A5100626238- Advanced Neuroimaging Techniques and Applications
- MRI in cancer diagnosis
- Advanced MRI Techniques and Applications
- Functional Brain Connectivity Studies
- Radiomics and Machine Learning in Medical Imaging
- Lanthanide and Transition Metal Complexes
- Endometrial and Cervical Cancer Treatments
- Neonatal and fetal brain pathology
- Ovarian cancer diagnosis and treatment
- Cancer Immunotherapy and Biomarkers
- Ferroptosis and cancer prognosis
- Fetal and Pediatric Neurological Disorders
- EEG and Brain-Computer Interfaces
- Aquaculture disease management and microbiota
- Bone and Joint Diseases
- Intracerebral and Subarachnoid Hemorrhage Research
- Animal Virus Infections Studies
- Neural and Behavioral Psychology Studies
- Acute Ischemic Stroke Management
- Liver Disease Diagnosis and Treatment
- Heart Rate Variability and Autonomic Control
- RNA modifications and cancer
- Medical Imaging and Analysis
- Pancreatic function and diabetes
- Lung Cancer Diagnosis and Treatment
Beijing Friendship Hospital
2024-2025
Capital Medical University
2024-2025
Second Affiliated Hospital of Harbin Medical University
2022-2024
Jilin University
2010-2024
Harbin Medical University
2022-2024
Shandong University
2024
General Electric (Spain)
2021-2024
China Medical University
2018-2024
Liaoning Cancer Hospital & Institute
2018-2024
Chinese Academy of Sciences
2024
Background Cryoablation is a minimally invasive option for patients with medically inoperable non-small cell lung cancer (NSCLC) and can trigger abscopal immune-regulatory effects. However, it remains unclear how cryoablation affects the host-level immune response in NSCLC. In this study, we investigated local systemic immunological effects of potential combining programmed death protein 1 (PD-1) blockade to boost immunotherapy efficacy Methods We first induced by early-stage Subsequently,...
Rationale and ObjectivesThis study employed tract-based spatial statistics (TBSS) to investigate abnormalities in the white matter microstructure among children with autism spectrum disorder (ASD). Additionally, an eXtreme Gradient Boosting (XGBoost) model was developed effectively classify individuals ASD typical developing (TDC).Methods MaterialsMulti-shell diffusion weighted images were acquired from 62 44 TDC. Using Pydesigner procedure, tensor (DT), kurtosis (DK), tract integrity (WMTI)...
// Xiao-Li Huang 2, * , Yang He 1, Li-Li Ji 3, Kai-Yu Wang 2 Yi-Li 4 De-Fang Chen Yi Geng 1 Ping OuYang and Wei-Min Lai Department of Basic Veterinary, College Veterinary Medicine, Key Laboratory Animal Disease Human Health Sichuan Province, Agricultural University, Wenjiang, Sichuan, P.R. China Aquaculture, Science & Technology, P. R. 3 Meat Processing Chengdu Chengdu, Tiantian Biotechnology Application Ltd, These authors have contributed equally to this work Correspondence to: Wang,...
Background Endometrial carcinoma (EC) risk stratification is generally based on histological assessment. It would be beneficial to perform noninvasively by MRI. Purpose To investigate the application of amide proton transfer‐weighted imaging (APTWI), monoexponential, biexponential, and stretched exponential intravoxel incoherent motion (IVIM), diffusion kurtosis (DKI) for evaluation in early‐stage EC. Study Type Prospective. Population Eighty patients with EC (47 classified as low risk, 20...
In recent years, a modified percutaneous vertebroplasty procedure, known as Vesselplasty, has demonstrated favorable clinical outcomes in the treatment of osteoporotic vertebral compression fractures (OVCFs). However, there have been no reports on application Vesselplasty for Genant grade 3 OVCFs. This study aims to evaluate efficacy and treating OVCFs, thereby providing evidence-based guidance decision-making. A retrospective was conducted 41 patients with OVCFs who underwent traditional...
This study aimed to evaluate the impact of direct total cavopulmonary connection (dTCPC) procedure on gut microbiome and metabolome. It also sought elucidate features microbiota community metabolic profiles in Fontan circulation. We randomly recruited 45 participants above 14 years old undergoing by typical extracardiac conduit (TCPC group, n = 15), (dTCPC 16) healthy control (control 14) our institution between May 2023 October 2023. 16S rRNA amplicon sequencing untargeted metabolites...
Previous studies on brain functional connectivity have revealed the neural physiopathology in patients with pontine stroke (PS). However, those focused only static features of intrinsic fluctuations, rather than time-varying effects throughout entire scan. In present study, we sought to explore underlying mechanism PS using dynamic network (dFNC) method. Resting-state magnetic resonance imaging (fMRI) data were collected from 58 and 52 healthy controls (HC). Independent component analysis...
