A5100381003- Effects of Radiation Exposure
- Advanced Neuroimaging Techniques and Applications
- Radiation Therapy and Dosimetry
- Advanced MRI Techniques and Applications
- Spaceflight effects on biology
- Radiomics and Machine Learning in Medical Imaging
- Monoclonal and Polyclonal Antibodies Research
- Neuroblastoma Research and Treatments
- Herpesvirus Infections and Treatments
- Glioma Diagnosis and Treatment
- Cerebrovascular and Carotid Artery Diseases
- Functional Brain Connectivity Studies
- Telomeres, Telomerase, and Senescence
- Toxin Mechanisms and Immunotoxins
- Foreign Body Medical Cases
- MRI in cancer diagnosis
- Acupuncture Treatment Research Studies
- Folate and B Vitamins Research
- Nutrition and Health in Aging
- Microwave Imaging and Scattering Analysis
- Kruppel-like factors research
- Hip and Femur Fractures
- Optical Imaging and Spectroscopy Techniques
- Traditional Chinese Medicine Analysis
- Cancer therapeutics and mechanisms
Hebei Medical University
2023-2024
Fourth Hospital of Hebei Medical University
2023-2024
Wannan Medical College
2024
First Affiliated Hospital of Wannan Medical College
2024
Hospital of Hebei Province
2019-2023
Chongqing Medical University
2023
Hung Vuong Hospital
2023
Fujian Medical University
2023
Tianjin Medical University
2022
Kunming Medical University
2022
Summary The selective depletion of senescent cells ( SC s) by small molecules, termed senolytic agents, is a promising therapeutic approach for treating age‐related diseases and chemotherapy‐ radiotherapy‐induced side effects. Piperlongumine PL ) was recently identified as novel agent. However, its mechanism action molecular targets in s unknown thus investigated. Specifically, we used ‐based chemical probe to pull‐down ‐binding proteins from live then mass spectrometry‐based proteomic...
Space flight poses certain health risks to astronauts, including exposure space radiation, with protons accounting for more than 80% of deep-space radiation. Proton radiation is also now being used increasing frequency in the clinical setting treat cancer. For these reasons, there an urgent need better understand biological effects proton on body. Such improved understanding could lead accurate assessment potential as well development strategies prevent and mitigate its adverse effects....
Glioblastoma (GBM) is the most aggressive type of cancer. Its current first-line postsurgery regimens are radiotherapy and temozolomide (TMZ) chemotherapy, both which DNA damage-inducing therapies but show very limited efficacy a high risk resistance. There an urgent need to develop novel agents sensitize GBM DNA-damaging treatments. Here it found that triterpene compound stellettin B (STELB) greatly enhances sensitivity ionizing radiation TMZ in vitro vivo. Mechanistically, STELB inhibits...
Recent neuroimaging studies have shown the possibility of cognitive impairment after pontine stroke. In this study, we aimed to use voxel-mirrored homotopic connectivity (VMHC) investigate changes in function chronic Functional MRI (fMRI) and behavioral assessments were obtained from 56 patients with ischemic stroke [28 left-sided (LP) 28 right-sided (RP)] 35 matched healthy controls (HC). The one-way ANOVA test was performed for three groups VMHC analysis. Results showed that there...
Abstract Background To explore the association between liver metabolism-related indicators in maternal serum and neonatal hyperbilirubinemia (NHB), further investigate predictive value of these NHB-related amino acid metabolism disorders. Methods 51 NHB 182 No-NHB newborns their mothers who treated Fourth Hospital Shijiazhuang from 2018 to 2022 were participated study. The differences clinical data compared by Mann-Whitney U test Chi-square test. Multivariate logistic regression was used...
One of the major health risks to astronauts is radiation on long-duration space missions. Space from sun and galactic cosmic rays consists primarily 85% protons, 14% helium nuclei 1% high-energy high-charge (HZE) particles, such as oxygen (16O), carbon, silicon, iron ions. HZE particles exhibit dense linear tracks ionization associated with clustered DNA damage often high relative biological effectiveness (RBE). Therefore, new knowledge particle exposures must be obtained. In present study,...
During deep space missions, astronauts will be exposed to low doses of charged particle irradiation. The long-term health effects these exposures are largely unknown. We previously showed that oxygen ion (16O) irradiation induced acute damage the hematopoietic system, including progenitor and stem cells in a mouse model. However, chronic dose 16O remain undefined. In current study, we investigated on system. Male C57BL/6J mice were 0.05 Gy, 0.1 0.25 Gy 1.0 whole body (600 MeV/n) bone marrow...
Antibodies have been shown to hinder the movement of herpes simplex virus virions in cervicovaginal mucus, as well other viruses mucus secretions. However, it has not possible directly observe mechanisms underlying this phenomenon, so nature virion–antibody–mucin interactions remain poorly understood. In work, we analyzed thousands virion traces from single particle tracking experiments explicate how antibodies must cooperate immobilize for relatively long time periods. First, using a...
