A5069367266- Multiple Myeloma Research and Treatments
- Chronic Lymphocytic Leukemia Research
- Lymphoma Diagnosis and Treatment
- Protein Degradation and Inhibitors
- Immune Cell Function and Interaction
- Immune cells in cancer
- Cancer, Lipids, and Metabolism
- HER2/EGFR in Cancer Research
- Testicular diseases and treatments
- Monoclonal and Polyclonal Antibodies Research
- Immunotherapy and Immune Responses
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Ubiquitin and proteasome pathways
- Chemokine receptors and signaling
- Phagocytosis and Immune Regulation
- Peptidase Inhibition and Analysis
- Inflammatory Biomarkers in Disease Prognosis
- CAR-T cell therapy research
The First Affiliated Hospital, Sun Yat-sen University
2020-2023
Zhongshan Hospital
2020-2023
Fudan University
2020-2023
Sun Yat-sen University
2020-2023
Summary The tumour microenvironment (TME) plays a critical role in disease progression multiple myeloma (MM). This study aimed to present an atlas of MM‐TME and explore TME‐directed therapeutic strategies. We performed single‐cell RNA sequencing (scRNAseq) samples from different stages. validated the findings by bulk RNAseq, flow cytometry (FCM) vitro vivo functional experiments. delineated compromised TME during progression, characterized enrichment exhausted NK cells CD8 + T reprogramming...
The prognostic value of 1q21 Gain/Amplification (1q21 Gain/Amp) in multiple myeloma (MM) has always been controversial. A total 419 newly diagnosed MM patients were included this retrospective study. positive rate Gain/Amp was 48.6%. with characterized as being more advanced clinical stages and likely to be accompanied by del(13q14), t(4;14) or complex karyotypes (CKs) well severe anemia worse renal function. In these patients, the percentage complete remission (CR) very good partial...
Multiple myeloma (MM) is a highly heterogeneous hematologic tumor. Ubiquitin proteasome pathways (UPP) play vital role in its initiation and development. We used cox regression analysis least absolute shrinkage selector operation (LASSO) to select ubiquitin pathway associated genes (UPPGs) correlated with the overall survival (OS) of MM patients Gene Expression Omnibus (GEO) dataset, we formed this into risk score (UPPRS). The association between clinical outcomes responses triggered by...
Abstract Background Obesity is a risk factor for multiple myeloma (MM). However, we still lack knowledge on the clinical course of obese MM patients in broad view. Methods Here, reviewed 568 recorded Multiple Myeloma Research Foundation (MMRF) coMMpass dataset. Patients were divided into normal and groups according body mass index (BMI) at diagnosis, then baseline characteristics, cytogenetic abnormalities, treatment variability, survival outcomes evaluated cohort. Results We found no...
Objectives The clinical outcomes of multiple myeloma (MM) patients are highly variable in the real-world setting. Some MM may have endings that do not abide by book. We aim to describe features with extreme survivals practice.
慢性淋巴细胞白血病(chronic lymphocytic leukemia, CLL)是西方国家最常见的成人白血病, 在我国的发病率也日益增加。近年来针对CLL的新药层出不穷, 微小残留病灶(minimal residual disease, MRD)监测逐渐成为评估疗效的重要手段。本文总结了目前常用的MRD检测方法, 包括流式细胞学和基于PCR法的分子学检测, 并介绍了其在初治CLL疗效评价、预后评估和在移植后CLL复发预警方面的应用进展。