Aim: Exenatide is a glucagon-like peptide 1receptor agonist, having both glycemic and weight loss benefits. Given that previous pharmacogenetic studies reported inconsistent evidence of association between variants in the drug target gene GLP1R response to exenatide, we set out examine two common coding Chinese population. Materials & methods: Here, recruited 285 overweight Type 2 diabetes patients from China investigated missense using multivariate linear model with adjustment for baseline...
Background Amide proton transfer‐weighted imaging (APTWI) and intravoxel incoherent motion (IVIM) are valuable MRI techniques applied to cancer. Purpose To compare APTWI IVIM in the diagnosis of benign malignant breast lesions evaluate correlations between different parameters (MTRasym [3.5 ppm], D, D*, f) prognostic factors for Study Type Retrospective. Population In all, 123 were studied before treatment, including 58 65 lesions. Field Strength/Sequence Conventional (T 1 WI, T 2...
Abstract Cognitive dysfunction in patients with infratentorial stroke has been paid little attention. Brainstem may disrupt network connectivity across the whole brain and affect multidomain cognition, but details of this process remain unclear. The study aimed to investigate effects stroke‐induced pontine injury on whole‐brain cognitive function. We included 47 56 healthy comparisons (HC), who underwent tests functional magnetic resonance imaging (fMRI). Seven meaningful networks were...
Conventional magnetic resonance imaging (MRI) features have difficulty distinguishing glioma true tumor recurrence (TuR) from treatment-related effects (TrE). We aimed to develop a machine-learning model based on multimodality MRI radiomics help improve the efficiency of identifying TuR. A total 131 patients were enrolled and randomly divided into training set (n = 91) test 40). Radiomic extracted postoperative enhancement (PoE) region edema (ED) four routine sequences. After analyses...
Kaposi's sarcoma-associated herpesvirus (KSHV) is associated with sarcoma and primary effusion lymphoma (PEL). The KSHV replication transcription activator (RTA) latency-associated nuclear antigen (LANA) play key roles in activating lytic maintaining latency, respectively. Phosphorodiamidate morpholino oligomers (PMO) are similar to short single-stranded DNA oligomers, but possess a modified backbone that confers highly specific binding resistance nucleases. In this study, RTA LANA mRNA PEL...
This study aims to evaluate and compare the diagnostic value of DKI APT in prostate cancer (PCa), their correlation with Gleason Score (GS).DKI imaging 49 patients PCa 51 benign prostatic hyperplasia (BPH) were collected analyzed, respectively. According GS, divided into high-risk, intermediate-risk low-risk groups. The mean kurtosis (MK), diffusion (MD) magnetization transfer ratio asymmetry (MTRasym, 3.5 ppm) values among PCa, BPH, different GS groups compared analyzed accuracy each...
Recent neuroimaging studies have shown the possibility of cognitive impairment after pontine stroke. In this study, we aimed to use voxel-mirrored homotopic connectivity (VMHC) investigate changes in function chronic Functional MRI (fMRI) and behavioral assessments were obtained from 56 patients with ischemic stroke [28 left-sided (LP) 28 right-sided (RP)] 35 matched healthy controls (HC). The one-way ANOVA test was performed for three groups VMHC analysis. Results showed that there...
The purpose of the study was to investigate abnormality both static spontaneous brain activity and dynamic temporal variances following a pontine infarction.Forty-six patients with chronic left infarction (LPI), thirty-two right (RPI), fifty healthy controls (HCs) were recruited for study. amplitude low-frequency fluctuations (sALFF), regional homogeneity (sReHo), ALFF (dALFF), ReHo (dReHo) employed detect alterations in induced by an infarction. Rey Auditory Verbal Learning Test Flanker...
Zijun Liu, Baohong Wen, Ziyu Wang, Kaiyu Lizhi Xie, Yimeng Kang, Qiuying Tao, Weijian Yong Zhang, Jingliang Cheng, Yan Zhang
Introduction Sensorineural hearing loss (SNHL) can arise from a diverse range of congenital and acquired factors. Detecting it early is pivotal for nurturing speech, language, cognitive development in children with SNHL. In our study, we utilized synthetic magnetic resonance imaging (SyMRI) to assess alterations both gray white matter within the brains affected by Methods The study encompassed diagnosed SNHL control group normal {1.5-month-olds ( n = 52) 3-month-olds 78)}. Participants were...
The S2 domain of the severe acute respiratory syndrome coronavirus (SARS-CoV) spike (S) protein is responsible for fusion between virus and target cell membranes, expected to be immungenic. In this study, we investigated immune responses against subunit in BALB/c mice, which were vaccinated either with plasmid DNA encoding (residues 681–1120), recombinant fragment 681–980) incomplete Freund's adjuvant, or inactivated SARS-CoV. increased number specific cytotoxic cells (CTLs) high titer...