeneous disorder that characterized by decreased platelet count. Regulatory T (Treg) cells and helper type 17 (Th17) are two subtypes of CD4(+) (Th) cells. They play opposite roles in tolerance diseases, while they share a common differentiation pathway. The imbalance Treg/Th17 has been demonstrated several diseases. In this study, we aimed to investigate the ratio number Treg Th17 ITP patients evaluate clinical implications...
Background The prognosis of chronic lymphocytic leukemia (CLL) has been improved dramatically, but there are limited studies focusing on CLL disease burden a global scale. We aimed to evaluate the accurate assessment that may provide more detailed epidemiological information for rational policies. Methods main source data was Global Burden Disease (GBD) study 2019. Incident cases, death disability-adjusted life years (DALYs), and their corresponding age-standardized rates (ASRs) from 1990...
// Xiao-Li Huang 2, * , Yang He 1, Li-Li Ji 3, Kai-Yu Wang 2 Yi-Li 4 De-Fang Chen Yi Geng 1 Ping OuYang and Wei-Min Lai Department of Basic Veterinary, College Veterinary Medicine, Key Laboratory Animal Disease Human Health Sichuan Province, Agricultural University, Wenjiang, Sichuan, P.R. China Aquaculture, Science & Technology, P. R. 3 Meat Processing Chengdu Chengdu, Tiantian Biotechnology Application Ltd, These authors have contributed equally to this work Correspondence to: Wang,...
Sour meat is a highly appreciated traditional fermented product, mainly from the Guizhou, Yunnan, and Hunan provinces. The flavor profiles of sour goose pork were evaluated using gas chromatography-ion mobility spectrometry (GC-IMS) combined with an electronic nose (E-nose) tongue (E-tongue). A total 94 volatile compounds characterized in both GC-IMS. data-mining protocol based on univariate multivariate analyses revealed that source raw plays crucial role formation during fermentation...
Summary Primary immune thrombocytopenia (ITP) is an autoimmune disorder characterized by isolated thrombocytopenia. This bibliometric analysis was applied to identify the characteristics of global scientific output, hotspots, and frontiers ITP over past 10 years. We retrieved publications from 2011 2021 Web Science Core Collection (WoSCC). Bibliometrix package, VOSviewer, Citespace were used analyse visualize trend, distribution, hotspots research on ITP. Altogether, there 2084 papers,...
Oxidative stress is a major contributor to the onset and development of myocardial ischemia reperfusion injury (MIRI). Sappanone A (SA), homoisoflavanone extracted from heartwood Caesalpinia sappan L., has been demonstrated possess powerful antioxidant activity. Therefore, this study aimed determine protective effect SA on MIRI investigate its underlying mechanism.The rat hearts were isolated underwent 30-min ischemia, followed by 120-min establish model, using Langendorff method. was...
Background The first‐line therapy is effective for the treatment of primary immune thrombocytopenia (ITP); however, maintaining long‐term responses remains challenging. Low‐dose decitabine (DAC) has been adopted to treat refractory ITP, while its role in macrophage polarization not fully understood. We aimed investigate mechanistic DAC M2 and evaluated therapeutic effect ITP. Methods monocytes were identified by flow cytometry from peripheral blood mononuclear cells healthy controls (HCs)...
Primary immune thrombocytopenia (ITP) is a heterogeneous autoimmune disease, characterized by decreased platelet count and increased risk of hemorrhage, in which macrophages play an important role the pathogenesis. This study aims to explore effects YC-4-3, patented chemical synthesis benzothiazepinone compounds (BTZs), novel GSK-3β inhibitor (GSK-3βi), on ITP. The expressions monocytes are tested. GSK-3βi (YC-4-3) ITP patients examined validated passive active murine models. Signal pathway...
Although impaired myeloid-derived suppressor cells (MDSCs) recently have been studied in immune thrombocytopenia (ITP), another cell population signified as M2 macrophages has not investigated properly ITP patients. In the present study, we intended to determine features of circulating M2-like macrophages, examine its relationship with MDSCs, and explore their prognostic values ITP. Peripheral blood mononuclear from healthy controls primary patients were isolated test MDSCs. The macrophage...