Abnormal cerebral brain flow (CBF) and resting-state functional connectivity (rs-FC) are sensitive biomarkers of disease progression prognosis. This study inves-tigated neural underpinnings motor cognitive recovery by longitudinally studying the changes CBF FC in pontine infarction (PI). Twenty patients un-derwent three-dimensional pseudo-continuous arterial spin labeling (3D-pcASL), magnetic resonance imaging (rs-fMRI) scans, as well be-havioral assessments at 1 week, month, 3 months, 6...
Stroke is a major cause of vascular cognitive dysfunction, such as memory impairment. We aimed to explore the neural substrates underlying verbal impairment in subcortical stroke patients by methods voxel-wise cerebral blood flow (CBF) and functional covariance network (FCN). Sixty with chronic 60 normal controls (NCs) were recruited into this study. used three-dimensional pseudo-continuous arterial spin-labeling imaging measure alterations CBF FCNs. mapped overall manner compared...
The tumour necrosis factor-α (TNF-α) gene plays an important role in the host immune response, which will influence development and clearance of cancer. Polymorphism TNF-α promoter region is considered to its transcription be a risk factor for tumorigenesis. In current study, we evaluated polymorphisms susceptibility cervical intraepithelial neoplasia (CIN) cancer (CC).A total 2732 subjects, including 1173 healthy controls, 579 patients with CIN 980 CC Chinese Han population, were selected...
Osteosarcoma, a rare malignant tumor, has poor prognosis. This study aimed to find the best prognostic model for osteosarcoma. There were 2912 patients included from SEER database and 225 Hebei Province. Patients (2008-2015) in development dataset. (2004-2007) Province cohort external test datasets. The Cox three tree-based machine learning algorithms (survival tree [ST], random survival forest [RSF] gradient boosting [GBM]) used develop models by 10-fold cross-validation with 200...
Exposure to proton irradiation during missions in deep space can lead bone marrow injury. The acute effects of on hematopoietic stem and progenitor cells remain undefined thus were investigated.We exposed male C57BL/6 mice 0.5 1.0 Gy total body (proton-TBI, 150 MeV) examined changes peripheral blood (BM) progenitors LSK 2 weeks after exposure.1.0 proton-TBI significantly reduced the numbers compared unirradiated animals, while cell counts comparable between mice. frequencies CMPs BM...
Classical Philadelphia-negative myeloproliferative neoplasm (MPN) includes Essential Thrombocythemia (ET), Polycythemia Vera (PV) and Primary Myelofibrosis (PMF). The JAK2V617F mutation is part of the major criteria for diagnosis MPN. WT1 reported to be highly overexpressed in most hematological malignancy. Our aim was explore combination value allele burden expression distinguishing subtype MPN patients.Allele specific real-time quantitative fluorescence PCR (AS-qPCR) conducted detect...
Neurological deficits after stroke are closely related to white matter microstructure damage. However, secondary changes in pontine infarction (PI) the whole brain remain unclear. This study aimed investigate correlation of diffusion kurtosis imaging (DKI)-derived and parameters abnormal tracts with behavioral function patients chronic PI. Overall, 60 unilateral PI (33 left 27 right PI) 30 normal subjects were recruited underwent DKI scans. Diffusion derived from tensor (DTI) obtained....
Foreign bodies in the airways can cause significant morbidity and mortality. If emergency personnel are unable to clear an airway obstruction frequently results cardiac arrest.
Objective To explore the impact and value of 11C-MET PET/CT for high-grade glioma in making conformal radiotherapeutic planning compared with MRI. Methods From October 2011 to September 2013, MRI were performed 25 initial cases 9 recurrent cases. All 34 (19 males, 15 females) classified into group (n=17), surgery (n=8) (n=9). GTV was outlined using images combined T1 weighted images. Results 11C-MET optimized radiotherapy targets 22 cases, including 7 8 consistent volume...
Objective To investgate the value of various parameters obtained from monoexponential, biexponential, and stretched exponential diffusion-weighted imaging models in differential diagnosis breast lesions. Methods A retrospective study performed 54 patients with pathologically confirmed malignant tumors(n=30), benign lesions(n=34) normal fibroglandular tissues (n=30). All underwent T1WI, T2WI, dynamic enhancement diffusion weighted MRI multi-b values at a 3.0 T magnetic resonance unit....
Abstract Background The indirect reduction is one kind of micro-invasive technology. most important mechanism traction.The purpose this study was to independently develop a traction device on lower limb fracture and explore the clinical effect treatment tibial adopting device. Methods A retrospective conducted 21patients with adopted assist during operation from August 2019 June 2022. cases included 10 plateau fractures, 6 shaft fractures 5 distal tibia (pilon )fractures. 3 were...
Supplementary Figure from Vitamin D Receptor Activation Attenuates Hippo Pathway Effectors and Cell Survival in Metastatic Neuroblastoma
Supplementary Figure from Vitamin D Receptor Activation Attenuates Hippo Pathway Effectors and Cell Survival in Metastatic Neuroblastoma