Aging is known to be associated with alterations of both oxidative capacity and antioxidant status in skeletal muscle. In the present investigation we compared activity enzymes involved metabolic functions defense young adult (5 months old) senescent (27.5 Fischer 344 rats. addition, studied effects chronic exercise training on these Old sedentary rats had significantly lower glutathione peroxidase (GPX) (––22%, p < 0.05) deep portion vastus lateralis muscle (DVL) than rats, but after a...
Background . Regulatory B cells (Breg) are a distinct cell subset with immunoregulatory properties. Pivotal to Breg function is interleukin-10. This study was investigate the role of IL-10-producing (B10) and its association Treg Th17 subsets in immune thrombocytopenia (ITP) patients. Methods Peripheral blood mononuclear from ITP patients controls were stimulated PMA, ionomycin, Brefeldin A. The frequencies CD19 + IL-10 cells, CD3 CD4 IL-17 CD25 hi Foxp3 analyzed by flow cytometry. mRNA...
Background: Primary immune thrombocytopenia (ITP) is an autoimmune-mediated disorder characterized by a decreased platelet count. Systemic lupus erythematosus (SLE) also autoimmune disease in which common hematologic manifestation. Interleukin (IL)-1 family cytokines are major proinflammatory and immunoregulatory mediators. This study aimed to investigate the role of IL-1 patients with ITP SLE potential pathophysiologic mechanism differentiate SLE-associated (SLE-TP) from ITP. Methods:...
Th17/Treg balance skews towards Th17 in ITP patient. IRF4 has been highlighted for its close relationship to the immunosuppressive function of Treg cells and IL-17 synthesis CD4+ T cells. This study was aimed at examining effects patients with ITP.Treg Teff were isolated from PBMCs newly diagnosed patients. The percentages CD4+CD25hiFoxp3+Treg CD3+CD4+IL-17+Th17 detected by flow cytometry. After being cultured, supernatants Tregs collected IL-10 concentration test. levels measured. Teffs...
The prognostic value of 1q21 Gain/Amplification (1q21 Gain/Amp) in multiple myeloma (MM) has always been controversial. A total 419 newly diagnosed MM patients were included this retrospective study. positive rate Gain/Amp was 48.6%. with characterized as being more advanced clinical stages and likely to be accompanied by del(13q14), t(4;14) or complex karyotypes (CKs) well severe anemia worse renal function. In these patients, the percentage complete remission (CR) very good partial...
Abstract Myocardial ischemia reperfusion injury (MIRI) is a complex pathophysiological process involved with the activation of oxidative stress, inflammation and apoptosis. Sappanone A (SA), homoisoflavanone isolated from heartwood Caesalpinia sappan L., could exhibit antioxidant, anti-inflammatory anti-apoptotic activities. Therefore, we assumed that SA has potential use for preventing against MIRI. The present study aimed to investigate effect treatment on MIRI its mechanism....
Aquatic products are one of the world's essential protein sources whose quality and safety threatened by bacterial diseases. This study investigated possible effects infection on main edible part, muscle, in case crayfish infected with Citrobacter freundii. The histopathological analysis confirmed that was sensitive to C. freundii muscle target organs. transcriptome results showed impaired intercellular junctions, downregulation actin expression, inhibition metabolic pathways. Furthermore,...
To investigate the relationships between inflammatory parameters, including neutrophil‐to‐lymphocyte ratio (NLR), platelet‐to‐lymphocyte (PLR), monocyte-to-lymphocyte (MLR) and systemic immune-inflammation index (SII), quantitative flow (QFR) in stable coronary artery disease (CAD) patients ( n = 450) enrolled this cross-sectional study. Logistic regression was performed to evaluate associations of NLR, PLR, MLR, SII evaluated as continuous binary variables with QFR ≤0.80. When treated...